Gene Symbol: lrp5
Description: low density lipoprotein receptor-related protein 5
Alias: LRP6, low-density lipoprotein receptor-related protein 5
Lu H, Ma J, Yang Y, Shi W, Luo L. EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev Cell. 2013;24:543-53 pubmed publisher
..Dkk2) interaction, which prevents Kremen1-Dkk2-mediated removal of Lipoprotein-receptor-related protein 6 (Lrp6) from the cell surface...
McGraw H, Culbertson M, Nechiporuk A. Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish. Development. 2014;141:3212-21 pubmed publisher
..Previous studies have shown that Kremen1 inhibits Wnt signaling by facilitating internalization of the Kremen1-Dkk-Lrp5/6 complex...
Reading B, Hiramatsu N, Schilling J, Molloy K, Glassbrook N, Mizuta H, et al
. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. J Lipid Res. 2014;55:2287-95 pubmed publisher
..The presence of lrp13 orthologs in mammals suggests that this lipoprotein receptor is widely distributed among vertebrates, where it may generally play a role in lipoprotein metabolism. ..
Willems B, Tao S, Yu T, Huysseune A, Witten P, Winkler C. The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish. PLoS ONE. 2015;10:e0131768 pubmed publisher
..Here we show that the frizzled co-receptor low-density-lipoprotein (LDL) receptor-related protein 5 (Lrp5) plays a crucial role in CNCC migration and morphogenesis of the cranial skeleton...
Dixon R, Eperon I, Hall L, Samani N. A genome-wide survey demonstrates widespread non-linear mRNA in expressed sequences from multiple species. Nucleic Acids Res. 2005;33:5904-13 pubmed
..These findings imply that RREO affects a significant subset of genes within a genome and suggests that non-linear information encoded within the genomes of complex organisms could contribute to phenotypic variation. ..
Chen M, Philipp M, Wang J, Premont R, Garrison T, Caron M, et al
. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J Biol Chem. 2009;284:35040-8 pubmed publisher
..Subsequently, phosphorylation of serine/threonine residues within five repeating signature PPPSP motifs on LRP6 is responsible for LRP6 activation...
Cui Y, Lv S, Liu J, Nie S, Chen J, Dong Q, et al
. Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Hum Exp Toxicol. 2017;36:207-217 pubmed publisher
..These findings provided evidence that PFOS chronic exposure adversely impacts lipid metabolism in both F0 and F1 and demonstrated the validity of using zebrafish as an alternative model for PFOS chronic toxicity screening. ..
Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, et al
. New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss. Hum Mutat. 2017;38:1421-1431 pubmed publisher
..Whole-exome sequencing (WES) identified lipoprotein receptor-related protein 5 (LRP5), a member of the low-density lipoprotein receptor family, as the causative gene in this family...