Gene Symbol: lrp2a
Description: low density lipoprotein receptor-related protein 2a
Alias: im:680590, lrp2, low-density lipoprotein receptor-related protein 2, gp330b, low density lipoprotein-related protein 2, megalin
Anzenberger U, Bit Avragim N, Rohr S, Rudolph F, Dehmel B, Willnow T, et al
. Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. J Cell Sci. 2006;119:2127-37 pubmed
b>Megalin/LRP2 is an endocytic receptor in the proximal tubules of the mammalian kidney that plays a central role in the clearance of metabolites from the glomerular filtrate...
Kur E, Christa A, Veth K, Gajera C, Andrade Navarro M, Zhang J, et al
. Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Dev Dyn. 2011;240:1567-77 pubmed publisher
Low-density lipoprotein receptor-related protein 2 (LRP2) is a multifunctional cell surface receptor conserved from nematodes to humans...
McCarthy R, Barth J, Chintalapudi M, Knaak C, Argraves W. Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem. 2002;277:25660-7 pubmed
Embryos deficient in the morphogen Sonic hedgehog (Shh) or the endocytic receptor megalin exhibit common neurodevelopmental abnormalities...
Veth K, Willer J, Collery R, Gray M, Willer G, Wagner D, et al
. Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet. 2011;7:e1001310 pubmed publisher
..Lrp2, previously named Megalin, functions as an endocytic receptor for a wide-variety of bioactive molecules including Sonic hedgehog, bone ..
McMahon G, Olden M, Garnaas M, Yang Q, Liu X, Hwang S, et al
. Sequencing of LRP2 reveals multiple rare variants associated with urinary trefoil factor-3. J Am Soc Nephrol. 2014;25:2896-905 pubmed publisher
..Validation in the CKDGen Consortium (n=67,093) showed that only rs7565788 at LRP2, which encodes megalin, was associated with eGFR (P=0.003)...
Reading B, Hiramatsu N, Schilling J, Molloy K, Glassbrook N, Mizuta H, et al
. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. J Lipid Res. 2014;55:2287-95 pubmed publisher
..The presence of lrp13 orthologs in mammals suggests that this lipoprotein receptor is widely distributed among vertebrates, where it may generally play a role in lipoprotein metabolism. ..
Oltrabella F, Pietka G, Ramirez I, Mironov A, Starborg T, Drummond I, et al
. The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. PLoS Genet. 2015;11:e1005058 pubmed publisher
..This coincides with a reduction in levels of the scavenger receptor megalin and its accumulation in endocytic compartments, consistent with reduced recycling within the endocytic pathway...