Gene Symbol: lpin1
Description: lipin 1
Alias: zgc:194552, zgc:194558, phosphatidate phosphatase LPIN1
Gut P, Baeza Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, et al
. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013;9:97-104 pubmed publisher
..Thus, using a whole-organism screening strategy, this study has identified new small-molecule activators of fasting metabolism. ..
Sapp V, Gaffney L, Eauclaire S, Matthews R. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Hepatology. 2014;60:1581-92 pubmed publisher
..Our results indicate that Torc1 activation is required for hepatic lipid accumulation across models of NAFLD, and in patients. ..
Zhang J, Sun P, Kong T, Yang F, Guan W. Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquat Toxicol. 2016;170:208-215 pubmed publisher
..In short, TBT can produce multiple and complex alterations in transcriptional activity of lipid metabolism and cell damage, which provides potential molecular evidence of TBT on hepatic steatosis. ..
Manesia J, Franch M, Tabas Madrid D, Nogales Cadenas R, Vanwelden T, Van Den Bosch E, et al
. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Stem Cells Dev. 2017;26:573-584 pubmed publisher
..In conclusion, we demonstrate that identification of genes involved in transcriptional regulation differentially expressed between expanding FL HSCs and quiescent ABM HSCs, uncovers novel regulators of HSC function. ..