lhx6

Summary

Gene Symbol: lhx6
Description: LIM homeobox 6
Alias: LIM/homeobox protein Lhx6
Species: zebrafish

Top Publications

  1. Mueller T, Wullimann M, Guo S. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008;507:1245-57 pubmed publisher
    We examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain...
  2. Jackman W, Draper B, Stock D. Fgf signaling is required for zebrafish tooth development. Dev Biol. 2004;274:139-57 pubmed
    ..epithelium remained intact as judged by normal pitx2 expression, not only was the mesenchymal expression of lhx6 and lhx7 eliminated as expected from mouse studies, but the epithelial expression of dlx2a, dlx2b, fgf3, and fgf4 ..
  3. Stock D, Jackman W, Trapani J. Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes. Development. 2006;133:3127-37 pubmed publisher
    ..We hypothesize that a loss of Fgf signaling to oral epithelium was associated with cypriniform tooth loss...
  4. Stock D. Zebrafish dentition in comparative context. J Exp Zool B Mol Dev Evol. 2007;308:523-49 pubmed
    ..Such studies may reveal the relative contribution to trends in dental evolution of biases in the generation of variation and sorting of this variation by selection or drift...
  5. Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H, Yoshihara Y. From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. J Neurosci. 2009;29:4756-67 pubmed publisher
    ..Moreover, our finding of asymmetric bulbo-habenular projection renders the olfactory system an attractive model for the studies of brain asymmetry and lateralized behaviors. ..
  6. Swartz M, Sheehan Rooney K, Dixon M, Eberhart J. Examination of a palatogenic gene program in zebrafish. Dev Dyn. 2011;240:2204-20 pubmed publisher
    ..Collectively, these results suggest that the gene regulatory networks regulating palatogenesis may be conserved across vertebrate species, demonstrating the utility of zebrafish as a model for palatogenesis. ..
  7. Gibert Y, Samarut E, Pasco Viel E, Bernard L, Borday Birraux V, Sadier A, et al. Altered retinoic acid signalling underpins dentition evolution. Proc Biol Sci. 2015;282: pubmed publisher
    ..Expression analysis of pharyngeal mesenchyme markers such as dlx2a and lhx6 shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the ..
  8. Wolf A, Ryu S. Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development. 2013;140:1762-73 pubmed publisher
  9. Manoli M, Driever W. nkx2.1 and nkx2.4 genes function partially redundant during development of the zebrafish hypothalamus, preoptic region, and pallidum. Front Neuroanat. 2014;8:145 pubmed publisher
    ..1 is specifically involved in the development of rostral ventral forebrain including the pallidum and preoptic regions, whereas nkx2.4a and nkx2.4b control the intermediate and caudal hypothalamus. ..

More Information

Publications10

  1. Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher
    ..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..