Gene Symbol: lhx2b
Description: LIM homeobox 2b
Alias: bel, lhx2, zgc:152707, LIM/homeobox protein Lhx2, LIM homeobox 2, LIM homeodomain type transcription factor Lhx2, belladonna
Species: zebrafish
Products:     lhx2b

Top Publications

  1. Culverwell J, Karlstrom R. Making the connection: retinal axon guidance in the zebrafish. Semin Cell Dev Biol. 2002;13:497-506 pubmed
    ..The combination of zebrafish genetic and embryological approaches promises to greatly increase our understanding of how multiple guidance mechanisms establish the complex neural interconnectivity of the vertebrate brain. ..
  2. Gahtan E, Baier H. Of lasers, mutants, and see-through brains: functional neuroanatomy in zebrafish. J Neurobiol. 2004;59:147-61 pubmed
    ..Although still in an embryonic stage, the neuroanatomy of behaviors in zebrafish has a bright future. ..
  3. Baier H, Klostermann S, Trowe T, Karlstrom R, Nusslein Volhard C, Bonhoeffer F. Genetic dissection of the retinotectal projection. Development. 1996;123:415-25 pubmed
    ..The results of this screen show that a large-scale genetic approach can be applied to relatively late and circumscribed developmental processes in the vertebrate brain. ..
  4. Seth A, Culverwell J, Walkowicz M, Toro S, Rick J, Neuhauss S, et al. belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development. 2006;133:725-35 pubmed
    ..To better understand axon guidance in the forebrain, we characterized the zebrafish belladonna (bel) mutation, which disrupts commissural and retinal axon guidance in the forebrain...
  5. Ando H, Kobayashi M, Tsubokawa T, Uyemura K, Furuta T, Okamoto H. Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. Dev Biol. 2005;287:456-68 pubmed
    ..b>Lhx2, a LIM-homeodomain protein, and Six3s (Six3b and Six3a), another homeodomain proteins, show very similar expression ..
  6. Karlstrom R, Trowe T, Klostermann S, Baier H, Brand M, Crawford A, et al. Zebrafish mutations affecting retinotectal axon pathfinding. Development. 1996;123:427-38 pubmed
    ..In Class I mutant larvae (belladonna, detour, you-too, iguana, umleitung, blowout) axons grow directly to the ipsilateral tectal lobe after leaving ..
  7. Huang Y, Rinner O, Hedinger P, Liu S, Neuhauss S. Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misrouting. J Neurosci. 2006;26:9873-80 pubmed
    A large fraction of homozygous zebrafish mutant belladonna (bel) larvae display a reversed optokinetic response (OKR) that correlates with failure of the retinal ganglion cells to cross the midline and form the optic chiasm...
  8. Peukert D, Weber S, Lumsden A, Scholpp S. Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling. PLoS Biol. 2011;9:e1001218 pubmed publisher
    ..Here we show that proper neuronal differentiation of the thalamus requires Lhx2 and Lhx9 function...
  9. Beretta C, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez Triana J, et al. Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Curr Biol. 2017;27:270-278 pubmed publisher
    ..This mechanism of network formation may well apply to other circuits, and has only remained undiscovered due to technical limitations. ..

More Information


  1. Förster D, Arnold Ammer I, Laurell E, Barker A, Fernandes A, Finger Baier K, et al. Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Sci Rep. 2017;7:5230 pubmed publisher
    ..Taken together, our study offers new tools for functional studies of specific neural circuits in zebrafish. ..
  2. Muto A, Orger M, Wehman A, Smear M, Kay J, Page McCaw P, et al. Forward genetic analysis of visual behavior in zebrafish. PLoS Genet. 2005;1:e66 pubmed
    ..This collection of zebrafish behavioral mutants provides a novel resource for the study of normal vision and its genetic disorders. ..
  3. Neuhauss S. Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol. 2003;54:148-60 pubmed
    ..Here, I summarize visually mediated behaviors of both larval and adult zebrafish and their applicability for genetic screens, and present, the approaches and results of visual behavior carried out to date. ..
  4. Eichenbaum J, Cinaroglu A, Eichenbaum K, Sadler K. A zebrafish retinal graded photochemical stress model. J Pharmacol Toxicol Methods. 2009;59:121-7 pubmed publisher
    ..The phenotypic and genetic changes observed from this model can serve as a basis for understanding the pathology of retinal oxidative and cellular stress. These changes may aid our understanding of aging and macular degeneration. ..
  5. Takano A, Zochi R, Hibi M, Terashima T, Katsuyama Y. Function of strawberry notch family genes in the zebrafish brain development. Kobe J Med Sci. 2011;56:E220-30 pubmed
    ..Knockdown of sbno1 specifically affects regionalization along the anterior-posterior axis of the brain. These results suggest essential roles of sbno genes in vertebrate brain development. ..
  6. Huber Reggi S, Chen C, Grimm L, Straumann D, Neuhauss S, Huang M. Severity of infantile nystagmus syndrome-like ocular motor phenotype is linked to the extent of the underlying optic nerve projection defect in zebrafish belladonna mutant. J Neurosci. 2012;32:18079-86 pubmed publisher
    ..Likewise, optic nerve misrouting, a reversed OKR and SOs with INS-like waveforms are observed in zebrafish belladonna (bel) mutants...
  7. De Felice E, Porreca I, Alleva E, De Girolamo P, Ambrosino C, Ciriaco E, et al. Localization of BDNF expression in the developing brain of zebrafish. J Anat. 2014;224:564-74 pubmed publisher
    ..Anatomical criteria and co-staining with genetic markers (shh, pax2a, emx1, krox20, lhx2b and lhx9) visualized major topological domains of BDNF-positive cells in the pallium, hypothalamus, posterior ..
  8. Take uchi M, Clarke J, Wilson S. Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity. Development. 2003;130:955-68 pubmed
    ..Finally, we show that Pax2.1 and Vax1/Vax2 are likely to act in parallel downstream of Hh activity and that the bel locus (yet to be cloned) mediates the ability of Hh-, and perhaps Fgf-, signals to induce Vax expression in the ..
  9. Huang Y, Tschopp M, Straumann D, Neuhauss S. Vestibular deficits do not underlie looping behavior in achiasmatic fish. Commun Integr Biol. 2010;3:379-81 pubmed
    Zebrafish belladonna (bel) mutants carry a mutation in the lhx2 gene that encodes a Lim domain homeobox transcription factor, leading to a defect in the retinotectal axon pathfinding...
  10. Ando H, Okamoto H. Efficient transfection strategy for the spatiotemporal control of gene expression in zebrafish. Mar Biotechnol (NY). 2006;8:295-303 pubmed
    ..Co-lipofection of MO and GFP mRNA to the presumptive head region resulted in brain-specific knockdown of the gene in mid-stage embryos. ..
  11. Chen L, Zheng J, Yang N, Li H, Guo S. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011;286:18641-9 pubmed publisher
    ..function, gain of function, and chromatin immunoprecipitation, we further identified and validated eomesa/tbr2 and lhx2b as biologically relevant target genes of Fezf2...