Gene Symbol: leopard
Description: gap junction protein, alpha 5b
Alias: cx41.8, gap junction alpha-5 protein, connexin 41.8, leo, leopard, tup
Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, et al
. Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene. EMBO Rep. 2006;7:893-7 pubmed
b>Leopard, a well-known zebrafish mutant that has a spotted skin pattern instead of stripes, is a model for the study of pigment patterning...
Watanabe M, Kondo S. Changing clothes easily: connexin41.8 regulates skin pattern variation. Pigment Cell Melanoma Res. 2012;25:326-30 pubmed publisher
..including a narrow stripe with a wide interstripe, a narrow stripe with a narrow interstripe, a labyrinth, and a 'leopard' pattern (or donut-like ring pattern). In this process, connexin41...
Watanabe M, Watanabe D, Kondo S. Polyamine sensitivity of gap junctions is required for skin pattern formation in zebrafish. Sci Rep. 2012;2:473 pubmed publisher
..This is the first report to show that polyamine sensitivity has a physiologically relevant function and is related to skin pattern formation in animals. ..
Iovine M, Gumpert A, Falk M, Mendelson T. Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS Lett. 2008;582:165-70 pubmed
..Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro. ..
Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, et al
. Mutations affecting pigmentation and shape of the adult zebrafish. Dev Genes Evol. 1996;206:260-76 pubmed publisher
..The adult pigment pattern was found to be changed by dominant mutations in wanda, asterix, obelix, leopard, salz and pfeffer...
Watanabe M, Sawada R, Aramaki T, Skerrett I, Kondo S. The Physiological Characterization of Connexin41.8 and Connexin39.4, Which Are Involved in the Striped Pattern Formation of Zebrafish. J Biol Chem. 2016;291:1053-63 pubmed publisher
..Our results suggest that functional differences in Cx41.8 and Cx39.4 relate to spot or labyrinth mutant phenotypes and also provide evidence that these two connexins interact in vivo and in vitro. ..
Eom D, Bain E, Patterson L, Grout M, Parichy D. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. elife. 2015;4: pubmed publisher
..Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form. ..
Canzian J, Fontana B, Quadros V, Rosemberg D. Conspecific alarm substance differently alters group behavior of zebrafish populations: Putative involvement of cholinergic and purinergic signaling in anxiety- and fear-like responses. Behav Brain Res. 2017;320:255-263 pubmed publisher
..The short fin wild type (WT), and leopard (leo) are two zebrafish populations that present several behavioral differences, in which leo displays pronounced ..
Irion U, FrohnhÃ¶fer H, Krauss J, Ã‡olak Champollion T, Maischein H, Geiger Rudolph S, et al
. Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish. elife. 2014;3:e05125 pubmed publisher
..Mutations in leopard (leo), encoding Connexin 41.8 (Cx41.8), a gap junction subunit, cause a phenotypic series of spotted patterns...