Gene Symbol: leg1.2
Description: liver-enriched gene 1, tandem duplicate 2
Alias: Leg1-B, zgc:77778, protein leg1b, UPF0762 protein C6orf58 homolog, leg1b, liver-enriched gene protein 1-B
Chang C, Hu M, Zhu Z, Lo L, Chen J, Peng J. liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in zebrafish. PLoS ONE. 2011;6:e22910 pubmed publisher
..There are two copies of leg1 in zebrafish, namely leg1a and leg1b. Both leg1a and leg1b are expressed in the larvae and adult liver with leg1a being the predominant form...
Babaei F, Ramalingam R, Tavendale A, Liang Y, Yan L, Ajuh P, et al
. Novel blood collection method allows plasma proteome analysis from single zebrafish. J Proteome Res. 2013;12:1580-90 pubmed publisher
..Twenty-seven gender-dependent plasma proteins are identified and their biochemical importance discussed. Taken together, this novel technique enables analyses that were previously difficult to perform on zebrafish blood. ..
Driessen M, Kienhuis A, Vitins A, Pennings J, Pronk T, van den Brandhof E, et al
. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicol Lett. 2014;230:48-56 pubmed publisher
..In conclusion, the ZFE model allows for identification of hepatotoxicants, without discrimination into specific phenotypes. ..
Hu M, Bai Y, Zhang C, Liu F, Cui Z, Chen J, et al
. Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genet. 2016;12:e1005881 pubmed publisher
..In the zebrafish genome, there are two copies of leg1, namely leg1a and leg1b. leg1a and leg1b are closely linked on chromosome 20 and share high homology, but are differentially expressed...