Gene Symbol: ldha
Description: lactate dehydrogenase A4
Alias: L-lactate dehydrogenase A chain, LDH-A, ldha1
Species: zebrafish
Products:     ldha

Top Publications

  1. Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
    ..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
  2. Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
    ..Globin X mRNA level was highest in oocytes, but low in later stages. Together, these data suggest a specific role for each globin, which are also associated with certain events in fish development. ..
  3. Khayrullin A, Smith L, Mistry D, Dukes A, Pan Y, Hamrick M. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochem Biophys Res Commun. 2016;479:590-595 pubmed publisher
    ..Furthermore, zebrafish may serve as a useful model for better understanding the role of microRNAs in alcohol-related tissue damage. ..
  4. Marín Juez R, Marass M, Gauvrit S, Rossi A, Lai S, Materna S, et al. Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2016;113:11237-11242 pubmed
    ..Our work also paves the way for future studies designed to understand the molecular mechanisms that regulate fast revascularization. ..
  5. Xu T, Zhao J, Xu Z, Pan R, Yin D. The developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view. Sci Rep. 2016;6:25929 pubmed publisher
    ..Our study attempted to describe the developmental toxicity of environmental pollutants from a systematic view. Meanwhile, some features of gene expression profiling could serve as markers of human health or ecological risk. ..
  6. Li Z, Zheng W, Li H, Li C, Gong Z. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS ONE. 2015;10:e0132319 pubmed publisher
    ..Critical glycolytic genes including hk2, pkm and ldha were significantly up-regulated in Myc/xmrk tumors but not in either single oncogene-induced tumors, suggesting a ..
  7. Ton C, Stamatiou D, Dzau V, Liew C. Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. Biochem Biophys Res Commun. 2002;296:1134-42 pubmed
    ..Our study provides the first utilization of cDNA microarray in the zebrafish and reveals dynamic changes in levels of gene expression in relation to development and survival of the zebrafish embryos under hypoxic stress. ..
  8. Ngan A, Wang Y. Tissue-specific transcriptional regulation of monocarboxylate transporters (MCTs) during short-term hypoxia in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2009;154:396-405 pubmed publisher
    ..over 48 and 96h and measured tissue-specific transcriptional changes of MCTs (1, 2 and 4), lactate dehydrogenase A (LDHa), citrate synthase (CS), and other metabolic proteins using real-time RT-PCR...
  9. Guan B, Ma H, Wang Y, Hu Y, Lin Z, Zhu Z, et al. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar Biotechnol (NY). 2011;13:336-44 pubmed publisher
    ..These results suggest that that vhb gene may be an efficient candidate for genetically modifying hypoxia tolerance in fish. ..

More Information


  1. Jain I, Zazzeron L, Goli R, Alexa K, Schatzman Bone S, Dhillon H, et al. Hypoxia as a therapy for mitochondrial disease. Science. 2016;352:54-61 pubmed publisher
    ..Further preclinical studies are required to assess whether hypoxic exposure can be developed into a safe and effective treatment for human diseases associated with mitochondrial dysfunction. ..
  2. Almeida D, Bianchini A, Marins L. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Gen Comp Endocrinol. 2013;194:102-9 pubmed publisher
    ..Taken together, these findings indicate that GH-transgenesis impaired the ability of juvenile zebrafish to sustain an aerobic metabolism and induced anaerobic metabolism when the fish were challenged with low oxygen levels. ..
  3. Liu X, Cai X, Hu B, Mei Z, Zhang D, Ouyang G, et al. Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). J Biol Chem. 2016;291:25692-25705 pubmed
    ..In conclusion, our findings suggest that, by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress. ..
  4. Tiedke J, Cubuk C, Burmester T. Environmental acidification triggers oxidative stress and enhances globin expression in zebrafish gills. Biochem Biophys Res Commun. 2013;441:624-9 pubmed publisher
    ..These findings agree with the role of globins in oxidative energy metabolism, but may also hint at a specific function in antioxidative defense. ..
  5. van der Velden Y, Wang L, Zevenhoven J, van Rooijen E, Van Lohuizen M, Giles R, et al. The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proc Natl Acad Sci U S A. 2011;108:4358-63 pubmed publisher
    ..Zebrafish models of Lkb1 inactivation could provide a platform for chemical genetic screens to identify compounds that target accelerated metabolism, a key feature of tumor cells. ..
  6. Li Y, Tsoi S, Mannen H, Shoei Lung Li S. Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. J Mol Evol. 2002;54:614-24 pubmed
    ..Other gene duplication events were also discovered in Xenopus, the first duplication occurring approximately 60-70 mya in both Ldh-A and Ldh-B, followed by another recent gene duplication event, approximately 20 mya, in Ldh-B. ..
  7. Xu T, Zhao J, Hu P, Dong Z, Li J, Zhang H, et al. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicol Appl Pharmacol. 2014;277:183-91 pubmed publisher
    ..Taken together, our results demonstrated that PCP causes a Warburg-like effect on zebrafish embryos during gastrulation, and the affected embryos had the phenotype of developmental delay...
  8. Chai T, Cui F, Mu P, Yang Y, Xu N, Yin Z, et al. Enantio-alteration of gene transcription associated with bioconcentration in adult zebrafish (Danio rerio) exposed to chiral PCB149. Sci Rep. 2016;6:19478 pubmed publisher
    ..Hepatic expression levels of genes related to the antioxidant system were significantly negatively correlated with bioconcentration following exposure to (+)-PCB149. ..
  9. Hyvärinen J, Parikka M, Sormunen R, Ramet M, Tryggvason K, Kivirikko K, et al. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. J Biol Chem. 2010;285:42023-32 pubmed publisher
    ..Many HIF target genes were induced in the P4H-TM-deficient morphants, but the observed phenotype is not likely to be mediated at least solely via the HIF pathway, and thus P4H-TM probably has additional, as yet unknown, substrates. ..
  10. Martinovic D, Villeneuve D, Kahl M, Blake L, Brodin J, Ankley G. Hypoxia alters gene expression in the gonads of zebrafish (Danio rerio). Aquat Toxicol. 2009;95:258-72 pubmed publisher
    ..g., hydroxysteroid dehydrogenase alterations, downregulation of contractile elements, etc.). ..
  11. McClelland G, Craig P, Dhekney K, Dipardo S. Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J Physiol. 2006;577:739-51 pubmed
    ..e. CS and PPAR-beta1 mRNA) that contribute to specific temperature- and exercise-induced phenotypes. ..
  12. Almeida D, De Martinez Gaspar Martins C, de Azevedo Figueiredo M, Lanes C, Bianchini A, Marins L. Growth hormone transgenesis affects osmoregulation and energy metabolism in zebrafish (Danio rerio). Transgenic Res. 2013;22:75-88 pubmed publisher
  13. Chai T, Cui F, Mu X, Yang Y, Wang C, Qiu J. Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels. PLoS ONE. 2016;11:e0155263 pubmed publisher
    ..Thus, the information in our study could provide new insights to assess the environmental risk of chiral PCBs in aquatic systems. ..
  14. Wu Z, Zhang W, Lu Y, Lu C. Transcriptome profiling of zebrafish infected with Streptococcus suis. Microb Pathog. 2010;48:178-87 pubmed publisher
    ..The data may provide further validation of this model, which will contribute to understanding of S. suis pathogenic mechanisms. ..
  15. Vettori A, Greenald D, Wilson G, Peron M, Facchinello N, Markham E, et al. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1? stabilization. Proc Natl Acad Sci U S A. 2017;114:9948-9953 pubmed publisher
    ..Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL. ..
  16. Sandoval I, Delacruz R, Miller B, Hill S, Olson K, Gabriel A, et al. A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). elife. 2017;6: pubmed publisher
    ..Our data demonstrate a novel role for apc in pyruvate metabolism and that pyruvate metabolism dictates intestinal cell fate and differentiation decisions downstream of apc. ..