Gene Symbol: krt8
Description: keratin 8
Alias: DreK8, cb186, krt2-8, sb:cb186, wu:fa20h05, wu:fa95h10, wu:fb96c06, zf-K8, zfk8, keratin, type II cytoskeletal 8, CK-8, cytokeratin-8, etID33550.23, etID43142.23, etID43142.8, keratin, type 2, gene 8
Species: zebrafish
Products:     krt8

Top Publications

  1. Fukazawa C, Santiago C, Park K, Deery W, Gomez de la Torre Canny S, Holterhoff C, et al. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis. Dev Biol. 2010;346:272-83 pubmed publisher
  2. Parinov S, Kondrichin I, Korzh V, Emelyanov A. Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo. Dev Dyn. 2004;231:449-59 pubmed
    ..The approach has great potential for developmental and anatomical studies of teleosts. ..
  3. Gong Z, Ju B, Wang X, He J, Wan H, Sudha P, et al. Green fluorescent protein expression in germ-line transmitted transgenic zebrafish under a stratified epithelial promoter from keratin8. Dev Dyn. 2002;223:204-15 pubmed
    A zebrafish cDNA encoding a novel keratin protein was characterized and named keratin8, or krt8. krt8 expression was initiated at 4.5 hr postfertilization, immediately after the time of zygotic genome activation...
  4. Tsujimura T, Chinen A, Kawamura S. Identification of a locus control region for quadruplicated green-sensitive opsin genes in zebrafish. Proc Natl Acad Sci U S A. 2007;104:12813-8 pubmed
    ..5-kb region in the PAC clone conferred the highest expression for its proximal gene. The 0.5-kb region was thus designated as RH2-LCR analogous to the locus control region of the L-M opsin genes of primates. ..
  5. Krushna Padhi B, Akimenko M, Ekker M. Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene. 2006;368:37-45 pubmed
    ..This contrasts with other members of the keratin gene family, which diverged independently between fish and mammals. ..
  6. Huang T, Chen J. Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1. Fish Shellfish Immunol. 2013;34:593-8 pubmed publisher
    ..Our findings imply that epinecidin-1 may stabilize the cytoskeleton network in host cells, thereby promoting resistance to bacterial infection. ..
  7. Simões M, Bensimon Brito A, Fonseca M, Farinho A, Valério F, Sousa S, et al. Denervation impairs regeneration of amputated zebrafish fins. BMC Dev Biol. 2014;14:49 pubmed publisher
  8. Chen C, Lin D, Cheng C, Lin C, Lo Y, Yen C, et al. Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget. 2014;5:6300-11 pubmed
    ..Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug. ..
  9. Wan H, He J, Ju B, Yan T, Lam T, Gong Z. Generation of two-color transgenic zebrafish using the green and red fluorescent protein reporter genes gfp and rfp. Mar Biotechnol (NY). 2002;4:146-54 pubmed
    ..Our study demonstrates the feasibility of monitoring expression of multiple genes in different tissues in the same transgenic organism. ..

More Information


  1. Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, et al. Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. J Cell Sci. 2012;125:1129-40 pubmed publisher
    ..This study identifies the importance of the syntenin-syndecan-PIP2-Arf6 complex for the progression of fish epiboly and establishes its key role in directional cell movements during early development. ..
  2. Li X, Nie F, Yin Z, He J. Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1. Sci China Life Sci. 2011;54:159-65 pubmed publisher
    ..Our findings suggest that Fst1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia. ..
  3. Nowak M, Koster C, Hammerschmidt M. Perp is required for tissue-specific cell survival during zebrafish development. Cell Death Differ. 2005;12:52-64 pubmed
    ..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival. ..
  4. Tsujimura T, Hosoya T, Kawamura S. A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish. PLoS Genet. 2010;6:e1001245 pubmed publisher
    ..Sharing a regulatory region between duplicated genes could be a general way to facilitate the expression differentiation in duplicated visual opsins. ..
  5. Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, et al. p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet. 2014;10:e1004048 pubmed publisher
  6. Garcia D, Bauer H, Dietz T, Schubert T, Markl J, Schaffeld M. Identification of keratins and analysis of their expression in carp and goldfish: comparison with the zebrafish and trout keratin catalog. Cell Tissue Res. 2005;322:245-56 pubmed
  7. Schaffeld M, Knappe M, Hunzinger C, Markl J. cDNA sequences of the authentic keratins 8 and 18 in zebrafish. Differentiation. 2003;71:73-82 pubmed
    ..From the zebrafish Danio rerio, we have cDNA cloned and sequenced a novel type II and a novel type I keratin, termed DreK8 and DreK18, respectively...
  8. Tong X, Xia Z, Zu Y, Telfer H, Hu J, Yu J, et al. ngs (notochord granular surface) gene encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. J Biol Chem. 2013;288:2711-20 pubmed publisher
    ..Our work sheds light on the mechanisms of notochord structural maintenance, as well as the evolution and biological function of IF family proteins. ..
  9. Imboden M, Goblet C, Korn H, Vriz S. Cytokeratin 8 is a suitable epidermal marker during zebrafish development. C R Acad Sci III. 1997;320:689-700 pubmed
    We have cloned and characterized the zebrafish (Danio rerio) homologous cytokeratin 8 (zf-K8) cDNA. This cytokeratin belongs to the gene family of intermediate filaments and it is a component of the cytoskeleton of epithelial cells...
  10. Emelyanov A, Parinov S. Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish. Dev Biol. 2008;320:113-21 pubmed publisher
    ..Combined with the Ac/Ds-mediated transgenesis, the LexPR expression system has many potential applications in the fields of genetics and biotechnology. ..
  11. Goto H, Kimmey S, Row R, Matus D, Martin B. FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Development. 2017;144:1412-1424 pubmed publisher
    ..Wnt signaling initiates EMT, whereas FGF signaling terminates this event. Our results indicate that germ layer induction in the zebrafish tailbud is not a simple continuation of gastrulation events. ..
  12. Sabel J, d Alençon C, O Brien E, Van Otterloo E, Lutz K, Cuykendall T, et al. Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos. Dev Biol. 2009;325:249-62 pubmed publisher
    ..These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio. This epithelium constitutes a novel model tissue in which to explore the Irf6 regulatory pathway. ..
  13. Dzafic E, Strzyz P, Wilsch Bräuninger M, Norden C. Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells. Cell Rep. 2015;13:168-182 pubmed publisher
    ..Once cells reach the differentiation phase, however, centriole amplification does not impair neuronal differentiation. ..
  14. Shi G, Sohn K, Choi T, Choi D, Lee S, Ou B, et al. Expression of paired-like homeodomain transcription factor 2c (PITX2c) in epidermal keratinocytes. Exp Cell Res. 2010;316:3263-71 pubmed publisher
    ..These results suggest that PITX2c has a role in proliferation and differentiation of epidermal keratinocytes. ..
  15. Quek S, Chan W. Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b. J Mol Endocrinol. 2009;43:121-30 pubmed publisher
  16. Schwend T, Loucks E, Snyder D, Ahlgren S. Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish. J Lipid Res. 2011;52:1328-44 pubmed publisher
    ..Collectively, these studies show that npc1 is required early for proper cell movement and cholesterol localization and later for cell survival. ..
  17. Gündel U, Kalkhof S, Zitzkat D, von Bergen M, Altenburger R, Küster E. Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicol Environ Saf. 2012;76:11-22 pubmed publisher
    ..Using this experimental design based on testing of several exposure concentrations and less replicates might provide a step forward in getting increased output from toxicoproteomics studies. ..
  18. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Probing FoxH1 morphant RNA by microarray, we identified a cohort of five keratin genes--cyt1, cyt2, krt4, krt8 and krt18--that are normally transcribed in the embryo's enveloping layer (EVL) and which have significantly ..
  19. Podok P, Wang H, Xu L, Xu D, Lu L. Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in the resistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection. Fish Shellfish Immunol. 2014;41:531-40 pubmed publisher
    ..These findings also support the use of MPO and KRT-8 as immunological markers for a response to viral infection in crucian carp. ..
  20. Seleit A, Krämer I, Riebesehl B, Ambrosio E, Stolper J, Lischik C, et al. Neural stem cells induce the formation of their physical niche during organogenesis. elife. 2017;6: pubmed publisher
    ..We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches. ..
  21. Martorana M, Tawk M, Lapointe T, Barre N, Imboden M, Joulie C, et al. Zebrafish keratin 8 is expressed at high levels in the epidermis of regenerating caudal fin. Int J Dev Biol. 2001;45:449-52 pubmed
    ..We previously cloned and characterised the zebrafish (Danio rerio) homologous cytokeratin 8 cDNA (zfk8) which was described as an epidermal marker during zebrafish development...
  22. Ling X, Lu Y, Huang H. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Environ Sci Pollut Res Int. 2012;19:3925-41 pubmed publisher
    ..The results may also provide the possibility of the establishment of candidate biomarkers for monitoring MP and Cd contamination in water. ..