krt5

Summary

Gene Symbol: krt5
Description: keratin 5
Alias: ckii, wu:fb02h09, wu:fj02d02, wu:fk78b12, zfCKII, keratin 5, type II cytokeratin
Species: zebrafish
Products:     krt5

Top Publications

  1. Krushna Padhi B, Akimenko M, Ekker M. Independent expansion of the keratin gene family in teleostean fish and mammals: an insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene. 2006;368:37-45 pubmed
    ..This contrasts with other members of the keratin gene family, which diverged independently between fish and mammals. ..
  2. Wang Y, Chen Y, Lu J, Lin Y, Chang M, Tsai H. Epidermis-restricted expression of zebrafish cytokeratin II is controlled by a -141/+85 minimal promoter, and cassette -141/-111 is essential for driving the tissue specificity. Differentiation. 2006;74:186-94 pubmed
    We isolated a 2.3 kb DNA segment from the upstream region of the zebrafish cytokeratin II (zfCKII) gene...
  3. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling. ..
  4. Hu B, Zhang C, Baawo K, Qin R, Cole G, Lee J, et al. Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research. Oral Oncol. 2010;46:31-7 pubmed publisher
    ..In situ hybridization showed that keratin 5, a marker of the basal cell layer of mammalian oral epithelium, was expressed in the squamous epithelium of ..
  5. Reischauer S, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis. PLoS Genet. 2009;5:e1000720 pubmed publisher
    ..Our data reveal that pen/lgl2 functions as a tumor suppressor gene in vertebrates, establishing zebrafish pen/lgl2 mutants as a valuable cancer model. ..
  6. Gündel U, Kalkhof S, Zitzkat D, von Bergen M, Altenburger R, Küster E. Concentration-response concept in ecotoxicoproteomics: effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicol Environ Saf. 2012;76:11-22 pubmed publisher
    ..Using this experimental design based on testing of several exposure concentrations and less replicates might provide a step forward in getting increased output from toxicoproteomics studies. ..
  7. Akerberg A, Stewart S, Stankunas K. Spatial and temporal control of transgene expression in zebrafish. PLoS ONE. 2014;9:e92217 pubmed publisher
    ..Given the array of existing UAS lines, the modular nature of this system will enable many previously intractable zebrafish experiments. ..
  8. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  9. Saxena S, Singh S, Lakshmi M, Meghah V, Bhatti B, Swamy C, et al. Proteomic analysis of zebrafish caudal fin regeneration. Mol Cell Proteomics. 2012;11:M111.014118 pubmed publisher
    ..The obtained differential proteome and the direct association of the various proteins might lead to a new understanding of the regeneration mechanism. ..

More Information

Publications23

  1. Chen H, Beasley A, Hu Y, Chen X. A Zebrafish Model for Studies on Esophageal Epithelial Biology. PLoS ONE. 2015;10:e0143878 pubmed publisher
    ..Expression of esophageal epithelial marker genes (Krt5, P63, Sox2 and Pax9) was detected by immunohistochemistry and in situ hybridization...
  2. Doğanlı C, Beck H, Ribera A, Oxvig C, Lykke Hartmann K. ?3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish. J Biol Chem. 2013;288:8862-74 pubmed publisher
    ..Our data thus strongly support the role of ?3Na(+)/K(+)-ATPase in zebrafish motility and brain development, associating for the first time the ?3Na(+)/K(+)-ATPase deficiency with brain ventricle dilation. ..
  3. Rasmussen J, Sack G, Martin S, Sagasti A. Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. J Neurosci. 2015;35:559-70 pubmed publisher
    ..Together, these results identify vertebrate epidermal cells as broad-specificity phagocytes that likely contribute to neural repair and wound healing. ..
  4. Falisse E, Voisin A, Silvestre F. Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Aquat Toxicol. 2017;189:97-107 pubmed publisher
    ..This research highlighted oxidative stress and neurotoxicity as major toxicity mechanisms of TCS during development. ..
  5. Ju B, Chen W, Orr B, Spitsbergen J, Jia S, Eden C, et al. Oncogenic KRAS promotes malignant brain tumors in zebrafish. Mol Cancer. 2015;14:18 pubmed publisher
    ..Using zebrafish cytokeratin 5 (krt5) and glial fibrillary acidic protein (gfap) gene promoters, we activated Ras signaling in the zebrafish central ..
  6. Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, et al. p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet. 2014;10:e1004048 pubmed publisher
  7. Tong X, Xia Z, Zu Y, Telfer H, Hu J, Yu J, et al. ngs (notochord granular surface) gene encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. J Biol Chem. 2013;288:2711-20 pubmed publisher
    ..Our work sheds light on the mechanisms of notochord structural maintenance, as well as the evolution and biological function of IF family proteins. ..
  8. Wagner K, Ying Y, Leong W, Jiang J, Hu X, Chen Y, et al. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Aging (Albany NY). 2017;9:1219-1232 pubmed publisher
    ..Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging. ..
  9. Chua K, Lim T. Type I and type II cytokeratin cDNAs from the zebrafish (Danio rerio) and expression patterns during early development. Differentiation. 2000;66:31-41 pubmed
    Full-length cDNAs of a type I (zfCKI), and a type II (zfCKII) cytokeratin from the adult zebrafish, Danio rerio, were characterized and their expressions studied during early development and in the adult...
  10. Hu B, Chen H, Liu X, Zhang C, Cole G, Lee J, et al. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish. 2013;10:218-27 pubmed publisher
    ..epithelium, a transgenic zebrafish system was developed by expressing cdx1b gene under the control of zebrafish keratin 5 promoter (krt5p)...
  11. Schaffeld M, Haberkamp M, Braziulis E, Lieb B, Markl J. Type II keratin cDNAs from the rainbow trout: implications for keratin evolution. Differentiation. 2002;70:292-9 pubmed
    ..The tree also indicates that the published zebrafish sequences represent IIe keratins and that the biochemically identified K8 ortholog in zebrafish has not yet been sequenced. ..
  12. Chen C, Lin D, Cheng C, Lin C, Lo Y, Yen C, et al. Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget. 2014;5:6300-11 pubmed
    ..Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug. ..
  13. Ju B, Chen W, Spitsbergen J, Lu J, Vogel P, Peters J, et al. Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis. 2014;3:e96 pubmed publisher
    ..In conclusion, we demonstrate that activated Shh signaling initiates tumorigenesis in the zebrafish CNS and provide the first OPG model not associated with neurofibromatosis 1. ..
  14. Li M, Cheng R, Liang J, Yan H, Zhang H, Yang L, et al. Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease. Am J Hum Genet. 2013;92:895-903 pubmed publisher
    ..Loss-of-function mutations of keratin 5 (KRT5) have been identified in DDD individuals...