Gene Symbol: klf1
Description: Kruppel-like factor 1 (erythroid)
Alias: klfd, zgc:194069, Kruppel-like factor 1 (erythroid), Kruppel-like factor d
Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D. Cold exposure down-regulates zebrafish hematopoiesis. Biochem Biophys Res Commun. 2010;394:859-64 pubmed publisher
..hematopoietic transcription factors (Runx1, scl, c-myb and GATA-2) and particularly erythropoiesis-related factors (klfd, hbaa1, ba1, GATA-1, EPO, and EPOr) was down-regulated, whereas myelopoiesis-related factors (csf1a and csf3) was ..
Chervenak A, Basu P, Shin M, Redmond L, Sheng G, Lloyd J. Identification, characterization, and expression pattern of the chicken EKLF gene. Dev Dyn. 2006;235:1933-40 pubmed
EKLF/KLF1 was the first of the Krüppel-like factors (KLFs) to be identified in mammals and plays an important role in primitive and definitive erythropoiesis. Here, we identify and characterize EKLF in the chicken (cEKLF)...
Shao M, Ge G, Liu W, Xiao J, Xia H, Fan Y, et al
. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Oncotarget. 2017;8:16325-16339 pubmed publisher
..TbKLF5, like hKLF5, significantly promotes NIH3T3 cell proliferation in vitro. These results provide insight for future studies regarding the structure and function of the tbKLF gene family. ..
Yergeau D, Cornell C, Parker S, Zhou Y, Detrich H. bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in zebrafish. Dev Biol. 2005;283:97-112 pubmed
..We conclude that bty is likely to play a role in differentiation of the committed red cell progenitor. ..
Takeuchi M, Fuse Y, Watanabe M, Andrea C, Takeuchi M, Nakajima H, et al
. LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proc Natl Acad Sci U S A. 2015;112:13922-7 pubmed publisher
..Our results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation. ..
Nishikawa K, Kobayashi M, Masumi A, Lyons S, Weinstein B, Liu P, et al
. Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Mol Cell Biol. 2003;23:8295-305 pubmed
..These results thus provide the first in vivo evidence that the ability of Gata1 to self-associate critically contributes to the autoregulation of the gata1 gene. ..
Wallace K, Dolan A, Seiler C, Smith E, Yusuff S, Chaille Arnold L, et al
. Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Dev Cell. 2005;8:717-26 pubmed
..Furthermore, they suggest that high-throughput screens to identify regulators of cancer cell invasion may be feasible in zebrafish. ..