Gene Symbol: kitlga
Description: kit ligand a
Alias: kitla, kit ligand, slk
Species: zebrafish

Top Publications

  1. O Reilly Pol T, Johnson S. Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos. Development. 2013;140:996-1002 pubmed publisher
    ..Our analysis suggests that the kit MSC establishment defect results from inappropriate differentiation of the MSC lineage. ..
  2. Budi E, Patterson L, Parichy D. Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genet. 2011;7:e1002044 pubmed publisher
    ..These findings provide a foundation for future studies of post-embryonic pigment cell precursors in development, evolution, and neoplasia...
  3. Hultman K, Bahary N, Zon L, Johnson S. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet. 2007;3:e17 pubmed
    ..We examine the partitioning of expression patterns and functions of two zebrafish kit ligands, kit ligand a (kitla) and kit ligand b (kitlb), and discuss their possible coevolution with the duplicated zebrafish kit ..
  4. Yao K, Ge W. Kit system in the zebrafish ovary: evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligand (kitlga and kitlgb) during folliculogenesis. Biol Reprod. 2010;82:1216-26 pubmed publisher
    The Kit system, including Kit ligand and its receptor Kit, has critical roles in mammalian reproduction, especially in the ovary...
  5. Hultman K, Budi E, Teasley D, Gottlieb A, Parichy D, Johnson S. Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genet. 2009;5:e1000544 pubmed publisher
    ..We then show that overexpression of kitla, the Kit ligand, in transgenic larvae leads to recruitment of MSCs, resulting in overproliferation of melanocytes...
  6. Kelsh R, Brand M, Jiang Y, Heisenberg C, Lin S, Haffter P, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-89 pubmed
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  7. Dooley C, Mongera A, Walderich B, NUSSLEIN VOLHARD C. On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development. 2013;140:1003-13 pubmed publisher
    ..We show that the sparse like (slk) mutant lacks larval and metamorphic melanophores and identify kit ligand a (kitlga) as the underlying gene...
  8. Patterson L, Bain E, Parichy D. Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nat Commun. 2014;5:5299 pubmed publisher
    ..Our results identify novel mechanisms of pattern development and illustrate how pattern diversity can be generated when a core network of pigment-cell autonomous interactions is coupled with changes in pigment cell differentiation. ..
  9. Yao K, Ge W. Differential regulation of kit ligand A (kitlga) expression in the zebrafish ovarian follicle cells--evidence for the existence of a cyclic adenosine 3', 5' monophosphate-mediated binary regulatory system during folliculogenesis. Mol Cell Endocrinol. 2015;402:21-31 pubmed publisher
    b>Kit ligand (Kitl) is an important paracrine factor involved in the activation of primordial follicles from the quiescent pool and in the maintenance of meiotic arrest before germinal vesicle breakdown (GVBD)...

More Information


  1. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase. ..
  2. Rich A, Leddon S, Hess S, Gibbons S, Miller S, Xu X, et al. Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Dev Dyn. 2007;236:903-11 pubmed
    ..specifically designed to amplify mRNA coding for two zebrafish kit genes, kita and kitb, and two kit ligands, kitla and kitlb, amplified the expected transcript from total RNA isolated from zebrafish GI tissues...
  3. Yao K, Ge W. Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle. PLoS ONE. 2013;8:e56192 pubmed publisher
    Consisting of Kit ligand and receptor Kit, the Kit system is involved in regulating many ovarian functions such as follicle activation, granulosa cell proliferation, and oocyte growth and maturation...
  4. Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 2013;9:e1003561 pubmed publisher that bnc2 promotes melanophore and xanthophore development by regulating expression of the growth factors Kit ligand a (Kitlga) and Colony stimulating factor-1 (Csf1), respectively...
  5. Tryon R, Johnson S. Clonal analysis of kit ligand a functional expression reveals lineage-specific competence to promote melanocyte rescue in the mutant regenerating caudal fin. PLoS ONE. 2014;9:e102317 pubmed publisher
    ..example to demonstrate this approach, we explored which lineages were competent to functionally express the kit ligand a protein as assessed by the local complementation of the mutation in the sparse-like (kitlgatc244b) background...
  6. Yin C, Evason K, Maher J, Stainier D. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver. Hepatology. 2012;56:1958-70 pubmed publisher
    ..The Tg(hand2:EGFP) line represents a unique tool for in vivo analysis and molecular dissection of HSC behavior. ..
  7. Yao K, Lau S, Ge W. Differential regulation of Kit ligand A expression in the ovary by IGF-I via different pathways. Mol Endocrinol. 2014;28:138-50 pubmed publisher
    b>Kit ligand (KITL) plays indispensable roles both in primordial follicle activation and in the maintenance of meiotic arrest of the oocyte. The regulation of KITL expression in the ovary, however, remains largely unknown...
  8. Eom D, Bain E, Patterson L, Grout M, Parichy D. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. elife. 2015;4: pubmed publisher
    ..Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form. ..
  9. Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
    ..The full comprehension of the mechanisms induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative purposes. ..