Gene Symbol: kitb
Description: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
Alias: kit receptor b, type III tyrosine kinase
Species: zebrafish
Products:     kitb

Top Publications

  1. Mellgren E, Johnson S. kitb, a second zebrafish ortholog of mouse Kit. Dev Genes Evol. 2005;215:470-77 pubmed
    ..notion by identification and analysis of a second zebrafish ortholog of the mammalian Kit receptor tyrosine kinase (kitb)...
  2. Yao K, Ge W. Kit system in the zebrafish ovary: evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligand (kitlga and kitlgb) during folliculogenesis. Biol Reprod. 2010;82:1216-26 pubmed publisher
    ..two copies of genes are present in the zebrafish genome for both ligand (kitlga and kitlgb) and receptor (kita and kitb)...
  3. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis. ..
  4. Rich A, Leddon S, Hess S, Gibbons S, Miller S, Xu X, et al. Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Dev Dyn. 2007;236:903-11 pubmed
    ..Primers specifically designed to amplify mRNA coding for two zebrafish kit genes, kita and kitb, and two kit ligands, kitla and kitlb, amplified the expected transcript from total RNA isolated from zebrafish GI ..
  5. Yao K, Ge W. Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle. PLoS ONE. 2013;8:e56192 pubmed publisher
    ..In the zebrafish, the Kit system contains two ligands (Kitlga and Kitlgb) and two receptors (Kita and Kitb)...
  6. Pilorge M, Fassier C, Le Corronc H, Potey A, Bai J, De Gois S, et al. Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Mol Psychiatry. 2016;21:936-45 pubmed publisher
    ..Taken together, these results implicate GLRA2 in non-syndromic ASD, unveil a novel role for GLRA2 in synaptic plasticity and learning and memory, and link altered glycinergic signaling to social and cognitive impairments. ..
  7. Siegel N, Hoegg S, Salzburger W, Braasch I, Meyer A. Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications. BMC Genomics. 2007;8:312 pubmed
  8. Staudt N, Müller Sienerth N, Fane Dremucheva A, Yusaf S, Millrine D, Wright G. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Biochem Biophys Res Commun. 2015;456:527-33 pubmed publisher
    ..The antibodies and the approaches described here will help to address the lack of well-defined antibody reagents in zebrafish research. ..
  9. de Preux Charles A, Bise T, Baier F, Marro J, Jazwinska A. Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart. Open Biol. 2016;6: pubmed publisher
    ..Taken together, our results show that, while the immune response is not necessary to induce cell-cycle activity in intact preconditioned hearts, inflammation is required for the regeneration of injured hearts in zebrafish. ..

More Information


  1. Mellgren E, Johnson S. A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay. Dev Genes Evol. 2004;214:493-502 pubmed
    ..Finally, we suggest there is a heterochronic shift in the onset of melanocyte differentiation between fish and mouse, and developmental delay of melanoblast development in zebrafish removes this heterochronic difference. ..