Gene Symbol: kita
Description: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
Alias: c-kit, kit, receptor, sparse, mast/stem cell growth factor receptor kita, SCFR, c-kit homolog, kit receptor a, proto-oncogene tyrosine-protein kinase Kit, spa, spa-1, tyrosine kinase, tyrosine-protein kinase Kit
Species: zebrafish
Products:     kita

Top Publications

  1. Cooper C, Linbo T, Raible D. Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish. Dev Dyn. 2009;238:875-86 pubmed publisher
    We have investigated the role of foxd3 activity in conjunction with signaling by the kit tyrosine kinase receptor in zebrafish black pigment cell (melanophore) development...
  2. Lister J, Robertson C, Lepage T, Johnson S, Raible D. nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. Development. 1999;126:3757-67 pubmed
  3. Kelsh R, Brand M, Jiang Y, Heisenberg C, Lin S, Haffter P, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-89 pubmed
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  4. O Brien E, d Alençon C, Bonde G, Li W, Schoenebeck J, Allende M, et al. Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Dev Biol. 2004;265:246-61 pubmed
    ..Expression of c-kit, which encodes the receptor for the Steel ligand, is reduced in these embryos, and, similar to zebrafish c-kit mutant embryos, embryonic ..
  5. Braasch I, Salzburger W, Meyer A. Asymmetric evolution in two fish-specifically duplicated receptor tyrosine kinase paralogons involved in teleost coloration. Mol Biol Evol. 2006;23:1192-202 pubmed publisher
    ..Here we investigate the evolutionary fate of one of these genes, the type III receptor tyrosine kinase (RTK) colony-stimulating factor 1 receptor (csf1r)...
  6. Parichy D, Ransom D, Paw B, Zon L, Johnson S. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development. 2000;127:3031-44 pubmed
    ..We find that panther corresponds to an orthologue of the c-fms gene, which encodes a type III receptor tyrosine kinase and is the closest known homologue of the previously identified pigment pattern gene, kit...
  7. Engeszer R, Wang G, Ryan M, Parichy D. Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proc Natl Acad Sci U S A. 2008;105:929-33 pubmed publisher
  8. Yao K, Ge W. Kit system in the zebrafish ovary: evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligand (kitlga and kitlgb) during folliculogenesis. Biol Reprod. 2010;82:1216-26 pubmed publisher
    The Kit system, including Kit ligand and its receptor Kit, has critical roles in mammalian reproduction, especially in the ovary...
  9. Knight R, Nair S, Nelson S, Afshar A, Javidan Y, Geisler R, et al. lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development. 2003;130:5755-68 pubmed
    ..These studies demonstrate that low is required for early steps in neural crest development and suggest that tfap2a is essential for the survival of a subset of neural crest derivatives. ..

More Information


  1. Knight R, Javidan Y, Nelson S, Zhang T, Schilling T. Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Dev Dyn. 2004;229:87-98 pubmed
    ..Early melanophores do not develop in low mutants, and we propose that this results in part from a loss of kit function, leading to defects in migration, as well as kit-independent defects in melanophore specification...
  2. Hultman K, Bahary N, Zon L, Johnson S. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet. 2007;3:e17 pubmed the middle of each somite during stages of melanocyte migration and later expressed in the skin, when the receptor is required for melanocyte survival...
  3. Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P. Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol. 2010;8:e1000562 pubmed publisher
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds. ..
  4. Parichy D, Rawls J, Pratt S, Whitfield T, Johnson S. Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development. 1999;126:3425-36 pubmed
    The relative roles of the Kit receptor in promoting the migration and survival of amniote melanocytes are unresolved. We show that, in the zebrafish, Danio rerio, the pigment pattern mutation sparse corresponds to an orthologue of c-kit...
  5. Mills M, Nuckels R, Parichy D. Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development. 2007;134:1081-90 pubmed
    ..EM melanophores require the kit receptor tyrosine kinase, as kit mutants lack these cells but retain LM melanophores, which form a residual stripe pattern...
  6. Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A, Köster R, et al. Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS ONE. 2010;5:e15170 pubmed publisher
    ..Gal4-UAS system, we have developed a zebrafish transgenic line that expresses oncogenic HRAS under the kita promoter...
  7. Mellgren E, Johnson S. kitb, a second zebrafish ortholog of mouse Kit. Dev Genes Evol. 2005;215:470-77 pubmed
    ..this notion by identification and analysis of a second zebrafish ortholog of the mammalian Kit receptor tyrosine kinase (kitb)...
  8. Mellgren E, Johnson S. A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay. Dev Genes Evol. 2004;214:493-502 pubmed
    ..of differences in gene requirements between zebrafish and mammals is the requirement of the kit receptor tyrosine kinase in melanocyte development...
  9. Rawls J, Johnson S. Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. Dev Biol. 2003;262:152-61 pubmed
    The Kit receptor tyrosine kinase is required by vertebrate melanocytes for their migration and survival. The relationship between these developmental roles of Kit, however, remains poorly understood...
  10. Yao K, Ge W. Spatial distribution and receptor specificity of zebrafish Kit system--evidence for a Kit-mediated bi-directional communication system in the preovulatory ovarian follicle. PLoS ONE. 2013;8:e56192 pubmed publisher
    Consisting of Kit ligand and receptor Kit, the Kit system is involved in regulating many ovarian functions such as follicle activation, granulosa cell proliferation, and oocyte growth and maturation...
  11. Siegel N, Hoegg S, Salzburger W, Braasch I, Meyer A. Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications. BMC Genomics. 2007;8:312 pubmed
  12. Williams H, Brenner S, Venkatesh B. Identification and analysis of additional copies of the platelet-derived growth factor receptor and colony stimulating factor 1 receptor genes in fugu. Gene. 2002;295:255-64 pubmed
    ..receptors for the platelet-derived growth factor (PDGFRalpha and PDGFRbeta) belong to a subfamily of protein tyrosine kinase receptors that also includes kit and the colony stimulating factor-1 receptor (CSF1R)...
  13. Feng Y, RENSHAW S, Martin P. Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE?. Curr Biol. 2012;22:1253-9 pubmed publisher
    ..Our in vivo observations at these early stages of cancer initiation provide a potential mechanistic explanation for why long-term use of low doses of NSAIDs, including aspirin, might reduce cancer onset. ..
  14. Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, et al. Mutations affecting pigmentation and shape of the adult zebrafish. Dev Genes Evol. 1996;206:260-76 pubmed publisher
    ..Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish. ..
  15. Kuroyanagi J, Shimada Y, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, et al. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS Lett. 2014;588:3409-16 pubmed publisher
    Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein...
  16. Van Otterloo E, Li W, Bonde G, Day K, Hsu M, Cornell R. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet. 2010;6:e1001122 pubmed publisher
    ..TFAP2A) contributes to melanocyte development by activating expression of the gene encoding the receptor tyrosine kinase Kit...
  17. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis. ..
  18. Hauptmann G, Gerster T. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Dev Dyn. 2000;218:345-58 pubmed
    ..We propose that coordinate expression of particular combinations of class III POU genes contribute to pattern formation or cell fate determination in the developing CNS and other structures. ..
  19. Lister J, Cooper C, Nguyen K, Modrell M, Grant K, Raible D. Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol. 2006;290:92-104 pubmed
  20. Yang C, Johnson S. Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes. Development. 2006;133:3563-73 pubmed
    ..We further show that larval melanocyte regeneration requires the kit receptor tyrosine kinase. Our results suggest that a small number of melanocyte precursors or stem cells unevenly distributed in ..
  21. Ignatius M, Moose H, El Hodiri H, Henion P. colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis. Dev Biol. 2008;313:568-83 pubmed
  22. Arduini B, Henion P. Melanophore sublineage-specific requirement for zebrafish touchtone during neural crest development. Mech Dev. 2004;121:1353-64 pubmed
    ..Further, our results suggest that, like other neural crest-derived sublineages, melanogenic precursors constitute a heterogeneous population with respect to genetic requirements for development...
  23. Lee Y, Nachtrab G, Klinsawat P, Hami D, Poss K. Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Dis Model Mech. 2010;3:496-503 pubmed publisher active Ras stimulated the in situ amplification of undifferentiated melanocyte precursors expressing mitfa and kita. Active Ras also hyperpigmented early fin regenerates of kita mutants, which are normally devoid of primary ..
  24. Rich A, Gordon S, Brown C, Gibbons S, Schaefer K, Hennig G, et al. Kit signaling is required for development of coordinated motility patterns in zebrafish gastrointestinal tract. Zebrafish. 2013;10:154-60 pubmed publisher
    ..Disruptions of Kit signaling using the Kit antagonist imatinib mesylate, and in Sparse, a null kita mutant, also disrupted development of coordinated motility patterns...
  25. Verduci L, Loparco G, Pozzoli O, Pompilio G, Capogrossi M. Identification of Kita (c-Kit) positive cells in the heart of adult zebrafish. Int J Cardiol. 2014;175:204-5 pubmed publisher
  26. Lang M, Patterson L, Gordon T, Johnson S, Parichy D. Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genet. 2009;5:e1000744 pubmed publisher
    ..a requirement of fin chromatophores for bnc2 is revealed in the absence of kit and colony stimulating factor-1 receptor activity...
  27. Rich A, Leddon S, Hess S, Gibbons S, Miller S, Xu X, et al. Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Dev Dyn. 2007;236:903-11 pubmed
    ..The Sparse mutant, a kita null mutant, showed reduced contraction frequency and increased size of the GI tract indicating a ..
  28. O Reilly Pol T, Johnson S. Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos. Development. 2013;140:996-1002 pubmed publisher
    ..We show that the regeneration defect in kita mutants is not due to defects in MSC recruitment or in the proliferation, differentiation or survival of the ..
  29. Staudt N, Müller Sienerth N, Fane Dremucheva A, Yusaf S, Millrine D, Wright G. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Biochem Biophys Res Commun. 2015;456:527-33 pubmed publisher
    ..The antibodies and the approaches described here will help to address the lack of well-defined antibody reagents in zebrafish research. ..
  30. Montero Balaguer M, Lang M, Sachdev S, Knappmeyer C, Stewart R, De La Guardia A, et al. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Dev Dyn. 2006;235:3199-212 pubmed
    ..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors. ..
  31. Gill J, Lowe L, Nguyen J, Liu P, Blake T, Venkatesh B, et al. Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish. Zebrafish. 2010;7:333-41 pubmed publisher
    ..We have used the pufferfish (fugu) lymphocyte-specific protein tyrosine kinase (flck) promoter, which has been shown to enforce high-level expression in the testes of transgenic mice, to ..
  32. Dooley C, Mongera A, Walderich B, NUSSLEIN VOLHARD C. On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development. 2013;140:1003-13 pubmed publisher
    ..We show that the sparse like (slk) mutant lacks larval and metamorphic melanophores and identify kit ligand a (kitlga) as the underlying ..
  33. Clancey L, Beirl A, Linbo T, Cooper C. Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. PLoS ONE. 2013;8:e65096 pubmed publisher
    ..Taken together, these data suggest that vps11 promotes normal melanophore morphology and survival by inhibiting cathepsin release and/or activity. ..
  34. Barrallo Gimeno A, Holzschuh J, Driever W, Knapik E. Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development. 2004;131:1463-77 pubmed
  35. Halloran M, Berndt J. Current progress in neural crest cell motility and migration and future prospects for the zebrafish model system. Dev Dyn. 2003;228:497-513 pubmed
    ..The zebrafish is particularly well suited for the study of neural crest motility because of the ability to combine genetic manipulation with live imaging of migrating NCCs. ..
  36. de Preux Charles A, Bise T, Baier F, Marro J, Jazwinska A. Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart. Open Biol. 2016;6: pubmed publisher
    ..Taken together, our results show that, while the immune response is not necessary to induce cell-cycle activity in intact preconditioned hearts, inflammation is required for the regeneration of injured hearts in zebrafish. ..
  37. Cernaro V, Sfacteria A, Rifici C, Macrì F, Maricchiolo G, Lacquaniti A, et al. Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression. J Nephrol. 2017;30:385-391 pubmed publisher
    ..In order to analyze the renoprotective activity of erythropoietin, the expression of c-kit and β-catenin was evaluated by immunohistochemistry...