Gene Symbol: kiss1
Description: KiSS-1 metastasis suppressor
Alias: KiSS-1 metastasis suppressor, kisspeptin 1
Species: zebrafish

Top Publications

  1. van Aerle R, Kille P, Lange A, Tyler C. Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish. Peptides. 2008;29:57-64 pubmed
    In mammals, the Kiss1 receptor (Kiss1r) and its kisspeptin ligands are key factors regulating the onset of puberty...
  2. Biran J, Ben Dor S, Levavi Sivan B. Molecular identification and functional characterization of the kisspeptin/kisspeptin receptor system in lower vertebrates. Biol Reprod. 2008;79:776-86 pubmed publisher
    The KISS1 gene encodes the kisspeptin neuropeptide, which activates the KISS1 receptor (KISS1R; G protein-coupled receptor 54; GPR54) and participates in neuroendocrine regulation of GnRH secretion...
  3. Kitahashi T, Ogawa S, Parhar I. Cloning and expression of kiss2 in the zebrafish and medaka. Endocrinology. 2009;150:821-31 pubmed publisher
    Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH...
  4. Servili A, Le Page Y, Leprince J, Caraty A, Escobar S, Parhar I, et al. Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish. Endocrinology. 2011;152:1527-40 pubmed publisher
    ..In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r...
  5. Ogawa S, Ramadasan P, Goschorska M, Anantharajah A, Ng K, Parhar I. Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish. J Comp Neurol. 2012;520:2991-3012 pubmed publisher
    ..We have recently identified two kisspeptin-encoding genes, kiss1 and kiss2, in teleosts...
  6. Ogawa S, Ng K, Ramadasan P, Nathan F, Parhar I. Habenular Kiss1 neurons modulate the serotonergic system in the brain of zebrafish. Endocrinology. 2012;153:2398-407 pubmed publisher
    The Kiss1/KISS1 gene has recently been implicated as a potent hypothalamic regulator of reproductive functions, in particular, the onset of puberty in mammals...
  7. Liu Y, Tang H, Xie R, Li S, Liu X, Lin H, et al. Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish. Endocrinology. 2017;158:604-611 pubmed publisher
  8. Nocillado J, Mechaly A, Elizur A. In silico analysis of the regulatory region of the Yellowtail Kingfish and Zebrafish Kiss and Kiss receptor genes. Fish Physiol Biochem. 2013;39:59-63 pubmed publisher
    ..We obtained in silico 1.5 kb of the zebrafish (Danio rerio) Kiss1, Kiss2, Kiss1r and zfKiss2r sequences upstream of the putative transcriptional ..
  9. Zmora N, Stubblefield J, Golan M, Servili A, Levavi Sivan B, Zohar Y. The medio-basal hypothalamus as a dynamic and plastic reproduction-related kisspeptin-gnrh-pituitary center in fish. Endocrinology. 2014;155:1874-86 pubmed publisher
    ..Kiss2 inhibited, but Kiss1 stimulated, FSh? expression and gonadal development, although hypophysiotropic gnrh1 and gnrh receptor expression ..

More Information


  1. Chen W, Lau S, Fan Y, Wu R, Ge W. Juvenile exposure to bisphenol A promotes ovarian differentiation but suppresses its growth - Potential involvement of pituitary follicle-stimulating hormone. Aquat Toxicol. 2017;193:111-121 pubmed publisher
    ..These effects did not seem to involve the hypothalamus because neither BPA nor E2 altered the expression of kiss1, kiss2, gnrh2 and gnrh3 in the hypothalamus. At the ovary level, BPA and E2 both decreased lhcgr expression...
  2. Yumnamcha T, Khan Z, Rajiv C, Devi S, Mondal G, Sanjita Devi H, et al. Interaction of melatonin and gonadotropin-inhibitory hormone on the zebrafish brain-pituitary-reproductive axis. Mol Reprod Dev. 2017;84:389-400 pubmed publisher
    ..kiss2, another neuropeptide, was high in LL, but kiss1 remain unchanged among the conditions...
  3. Cui Y, Lv S, Liu J, Nie S, Chen J, Dong Q, et al. Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Hum Exp Toxicol. 2017;36:207-217 pubmed publisher
    ..The results indicated that lepa (leptin ?), kiss1 (kisspeptins), xdh (xanthine dehydrogenases), and insr (insulin receptor) were significantly upregulated in F1 ..
  4. Guillot R, Cortés R, Navarro S, Mischitelli M, García Herranz V, Sánchez E, et al. Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Horm Behav. 2016;82:87-100 pubmed publisher
    ..The information provided herein will help to elucidate new central systems involved in control of obesity and should be of invaluable use for sustaining fish production systems. ..
  5. Parhar I, Ogawa S, Ubuka T. Reproductive Neuroendocrine Pathways of Social Behavior. Front Endocrinol (Lausanne). 2016;7:28 pubmed publisher
    ..Recently, it was shown that Kiss1, one of the paralogs of kisspeptin peptide family, regulates fear responses in zebrafish and GnIH inhibits ..
  6. Khor Y, Soga T, Parhar I. Early-life stress changes expression of GnRH and kisspeptin genes and DNA methylation of GnRH3 promoter in the adult zebrafish brain. Gen Comp Endocrinol. 2016;227:84-93 pubmed publisher
    ..The level of GnRH2, GnRH3, Kiss1 and Kiss2 mRNAs were measured between different doses of DEX treatment groups in adult zebrafish...
  7. Tang H, Liu Y, Luo D, Ogawa S, Yin Y, Li S, et al. The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies. Endocrinology. 2015;156:589-99 pubmed publisher
    The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates...
  8. Beretta C, Dross N, Bankhead P, Carl M. The ventral habenulae of zebrafish develop in prosomere 2 dependent on Tcf7l2 function. Neural Dev. 2013;8:19 pubmed publisher
    ..Thus, our finding may provide a simple explanation as to why only neuronal populations of the dorsal habenulae differ in size across brain hemispheres. ..
  9. Shahjahan M, Kitahashi T, Ogawa S, Parhar I. Temperature differentially regulates the two kisspeptin systems in the brain of zebrafish. Gen Comp Endocrinol. 2013;193:79-85 pubmed publisher
    Kisspeptins encoded by the kiss1 and kiss2 genes play an important role in reproduction through the stimulation of gonadotropin-releasing hormone (GnRH) secretion by activating their receptors (KissR1 EU047918 and KissR2 EU047917)...
  10. Zhao Y, Lin M, Mock A, Yang M, Wayne N. Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). PLoS ONE. 2014;9:e104330 pubmed publisher
    Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals...
  11. Song Y, Duan X, Chen J, Huang W, Zhu Z, Hu W. The distribution of kisspeptin (Kiss)1- and Kiss2-positive neurones and their connections with gonadotrophin-releasing hormone-3 neurones in the zebrafish brain. J Neuroendocrinol. 2015;27:198-211 pubmed publisher
    ..We have used transgenics to labell kisspeptin neurones (Kiss1 and Kiss2) with mCherry in zebrafish (Danio rerio)...
  12. Nathan F, Ogawa S, Parhar I. Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT1A and 5-HT2) in zebrafish. J Neurochem. 2015;133:870-8 pubmed publisher
    b>Kiss1, a neuropeptide predominantly expressed in the habenula, modulates the serotonin (5-HT) system to decrease odorant cue [alarm substance (AS)]-evoked fear behaviour in the zebrafish...
  13. Qiu W, Zhao Y, Yang M, Farajzadeh M, Pan C, Wayne N. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. Endocrinology. 2016;157:636-47 pubmed publisher
    ..of GnRH3 neurons in both terminal nerve and hypothalamus, increased expression of reproduction-related genes (kiss1, kiss1r, gnrh3, lhβ, fshβ, and erα), and a marker for synaptic transmission (sv2)...
  14. Kim D, Yun S, Son G, Hwang J, Park C, Kim J, et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology. 2014;155:1864-73 pubmed publisher
    ..This study demonstrates the advantage of evolutionary genomics to explore the evolutionary relationship of a peptide gene family that arose before 2R by local duplications. ..
  15. Beretta C, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez Triana J, et al. Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Curr Biol. 2017;27:270-278 pubmed publisher
    ..This mechanism of network formation may well apply to other circuits, and has only remained undiscovered due to technical limitations. ..
  16. Carnevali O, Gioacchini G, Maradonna F, Olivotto I, Migliarini B. Melatonin induces follicle maturation in Danio rerio. PLoS ONE. 2011;6:e19978 pubmed publisher
    ..These data highlight the effects of melatonin in promoting zebrafish reproduction exerting its effects either in the brain-pituitary and in the gonads. ..
  17. Gioacchini G, Maradonna F, Lombardo F, Bizzaro D, Olivotto I, Carnevali O. Increase of fecundity by probiotic administration in zebrafish (Danio rerio). Reproduction. 2010;140:953-9 pubmed publisher
    ..days of probiotic treatment modulate the gene expression of neuropeptide hormones and metabolic signals, such as kiss1, kiss2 and leptin both at the CNS level and at the peripheral level...
  18. Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena Sempere M, et al. Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals. Mol Cell Endocrinol. 2009;312:61-71 pubmed publisher
  19. Ogawa S, Nathan F, Parhar I. Habenular kisspeptin modulates fear in the zebrafish. Proc Natl Acad Sci U S A. 2014;111:3841-6 pubmed publisher
    Kisspeptin, a neuropeptide encoded by the KISS1/Kiss1, and its cognate G protein-coupled receptor, GPR54 (kisspeptin receptor, Kiss-R), are critical for the control of reproduction in vertebrates...
  20. Lupton C, Sengupta M, Cheng R, Chia J, Thirumalai V, Jesuthasan S. Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish. Eneuro. 2017;4: pubmed publisher
    ..i>Kiss1 mutants were generated with CRISPR/Cas9 using guide RNAs targeted to the signal sequence...