Gene Symbol: kif7
Description: kinesin family member 7
Alias: cos2, costal2, kinesin-like protein kif7, kinesin-like protein costal2
Tay S, Ingham P, Roy S. A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development. 2005;132:625-34 pubmed
..The one striking exception to this rule is the kinesin-like protein Costal2, which plays a central role in controlling the activity of the zinc-finger-containing transcriptional regulator, ..
Wilson C, Nguyen C, Chen M, Yang J, Gacayan R, Huang J, et al
. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009;459:98-102 pubmed publisher
..signalling complex that includes the putative serine-threonine kinase Fused (Fu) and the kinesin Costal 2 (Cos2, also known as Cos), yet Fu does not have a conserved role in Hh signalling in mammals...
Ben J, Elworthy S, Ng A, van Eeden F, Ingham P. Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development. 2011;138:4969-78 pubmed publisher
..Our findings underline the importance of the primary cilium for Hh signaling in zebrafish and reveal the conservation of Ta3 function during vertebrate evolution...
Maurya A, Ben J, Zhao Z, Lee R, Niah W, Ng A, et al
. Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genet. 2013;9:e1003955 pubmed publisher
Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expression of Hh target genes...
Liu Y, Couzens A, Deshwar A, B McBroom Cerajewski L, Zhang X, Puviindran V, et al
. The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci Signal. 2014;7:ra117 pubmed publisher
..Genetic analysis indicates that the kinesin protein Kif7 both promotes and inhibits mouse Hh signaling...
Tessadori F, NoÃ«l E, Rens E, Magliozzi R, Evers van Gogh I, Guardavaccaro D, et al
. Nodal signaling range is regulated by proprotein convertase-mediated maturation. Dev Cell. 2015;32:631-9 pubmed publisher
..Combined in silico and in vivo approaches support a model in which FurinA controls the signaling range of Spaw by cleaving its proprotein into a mature, extracellular form, consequently regulating left-right patterning. ..
Liu C, Song G, Mao L, Long Y, Li Q, Cui Z. Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PLoS ONE. 2015;10:e0139612 pubmed publisher
..Thus, the pTME vector can be used as an alternative tool for both enhancer trapping and mutagenesis across a target genome. ..
Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
..Additionally, we use CRISPRs to generate cos2/kif7mw406, a mutation in the kinesin-4 family member cos2/kif7 that has been implicated in controlling ..