Gene Symbol: keap1b
Description: kelch-like ECH-associated protein 1b
Alias: zgc:171654, kelch-like ECH-associated protein 1, klhl19
Zhao X, Lorent K, Wilkins B, Marchione D, Gillespie K, Waisbourd Zinman O, et al
. Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology. 2016;64:894-907 pubmed publisher
..Insufficient antioxidant capacity of EHCs may be critical to early pathogenesis of human BA. (Hepatology 2016;64:894-907). ..
Li L, Kobayashi M, Kaneko H, Nakajima Takagi Y, Nakayama Y, Yamamoto M. Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish. J Biol Chem. 2008;283:3248-55 pubmed
..We found that fish have two types of Keap1, Keap1a and Keap1b. To our surprise, Keap1a and Keap1b contain the cysteine residue corresponding to Cys-288 and Cys-273, ..
Kobayashi M, Li L, Iwamoto N, Nakajima Takagi Y, Kaneko H, Nakayama Y, et al
. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol. 2009;29:493-502 pubmed publisher
..These results led us to categorize Nrf2 activators into six classes and hypothesize that multiple sensing allows enhanced plasticity in the system. ..
Lin C, Taggart A, Lim K, Cygan K, Ferraris L, Creton R, et al
. RNA structure replaces the need for U2AF2 in splicing. Genome Res. 2016;26:12-23 pubmed publisher
..While largely lost from land dwelling vertebrates, this class of introns is found in 10% of all zebrafish genes. ..
Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
..The corresponding changes in the mRNA levels of Kelch-like-ECH-associated protein 1 (Keap1a and Keap1b) and the inhibitor of ?B? (I?B?a and I?B?b) may contribute to regulate the transcriptional activity of Nrf2 and NF-..
Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..