kctd8

Summary

Gene Symbol: kctd8
Description: potassium channel tetramerization domain containing 8
Alias: dex, BTB/POZ domain-containing protein KCTD8, dexter, potassium channel tetramerisation domain containing 8
Species: zebrafish

Top Publications

  1. Carl M, Bianco I, Bajoghli B, Aghaallaei N, Czerny T, Wilson S. Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron. 2007;55:393-405 pubmed
    ..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries. ..
  2. Gamse J, Kuan Y, Macurak M, Brösamle C, Thisse B, Thisse C, et al. Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development. 2005;132:4869-81 pubmed
    ..The results demonstrate that laterality of the dorsal forebrain influences the formation of midbrain connections and their molecular properties. ..
  3. Bianco I, Carl M, Russell C, Clarke J, Wilson S. Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. 2008;3:9 pubmed publisher
    ..Although signaling from the parapineal is essential for the development of normal lateralization, additional factors clearly act during development to confer left-right identity upon neurons in this highly conserved circuit. ..
  4. Garric L, Ronsin B, Roussigne M, Booton S, Gamse J, Dufourcq P, et al. Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development. 2014;141:1572-9 pubmed publisher
    ..We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry. ..
  5. Snelson C, Santhakumar K, Halpern M, Gamse J. Tbx2b is required for the development of the parapineal organ. Development. 2008;135:1693-702 pubmed publisher
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. ..
  6. Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, et al. The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain. Nat Commun. 2015;6:6686 pubmed publisher
    ..These data support an ancient origin of epithalamic asymmetry, and suggest that a nodal-dependent asymmetry programme operated in the forebrain of ancestral vertebrates before evolving into a variable trait in bony fish. ..
  7. Doll C, Burkart J, Hope K, Halpern M, Gamse J. Subnuclear development of the zebrafish habenular nuclei requires ER translocon function. Dev Biol. 2011;360:44-57 pubmed publisher
    ..Our results show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventricular region and differentiate, resulting in formation of bilaterally symmetric habenular nuclei. ..
  8. deCarvalho T, Subedi A, Rock J, Harfe B, Thisse C, Thisse B, et al. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014;52:636-55 pubmed publisher
    ..Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions. ..
  9. Hüsken U, Stickney H, Gestri G, Bianco I, Faro A, Young R, et al. Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons. Curr Biol. 2014;24:2217-27 pubmed publisher
    ..Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries. ..

More Information

Publications10

  1. Beretta C, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez Triana J, et al. Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Curr Biol. 2017;27:270-278 pubmed publisher
    ..This mechanism of network formation may well apply to other circuits, and has only remained undiscovered due to technical limitations. ..