kctd12.2

Summary

Gene Symbol: kctd12.2
Description: potassium channel tetramerisation domain containing 12.2
Alias: ron, potassium channel tetramerisation domain containing 12.2, right on, righton
Species: zebrafish
Products:     kctd12.2

Top Publications

  1. Aizawa H, Goto M, Sato T, Okamoto H. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Dev Cell. 2007;12:87-98 pubmed
    ..Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei. ..
  2. Kuan Y, Yu H, Moens C, Halpern M. Neuropilin asymmetry mediates a left-right difference in habenular connectivity. Development. 2007;134:857-65 pubmed
    ..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side. ..
  3. Doll C, Burkart J, Hope K, Halpern M, Gamse J. Subnuclear development of the zebrafish habenular nuclei requires ER translocon function. Dev Biol. 2011;360:44-57 pubmed publisher
    ..Our results show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventricular region and differentiate, resulting in formation of bilaterally symmetric habenular nuclei. ..
  4. Bianco I, Carl M, Russell C, Clarke J, Wilson S. Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. 2008;3:9 pubmed publisher
    ..Although signaling from the parapineal is essential for the development of normal lateralization, additional factors clearly act during development to confer left-right identity upon neurons in this highly conserved circuit. ..
  5. Garric L, Ronsin B, Roussigne M, Booton S, Gamse J, Dufourcq P, et al. Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development. 2014;141:1572-9 pubmed publisher
    ..We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry. ..
  6. Taylor R, Qi J, Talaga A, Ma T, Pan L, Bartholomew C, et al. Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation. J Neurosci. 2011;31:9869-78 pubmed publisher
    ..This work describes a regulatory mechanism for neuronal process extension that may be conserved in other developmental contexts in addition to the epithalamus. ..
  7. Gamse J, Kuan Y, Macurak M, Brösamle C, Thisse B, Thisse C, et al. Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development. 2005;132:4869-81 pubmed
    ..The results demonstrate that laterality of the dorsal forebrain influences the formation of midbrain connections and their molecular properties. ..
  8. Ogawa S, Ng K, Ramadasan P, Nathan F, Parhar I. Habenular Kiss1 neurons modulate the serotonergic system in the brain of zebrafish. Endocrinology. 2012;153:2398-407 pubmed publisher
    ..3- and 2.2-fold, P < 0.01). These findings suggest that the autocrine-regulated habenular Kiss1 neurons indirectly regulate the serotonergic system in the raphe nuclei through the IPN in the zebrafish. ..
  9. Lee S, Page McCaw P, Gamse J. Kctd12 and Ulk2 partner to regulate dendritogenesis and behavior in the habenular nuclei. PLoS ONE. 2014;9:e110280 pubmed publisher
    ..Loss of Kctd12 results in increased branching/elaboration and decreased anxiety. We conclude that fine-tuning of habenular dendritogenesis during development is essential for appropriate behavioral responses to negative stimuli. ..

More Information

Publications20

  1. Hüsken U, Stickney H, Gestri G, Bianco I, Faro A, Young R, et al. Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons. Curr Biol. 2014;24:2217-27 pubmed publisher
    ..Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries. ..
  2. Lu P, Lund C, Khuansuwan S, Schumann A, Harney Tolo M, Gamse J, et al. Failure in closure of the anterior neural tube causes left isomerization of the zebrafish epithalamus. Dev Biol. 2013;374:333-44 pubmed publisher
    ..This mechanism fails when the two sides of the epithalamus are widely separated from one another, suggesting that it is dependent upon a signaling protein with limited range. ..
  3. de Borsetti N, Dean B, Bain E, Clanton J, Taylor R, Gamse J. Light and melatonin schedule neuronal differentiation in the habenular nuclei. Dev Biol. 2011;358:251-61 pubmed publisher
    ..We conclude that light and melatonin schedule the differentiation of neurons and the formation of neural processes in the habenular nuclei. ..
  4. Chen Y, Cheng C, Chen G, Hung C, Yang C, Hwang S, et al. Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene. Dev Dyn. 2009;238:746-54 pubmed publisher
    ..Thus, this line can be used to study sncga gene regulation and for left-right asymmetry study in zebrafish brain. ..
  5. deCarvalho T, Subedi A, Rock J, Harfe B, Thisse C, Thisse B, et al. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014;52:636-55 pubmed publisher
    ..Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions. ..
  6. Snelson C, Santhakumar K, Halpern M, Gamse J. Tbx2b is required for the development of the parapineal organ. Development. 2008;135:1693-702 pubmed publisher
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. ..
  7. Kuan Y, Gamse J, Schreiber A, Halpern M. Selective asymmetry in a conserved forebrain to midbrain projection. J Exp Zool B Mol Dev Evol. 2007;308:669-78 pubmed
    ..Thus, although the habenulo-interpeduncular conduction system is highly conserved in the vertebrate brain, the stereotypic dorsoventral topography of left-right connections appears to be a feature that is specific to teleosts. ..
  8. Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, et al. The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain. Nat Commun. 2015;6:6686 pubmed publisher
    ..These data support an ancient origin of epithalamic asymmetry, and suggest that a nodal-dependent asymmetry programme operated in the forebrain of ancestral vertebrates before evolving into a variable trait in bony fish. ..
  9. Khuansuwan S, Clanton J, Dean B, Patton J, Gamse J. A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex. Development. 2016;143:2641-50 pubmed publisher
    ..We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors. ..
  10. Wu S, de Borsetti N, Bain E, Bulow C, Gamse J. Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Dev Biol. 2014;385:13-22 pubmed publisher
    ..We propose that the Mediator complex is responsible for subtle but significant changes in transcriptional timing and amplitude that are essential for coordinating the development of neurons in the epithalamus. ..
  11. Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed publisher
    ..We provide clear evidence in support of dbx1b marking the progenitor populations that give rise to the dorsal habenulae. In addition, the expression of dbx1b in the dorsal diencephalon is tightly controlled by FGF signaling. ..