kctd12.1

Summary

Gene Symbol: kctd12.1
Description: potassium channel tetramerisation domain containing 12.1
Alias: lov, BTB/POZ domain-containing protein KCTD12, leftover
Species: zebrafish
Products:     kctd12.1

Top Publications

  1. deCarvalho T, Akitake C, Thisse C, Thisse B, Halpern M. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Front Neural Circuits. 2013;7:98 pubmed publisher
    ..The results indicate that L-R asymmetry of the epithalamus sets the directionality of olfactory innervation, however, the lhx2a:YFP OB-Ha pathway does not appear to mediate fear responses to aversive odorants...
  2. Roussigné M, Bianco I, Wilson S, Blader P. Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development. 2009;136:1549-57 pubmed publisher
    ..Our results provide evidence of a direct requirement for unilateral Nodal activity in establishing an asymmetry per se, rather than solely in biasing its laterality. ..
  3. Kuan Y, Yu H, Moens C, Halpern M. Neuropilin asymmetry mediates a left-right difference in habenular connectivity. Development. 2007;134:857-65 pubmed
    ..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side. ..
  4. Doll C, Burkart J, Hope K, Halpern M, Gamse J. Subnuclear development of the zebrafish habenular nuclei requires ER translocon function. Dev Biol. 2011;360:44-57 pubmed publisher
    ..Our results show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventricular region and differentiate, resulting in formation of bilaterally symmetric habenular nuclei. ..
  5. Kuan Y, Gamse J, Schreiber A, Halpern M. Selective asymmetry in a conserved forebrain to midbrain projection. J Exp Zool B Mol Dev Evol. 2007;308:669-78 pubmed
    ..Thus, although the habenulo-interpeduncular conduction system is highly conserved in the vertebrate brain, the stereotypic dorsoventral topography of left-right connections appears to be a feature that is specific to teleosts. ..
  6. Carl M, Bianco I, Bajoghli B, Aghaallaei N, Czerny T, Wilson S. Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron. 2007;55:393-405 pubmed
    ..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries. ..
  7. Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, et al. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development. 2013;140:3997-4007 pubmed publisher
    ..Our results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons. ..
  8. Dreosti E, Vendrell Llopis N, Carl M, Yaksi E, Wilson S. Left-right asymmetry is required for the habenulae to respond to both visual and olfactory stimuli. Curr Biol. 2014;24:440-5 pubmed publisher
    ..Our results indicate that loss of brain lateralization has significant consequences upon sensory processing and circuit function. ..
  9. Regan J, Concha M, Roussigne M, Russell C, Wilson S. An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry. Neuron. 2009;61:27-34 pubmed publisher
    ..The combined action of Fgf and Nodal signals ensures the establishment of neuroanatomical asymmetries with consistent laterality. ..

More Information

Publications42

  1. Facchin L, Argenton F, Bisazza A. Lines of Danio rerio selected for opposite behavioural lateralization show differences in anatomical left-right asymmetries. Behav Brain Res. 2009;197:157-65 pubmed publisher
    ..The association between the direction of behavioural selection and pancreas position was less clear-cut, although the concordance between visceral and brain asymmetries exceeded 90% in both strains. ..
  2. Taylor R, Qi J, Talaga A, Ma T, Pan L, Bartholomew C, et al. Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation. J Neurosci. 2011;31:9869-78 pubmed publisher
    ..This work describes a regulatory mechanism for neuronal process extension that may be conserved in other developmental contexts in addition to the epithalamus. ..
  3. Amack J, Wang X, Yost H. Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish. Dev Biol. 2007;310:196-210 pubmed
    ..By targeting morpholinos to DFCs, we show that these cell autonomous functions in KV morphogenesis are necessary for LR patterning throughout the embryo. ..
  4. Aizawa H, Goto M, Sato T, Okamoto H. Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Dev Cell. 2007;12:87-98 pubmed
    ..Genetic hyperactivation and repression of Notch signaling revealed that differential timing determines both specificity and asymmetry in the neurogenesis of neural precursors for the habenular subnuclei. ..
  5. Aizawa H, Bianco I, Hamaoka T, Miyashita T, Uemura O, Concha M, et al. Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus. Curr Biol. 2005;15:238-43 pubmed
  6. de Borsetti N, Dean B, Bain E, Clanton J, Taylor R, Gamse J. Light and melatonin schedule neuronal differentiation in the habenular nuclei. Dev Biol. 2011;358:251-61 pubmed publisher
    ..We conclude that light and melatonin schedule the differentiation of neurons and the formation of neural processes in the habenular nuclei. ..
  7. Snelson C, Santhakumar K, Halpern M, Gamse J. Tbx2b is required for the development of the parapineal organ. Development. 2008;135:1693-702 pubmed publisher
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. ..
  8. Inbal A, Kim S, Shin J, Solnica Krezel L. Six3 represses nodal activity to establish early brain asymmetry in zebrafish. Neuron. 2007;55:407-15 pubmed
    ..Our data reveal a Six3-dependent mechanism for establishment of correct brain laterality and provide an entry point to understanding the genetic regulation of Nodal signaling in the brain. ..
  9. Gamse J, Kuan Y, Macurak M, Brösamle C, Thisse B, Thisse C, et al. Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development. 2005;132:4869-81 pubmed
    ..Three members of the leftover-related KCTD (potassium channel tetramerization domain containing) gene family are expressed differently by the ..
  10. Gamse J, Thisse C, Thisse B, Halpern M. The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development. 2003;130:1059-68 pubmed
    ..The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion. ..
  11. Garric L, Ronsin B, Roussigne M, Booton S, Gamse J, Dufourcq P, et al. Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development. 2014;141:1572-9 pubmed publisher
    ..We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry. ..
  12. Bianco I, Carl M, Russell C, Clarke J, Wilson S. Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev. 2008;3:9 pubmed publisher
    ..Although signaling from the parapineal is essential for the development of normal lateralization, additional factors clearly act during development to confer left-right identity upon neurons in this highly conserved circuit. ..
  13. Noël E, Verhoeven M, Lagendijk A, Tessadori F, Smith K, Choorapoikayil S, et al. A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat Commun. 2013;4:2754 pubmed publisher
    ..We find that Nodal signalling regulates actin gene expression, supporting a model in which Nodal signalling amplifies this tissue-intrinsic mechanism of heart looping. ..
  14. Pavlou S, Astell K, Kasioulis I, Gakovic M, Baldock R, van Heyningen V, et al. Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus. PLoS ONE. 2014;9:e87546 pubmed publisher
    ..Deviations from this strict control result in defects associated with abnormal habenular laterality, which we have documented and quantified in sox2 morphants. ..
  15. Lee S, Page McCaw P, Gamse J. Kctd12 and Ulk2 partner to regulate dendritogenesis and behavior in the habenular nuclei. PLoS ONE. 2014;9:e110280 pubmed publisher
    ..Loss of Kctd12 results in increased branching/elaboration and decreased anxiety. We conclude that fine-tuning of habenular dendritogenesis during development is essential for appropriate behavioral responses to negative stimuli. ..
  16. Beretta C, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez Triana J, et al. Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Curr Biol. 2017;27:270-278 pubmed publisher
    ..This mechanism of network formation may well apply to other circuits, and has only remained undiscovered due to technical limitations. ..
  17. Chandrasekar G, Vesterlund L, Hultenby K, Tapia P ez I, Kere J. The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function. PLoS ONE. 2013;8:e63123 pubmed publisher
    ..Considering all these results, we propose an essential role for dyx1c1 in cilia growth and function...
  18. Ogawa S, Ng K, Ramadasan P, Nathan F, Parhar I. Habenular Kiss1 neurons modulate the serotonergic system in the brain of zebrafish. Endocrinology. 2012;153:2398-407 pubmed publisher
    ..3- and 2.2-fold, P < 0.01). These findings suggest that the autocrine-regulated habenular Kiss1 neurons indirectly regulate the serotonergic system in the raphe nuclei through the IPN in the zebrafish. ..
  19. Serluca F, Xu B, Okabe N, Baker K, Lin S, Sullivan Brown J, et al. Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development. 2009;136:1621-31 pubmed publisher
    ..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes. ..
  20. Schottenfeld J, Sullivan Brown J, Burdine R. Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development. 2007;134:1605-15 pubmed
    ..pkd2 also appears to play a role in the propagation of Nodal signals in the LPM. Based on morpholino studies, we propose an additional role for maternal pkd2 in general mesendoderm patterning. ..
  21. Hu J, Barr M. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Mol Biol Cell. 2005;16:458-69 pubmed
    ..The C. elegans polycystins LOV-1 and PKD-2 are required for male mating behaviors and are localized to sensory cilia...
  22. Lu P, Lund C, Khuansuwan S, Schumann A, Harney Tolo M, Gamse J, et al. Failure in closure of the anterior neural tube causes left isomerization of the zebrafish epithalamus. Dev Biol. 2013;374:333-44 pubmed publisher
    ..This mechanism fails when the two sides of the epithalamus are widely separated from one another, suggesting that it is dependent upon a signaling protein with limited range. ..
  23. Kang N, Ro H, Park Y, Kim H, Huh T, Rhee M. Seson, a novel zinc finger protein, controls cilia integrity for the LR patterning during zebrafish embryogenesis. Biochem Biophys Res Commun. 2010;401:169-74 pubmed publisher
    ..Seson function was also required for ciliogenesis in other tissues such as the pronephros and olfactory organs. Collectively, our data suggest that Seson has critical roles in ciliogenesis and LR body axis patterning. ..
  24. Wu S, de Borsetti N, Bain E, Bulow C, Gamse J. Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Dev Biol. 2014;385:13-22 pubmed publisher
    ..We propose that the Mediator complex is responsible for subtle but significant changes in transcriptional timing and amplitude that are essential for coordinating the development of neurons in the epithalamus. ..
  25. Toyama R, Chen X, Jhawar N, Aamar E, Epstein J, Reany N, et al. Transcriptome analysis of the zebrafish pineal gland. Dev Dyn. 2009;238:1813-26 pubmed publisher
    ..Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development. ..
  26. Chen Y, Cheng C, Chen G, Hung C, Yang C, Hwang S, et al. Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene. Dev Dyn. 2009;238:746-54 pubmed publisher
    ..Thus, this line can be used to study sncga gene regulation and for left-right asymmetry study in zebrafish brain. ..
  27. Snelson C, Burkart J, Gamse J. Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors. Dev Dyn. 2008;237:3538-44 pubmed publisher
    ..Careful analysis shows that flh is not required for tbx2b transcription and double mutants exhibit an additive phenotype. We conclude that Flh and Tbx2b regulate separate programs of pineal and parapineal development. ..
  28. deCarvalho T, Subedi A, Rock J, Harfe B, Thisse C, Thisse B, et al. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014;52:636-55 pubmed publisher
    ..Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions. ..
  29. Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed publisher
    ..We provide clear evidence in support of dbx1b marking the progenitor populations that give rise to the dorsal habenulae. In addition, the expression of dbx1b in the dorsal diencephalon is tightly controlled by FGF signaling. ..
  30. Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, et al. The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain. Nat Commun. 2015;6:6686 pubmed publisher
    ..These data support an ancient origin of epithalamic asymmetry, and suggest that a nodal-dependent asymmetry programme operated in the forebrain of ancestral vertebrates before evolving into a variable trait in bony fish. ..
  31. Noël E, Momenah T, Al Dagriri K, Al Suwaid A, Al Shahrani S, Jiang H, et al. A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function. Hum Mutat. 2016;37:194-200 pubmed publisher
  32. Khuansuwan S, Clanton J, Dean B, Patton J, Gamse J. A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex. Development. 2016;143:2641-50 pubmed publisher
    ..We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors. ..
  33. Domenichini A, Dadda M, Facchin L, Bisazza A, Argenton F. Isolation and genetic characterization of mother-of-snow-white, a maternal effect allele affecting laterality and lateralized behaviors in zebrafish. PLoS ONE. 2011;6:e25972 pubmed publisher
    ..As maternal effect genes are expected to evolve more rapidly when compared to zygotic ones, our results highlight the driving force of maternal effect alleles in the evolution of vertebrates behaviors. ..