kcnk18

Summary

Gene Symbol: kcnk18
Description: potassium channel, subfamily K, member 18
Alias: potassium channel subfamily K member 18, K2P18.1, two-pore-domain potassium channel TRESK
Species: zebrafish

Top Publications

  1. Enyedi P, Czirják G. Molecular background of leak K+ currents: two-pore domain potassium channels. Physiol Rev. 2010;90:559-605 pubmed publisher
    ..In this review, we focus on the physiological roles of K(2P) channels in the most extensively investigated cell types, with special emphasis on the molecular mechanisms of channel regulation. ..
  2. Gierten J, Hassel D, Schweizer P, Becker R, Katus H, Thomas D. Identification and functional characterization of zebrafish K(2P)10.1 (TREK2) two-pore-domain K(+) channels. Biochim Biophys Acta. 2012;1818:33-41 pubmed publisher
    ..1 two-pore-domain K(+) channels that exhibit structural and functional properties largely similar to human K(2P)10.1. We conclude that the zebrafish represents a valid model to study K(2P)10.1 function in vivo. ..
  3. Rahm A, Wiedmann F, Gierten J, Schmidt C, Schweizer P, Becker R, et al. Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:291-300 pubmed publisher
    The human KCNK18 gene is predominantly expressed in brain, spinal cord, and dorsal root ganglion neurons. Encoded K2P18.1K(+) channels are functionally implicated in migraine, pain and anesthesia...