Gene Symbol: kcnj13
Description: potassium inwardly-rectifying channel, subfamily J, member 13
Alias: kir7.1, inward rectifier potassium channel 13, inwardly rectifying potassium channel 7.1, jag, jaguar, obe, obelix
Iwashita M, Watanabe M, Ishii M, Chen T, Johnson S, Kurachi Y, et al
. Pigment pattern in jaguar/obelix zebrafish is caused by a Kir7.1 mutation: implications for the regulation of melanosome movement. PLoS Genet. 2006;2:e197 pubmed
..The zebrafish jaguar/obelix mutant has broader stripes than wild-type fish...
Inaba M, Yamanaka H, Kondo S. Pigment pattern formation by contact-dependent depolarization. Science. 2012;335:677 pubmed publisher
..Cell depolarization and repulsive movement were not observed in pigment cells with the jaguar mutant, which shows defective segregation of melanophores and xanthophores...
Watanabe M, Hiraide K, Okada N. Functional diversification of kir7.1 in cichlids accelerated by gene duplication. Gene. 2007;399:46-52 pubmed publisher
..1, was previously identified as being responsible for the broader stripe zebrafish skin pattern mutant, jaguar/obelix...
Inoue S, Kondo S, Parichy D, Watanabe M. Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. Pigment Cell Melanoma Res. 2014;27:190-200 pubmed
..Our results are the first to identify roles for a tetraspanin superfamily protein in skin pigment pattern formation and suggest new mechanisms for the establishment and maintenance of zebrafish stripe boundaries. ..
Chatterjee A, Lagisz M, Rodger E, Zhen L, Stockwell P, Duncan E, et al
. Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Gene. 2016;590:307-16 pubmed publisher
..Our study provides genome-wide methylome and transcriptome assessment and sheds light on sex-specific epigenetic patterns and in zebrafish for the first time. ..
Henke K, Daane J, Hawkins M, Dooley C, Busch Nentwich E, Stemple D, et al
. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Genetics. 2017;207:609-623 pubmed publisher
..Taken together, these results show that dominant screens are a feasible and productive means to identify mutations that can further our understanding of gene function during postembryonic development and in disease. ..
Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, et al
. Mutations affecting pigmentation and shape of the adult zebrafish. Dev Genes Evol. 1996;206:260-76 pubmed publisher
..The adult pigment pattern was found to be changed by dominant mutations in wanda, asterix, obelix, leopard, salz and pfeffer...
Irion U, FrohnhÃ¶fer H, Krauss J, Ã‡olak Champollion T, Maischein H, Geiger Rudolph S, et al
. Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish. elife. 2014;3:e05125 pubmed publisher
..The phenotypes indicate that these promote homotypic interactions between melanophores and xanthophores, respectively, and those cells instruct the patterning of the iridophores. ..
Frohnhöfer H, Geiger Rudolph S, Pattky M, Meixner M, Huhn C, Maischein H, et al
. Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Biol Open. 2016;5:736-44 pubmed publisher
..8, Cx39.4, and Kir7.1, an inwardly rectifying potassium channel, all known to be regulated by polyamines. Thus, zebrafish provide a vertebrate model to study the in vivo effects of polyamines. ..