Gene Symbol: junbb
Description: JunB proto-oncogene, AP-1 transcription factor subunit b
Alias: junbl, wu:fa95h09, wu:fj44e11, wu:fj68b07, zgc:63933, JunB proto-oncogene, AP-1 transcription factor subunit b, jun B proto-oncogene b, jun B proto-oncogene, like
Species: zebrafish

Top Publications

  1. Ishida T, Nakajima T, Kudo A, Kawakami A. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish. Dev Biol. 2010;340:468-79 pubmed publisher
    ..We previously identified the junb and junb-like (junbl) as transcripts induced in response to tissue injury in zebrafish...
  2. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
  3. Mesquita S, van Drooge B, Oliveira E, Grimalt J, Barata C, Vieira N, et al. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environ Pollut. 2015;206:535-42 pubmed publisher
    ..The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources. ..
  4. Kiesow K, Bennewitz K, Miranda L, Stoll S, Hartenstein B, Angel P, et al. Junb controls lymphatic vascular development in zebrafish via miR-182. Sci Rep. 2015;5:15007 pubmed publisher
    ..In conclusion, our findings uncover with the Junb/miR-182/Foxo1 regulatory axis a novel key player in governing lymphatic vascular morphogenesis in zebrafish. ..
  5. Hale A, den Hertog J. Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration. Mol Cell Biol. 2018;38: pubmed publisher
    ..Expression of mmp9 and junbb, indicative of formation of the wound epidermis and distal blastema, respectively, suggested that these ..
  6. Shen H, Shin E, Lee S, Mathavan S, Koh H, Osato M, et al. Ikk2 regulates cytokinesis during vertebrate development. Sci Rep. 2017;7:8094 pubmed publisher
    ..We further document that reduced phosphorylation of Aurora A by Ikk2 could underlie the basis of these defects in cell division. ..
  7. Nguyen Chi M, Laplace Builhé B, Travnickova J, Luz Crawford P, Tejedor G, Lutfalla G, et al. TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death Dis. 2017;8:e2979 pubmed publisher
    ..Our study reveals that TNFR1 has a necessary and direct role in blastema cell activation suggesting that macrophage subset balance provides the accurate TNF? signal to prime regeneration in zebrafish. ..
  8. Filiano A, Xu Y, Tustison N, Marsh R, Baker W, Smirnov I, et al. Unexpected role of interferon-? in regulating neuronal connectivity and social behaviour. Nature. 2016;535:425-9 pubmed
  9. Chatterjee A, Lagisz M, Rodger E, Zhen L, Stockwell P, Duncan E, et al. Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Gene. 2016;590:307-16 pubmed publisher
    ..Our study provides genome-wide methylome and transcriptome assessment and sheds light on sex-specific epigenetic patterns and in zebrafish for the first time. ..

More Information


  1. Cox J, Zhang B, Pope H, Voigt M. Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS ONE. 2016;11:e0148726 pubmed publisher
    ..We believe this study provides important insight into the mechanisms by which non-myelinating glia react to neuronal death and degeneration in sensory circuits. ..
  2. Yoshinari N, Ishida T, Kudo A, Kawakami A. Gene expression and functional analysis of zebrafish larval fin fold regeneration. Dev Biol. 2009;325:71-81 pubmed publisher
    ..Thus, our results demonstrate that the regeneration model of juvenile zebrafish offers a powerful assay to dissect the regeneration processes. ..
  3. Mathew L, Sengupta S, Kawakami A, Andreasen E, LOHR C, Loynes C, et al. Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem. 2007;282:35202-10 pubmed
    ..These studies also demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern vertebrate regeneration. ..
  4. Fong S, Emelyanov A, Teh C, Korzh V. Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development. 2005;132:3587-96 pubmed
    ..The exclusion of cells lacking T-box proteins in chimeras during development was demonstrated with other T-box genes and may indicate a general functional mechanism for T-box proteins. ..
  5. Yang S, Marín Juez R, Meijer A, Spaink H. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. BMC Genomics. 2015;16:547 pubmed publisher
    ..Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system. ..
  6. Hasegawa T, Nakajima T, Ishida T, Kudo A, Kawakami A. A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration. Dev Biol. 2015;399:80-90 pubmed publisher
    ..We further showed that a diffusible factor in the wild-type body fluid mediates this signal. Thus, our study revealed a novel mechanism that the hematopoietic tissues regulate tissue regeneration through a diffusible signal. ..
  7. Hasegawa T, Hall C, Crosier P, Abe G, Kawakami K, Kudo A, et al. Transient inflammatory response mediated by interleukin-1? is required for proper regeneration in zebrafish fin fold. elife. 2017;6: pubmed publisher
    ..Our study reveals that proper levels of Il1b signaling and tissue inflammation, which are tuned by macrophages, play a crucial role in tissue regeneration. ..
  8. Kenyon A, Gavriouchkina D, Zorman J, Napolitani G, Cerundolo V, Sauka Spengler T. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Sci Rep. 2017;7:6505 pubmed publisher
    ..Further perturbation of the IEGs exposes egr3 as a key transcriptional regulator controlling il1β transcription. ..
  9. Seiler C, Davuluri G, Abrams J, Byfield F, Janmey P, Pack M. Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol. 2012;10:e1001386 pubmed publisher
    ..In addition, they identify an inducible physical signaling pathway sensitive to redox and oncogenic signaling that can drive this process...