Gene Symbol: jak2b
Description: Janus kinase 2b
Alias: JAK2bCA, jak2, tyrosine-protein kinase JAK2, Jak2b kinase, PTK JAK2b, protein tyrosine kinase JAK2b
Figueiredo M, Mareco E, Silva M, Marins L. Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish. Transgenic Res. 2012;21:457-69 pubmed publisher
..Therefore, it seems that hypertrophy and hyperplasia follow two different routes for entire muscle growth, both of them triggered by GHR activation, but regulated by different mechanisms. ..
Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
..This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. ..
Van de Peer Y, Frickey T, Taylor J, Meyer A. Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 2002;295:205-11 pubmed
..When trees are computed by omitting the saturated fraction of sites, most fish duplicates are sister sequences. ..
Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, et al
. In vivo analysis of Ifn-?1 and Ifn-?2 signaling in zebrafish. J Immunol. 2010;185:6774-82 pubmed publisher
..We also show that of the two Jak2 paralogues present in the zebrafish Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-? signal...
O Sullivan L, Noor S, Trengove M, Lewis R, Liongue C, Sprigg N, et al
. Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development. J Immunol. 2011;186:4751-61 pubmed publisher
..These studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2-Stat5 pathway.
Yin J, Shine L, Raycroft F, Deeti S, Reynolds A, Ackerman K, et al
. Inhibition of the Pim1 oncogene results in diminished visual function. PLoS ONE. 2012;7:e52177 pubmed publisher
..In summary, we have identified that enhanced expression of Jak-Stat pathway genes correlates with maturation of visual function and that the Pim1 oncogene is required for normal visual function. ..