jag2b

Summary

Gene Symbol: jag2b
Description: jagged 2b
Alias: jag2, serB, zgc:152855, protein jagged-2, jagged 2, serrateB, unp1068
Species: zebrafish

Top Publications

  1. Lorent K, Yeo S, Oda T, Chandrasekharappa S, Chitnis A, Matthews R, et al. Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development. 2004;131:5753-66 pubmed
    ..These data confirm an evolutionarily conserved role for Notch signaling in vertebrate liver development, and support the zebrafish as a model system for diseases of the human biliary system...
  2. Qiu X, Xu H, Haddon C, Lewis J, Jiang Y. Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe. Dev Dyn. 2004;231:621-30 pubmed
  3. Crosnier C, Vargesson N, Gschmeissner S, Ariza McNaughton L, Morrison A, Lewis J. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development. 2005;132:1093-104 pubmed
    ..These findings demonstrate the central role of Notch signalling in the gut stem-cell system and establish the zebrafish as a model for study of the mechanisms controlling renewal of gut epithelium. ..
  4. Ma M, Jiang Y. Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genet. 2007;3:e18 pubmed
    ..Taken together, our findings add a new paradigm of Notch signaling in kidney development, namely, that Jagged2a-Notch signaling modulates cell fate choice in a nephric segment, the distal pronephric duct. ..
  5. Zecchin E, Conigliaro A, Tiso N, Argenton F, Bortolussi M. Expression analysis of jagged genes in zebrafish embryos. Dev Dyn. 2005;233:638-45 pubmed
    ..The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes. ..
  6. Zecchin E, Filippi A, Biemar F, Tiso N, Pauls S, Ellertsdottir E, et al. Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish. Dev Biol. 2007;301:192-204 pubmed
  7. Liu Y, Pathak N, Kramer Zucker A, Drummond I. Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development. 2007;134:1111-22 pubmed
    ..We find that the Notch ligand Jagged 2 is expressed in MCCs and that notch3 is expressed in pronephric epithelial cells...
  8. Hsiao C, You M, Guh Y, Ma M, Jiang Y, Hwang P. A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytes. PLoS ONE. 2007;2:e302 pubmed
  9. Haddon C, Jiang Y, Smithers L, Lewis J. Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant. Development. 1998;125:4637-44 pubmed
    ..Similar misregulation of delta ; genes is seen in the ear, along with misregulation of a Serrate homologue, serrateB, coding for an alternative Notch ligand...

More Information

Publications37

  1. Janicke M, Carney T, Hammerschmidt M. Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Dev Biol. 2007;307:258-71 pubmed
    ..A model for ionocyte versus keratinocyte development will be presented, postulating additional thus far unidentified pro-ionocyte factors. ..
  2. Chang W, Horng J, Yan J, Hsiao C, Hwang P. The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009;296:R1192-201 pubmed publisher
    ..In conclusion, functional regulation of HR cells is probably achieved by enhancing cell differentiation via zGCM2 activation. ..
  3. Mitsiadis T, Graf D, Luder H, Gridley T, Bluteau G. BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development. 2010;137:3025-35 pubmed publisher
    ..We have analysed the expression, regulation and function of the jagged 2 (Jag2) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth...
  4. Gui J, Greene C, Sullivan C, Taylor W, Moore J, KIM C. Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study. BioData Min. 2015;8:17 pubmed publisher
    ..We compared the mRNA expression for each group and found over 200 differentially expressed genes and several enriched pathways including defense response pathways, arsenic response pathways, and the Notch signaling pathway. ..
  5. Mahler J, Filippi A, Driever W. DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish. J Neurosci. 2010;30:16621-35 pubmed publisher
    ..Rather, DeltaA/D limits the size of the sim1a- and otpa-expressing precursor pool from which dopaminergic neurons differentiate. ..
  6. Packard R, Baek K, Beebe T, Jen N, Ding Y, Shi F, et al. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017;7:8603 pubmed publisher
    ..05, n?=?6-14). Our approach provides a high-throughput model with translational implications for drug discovery and genetic modifiers of chemotherapy-induced cardiomyopathy. ..
  7. Zuniga E, Stellabotte F, Crump J. Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development. 2010;137:1843-52 pubmed publisher
    ..Together, these results indicate a novel function of Jagged-Notch signaling in ensuring dorsal identity within broad fields of facial skeletal precursors. ..
  8. Delfino Machin M, Madelaine R, Busolin G, Nikaido M, Colanesi S, Camargo Sosa K, et al. Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors. PLoS ONE. 2017;12:e0172947 pubmed publisher
    ..Sox10 is thus a key transcription factor in achieving the balance of sensory neuronal and glial fates. ..
  9. Hwang P, Chou M. Zebrafish as an animal model to study ion homeostasis. Pflugers Arch. 2013;465:1233-47 pubmed publisher
  10. Han P, Bloomekatz J, Ren J, Zhang R, Grinstein J, Zhao L, et al. Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 2016;534:700-4 pubmed publisher
  11. Wang X, Wang X, Yuan W, Chai R, Liu D. Egfl6 is involved in zebrafish notochord development. Fish Physiol Biochem. 2015;41:961-9 pubmed publisher
    ..We found that inhibition of Notch signaling by DAPT efficiently rescued notochord developmental defect of Egfl6 deficiency embryos. ..
  12. O Brien L, Grimaldi M, Kostun Z, Wingert R, Selleck R, Davidson A. Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Dev Biol. 2011;358:318-30 pubmed publisher
    ..These findings further our understanding of the transcriptional circuitry responsible for podocyte formation and differentiation during kidney development. ..
  13. Pascoal S, Esteves de Lima J, Leslie J, Hughes S, Saude L. Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish. PLoS ONE. 2013;8:e68021 pubmed publisher
    ..We propose that by controlling the differentiation of myogenic progenitor cells, Notch signalling might secure the formation of structurally stable muscle fibres in the zebrafish pectoral fin. ..
  14. Morris J, Chomyk A, Song P, Parker N, Deckard S, Trapp B, et al. Decrease in levels of the evolutionarily conserved microRNA miR-124 affects oligodendrocyte numbers in Zebrafish, Danio rerio. Invert Neurosci. 2015;15:4 pubmed publisher
    ..Taken together, our results add a new dimension to the existing complexity of neuron-glial relationships and highlight the utility of Danio rerio as a model system to investigate such interactions. ..
  15. Gwak J, Kong H, Bae Y, Kim M, Lee J, Park J, et al. Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b. Mol Cells. 2010;30:155-9 pubmed publisher
  16. Yeo S, Chitnis A. Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord. Proc Natl Acad Sci U S A. 2007;104:5913-8 pubmed
  17. Zhang D, Gates K, Barske L, Wang G, Lancman J, Zeng X, et al. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017;8:769 pubmed publisher
    ..zebrafish embryos with compound homozygous mutations in two Notch ligand genes, jagged1b (jag1b) and jagged2b (jag2b) exhibit a complete loss of canonical Notch activity and duct cells within the liver and exocrine pancreas, ..
  18. Yee N, Lorent K, Pack M. Exocrine pancreas development in zebrafish. Dev Biol. 2005;284:84-101 pubmed
    ..By contrast, analyses of mind bomb mutants and jagged morpholino-injected larvae suggest that Notch signaling principally regulates ductal differentiation of bipotential exocrine progenitors. ..
  19. Romero Carvajal A, Navajas Acedo J, Jiang L, Kozlovskaja GumbrienÄ— A, Alexander R, Li H, et al. Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways. Dev Cell. 2015;34:267-82 pubmed publisher
    ..The striking similarities to other vertebrate stem cell compartments uniquely place zebrafish to help elucidate why mammals possess such low capacity to regenerate hair cells. ..
  20. Tian J, Ling L, Shboul M, Lee H, O CONNOR B, Merriman B, et al. Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. Am J Hum Genet. 2010;87:768-78 pubmed publisher
    ..of CHSY1 by RNAi knockdown resulted in enhanced osteogenesis in fetal osteoblasts and remarkable upregulation of JAG2 in glioblastoma cells...
  21. Wang X, Yuan W, Wang X, Qi J, Qin Y, Shi Y, et al. The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget. 2016;7:77749-77763 pubmed publisher
    ..We conclude that Maeg acts as a positive regulator of angiogenic cell behavior and formation of functional vessels. ..
  22. Alunni A, Krecsmarik M, Bosco A, Galant S, Pan L, Moens C, et al. Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium. Development. 2013;140:3335-47 pubmed publisher
    ..They implicate Notch3 at the top of this hierarchy to gate NSC activation and amplification, protecting the homeostasis of adult NSC reservoirs under physiological conditions. ..
  23. Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, et al. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol. 2010;30:1695-702 pubmed publisher
    ..At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network. ..
  24. Dias T, Yang Y, Ogai K, Becker T, Becker C. Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish. J Neurosci. 2012;32:3245-52 pubmed publisher
    ..This demonstrates that Notch is a negative signal for regenerative neurogenesis, and, importantly, that spinal motor neuron regeneration can be augmented in an adult vertebrate by inhibiting Notch signaling. ..
  25. Krueger J, Liu D, Scholz K, Zimmer A, Shi Y, Klein C, et al. Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development. 2011;138:2111-20 pubmed publisher
    ..Thus, Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching. Flt1 distribution may be fine-tuned, involving interactions with the developing nervous system. ..
  26. Chou C, Lin J, Jiang Y, Liu Y. Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish. Endocrinology. 2017;158:4206-4217 pubmed publisher
  27. Lee J, Fei P, Packard R, Kang H, Xu H, Baek K, et al. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016;126:1679-90 pubmed publisher
    ..Subjecting endothelial cells to pulsatile flow in the presence of the ADAM10 inhibitor corroborated shear stress-activated Notch signaling to modulate trabeculation. ..
  28. Lecaudey V, Ulloa E, Anselme I, Stedman A, Schneider Maunoury S, Pujades C. Role of the hindbrain in patterning the otic vesicle: a study of the zebrafish vhnf1 mutant. Dev Biol. 2007;303:134-43 pubmed
    ..They suggest that, despite the evolution of inner ear structure and function, some of the mechanisms underlying the regionalisation of the otic vesicle in fish and amniotes have been conserved. ..