Gene Symbol: itpr3
Description: inositol 1,4,5-trisphosphate receptor, type 3
Alias: si:dkey-163f12.8, inositol 1,4,5-trisphosphate receptor type 3, inositol 1,4,5-triphosphate receptor, type 3
Ashworth R, Devogelaere B, Fabes J, Tunwell R, Koh K, De Smedt H, et al
. Molecular and functional characterization of inositol trisphosphate receptors during early zebrafish development. J Biol Chem. 2007;282:13984-93 pubmed
..Inhibition of Ca(2+) entry or ryanodine receptors, however, had little effect. Our work defines the importance of IP(3) receptors during early development of a genetically and optically tractable model vertebrate organism. ..
B hne A, Darras A, D Cotta H, Baroiller J, Galiana Arnoux D, Volff J. The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. BMC Genomics. 2010;11:721 pubmed publisher
..Comparative expression analysis strongly suggests that the ancestral E3 ubiquitin ligase function of the single copy mkrn gene before duplication in vertebrates was gonad-specific, with maternal expression in early embryos...
Musso G, Tasan M, Mosimann C, Beaver J, Plovie E, Carr L, et al
. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014;141:224-35 pubmed publisher
..Thus, we show that systematic prioritization in zebrafish can accelerate the pace of developmental gene function discovery. ..
Yartseva V, Takacs C, Vejnar C, Lee M, Giraldez A. RESA identifies mRNA-regulatory sequences at high resolution. Nat Methods. 2017;14:201-207 pubmed publisher
..Finally, we used the versatile RESA platform to map candidate protein-RNA interactions in vivo (RESA-CLIP). ..
Henke K, Daane J, Hawkins M, Dooley C, Busch Nentwich E, Stemple D, et al
. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Genetics. 2017;207:609-623 pubmed publisher
..Taken together, these results show that dominant screens are a feasible and productive means to identify mutations that can further our understanding of gene function during postembryonic development and in disease. ..
Petko J, Kabbani N, Frey C, Woll M, Hickey K, Craig M, et al
. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neurosci. 2009;10:27 pubmed publisher
Paavola J, Schliffke S, Rossetti S, Kuo I, Yuan S, Sun Z, et al
. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J Mol Cell Cardiol. 2013;58:199-208 pubmed publisher
..In human subjects we found an association between ADPKD and IDCM and suggest that PKD mutations contribute to the development of heart failure. ..
Albasanz J, Santana S, Guzman Sanchez F, LeÃ³n D, Burgos J, MartÃn M. 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates Metabotropic Glutamate 5 Receptors Endogenously Expressed in Zebrafish Brain. ACS Chem Neurosci. 2016;7:1690-1697 pubmed publisher
..In addition, our data point to zebrafish as a useful model to study mGlu receptor function in both healthy and pathological conditions. ..