Gene Symbol: itgav
Description: integrin, alpha V
Alias: zgc:136222, integrin alpha-V, vitronectin receptor, alpha
Species: zebrafish
Products:     itgav

Top Publications

  1. Ablooglu A, Kang J, Handin R, Traver D, Shattil S. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007;236:2268-76 pubmed
    ..Furthermore, when beta3.1 expression profiles are compared to those of other potential alphaV partners (beta1, beta5, and beta8), pharyngeal dentitions appear to represent a unique expression field for alphaV and beta3.1. ..
  2. Nikolic I, Stankovic N, Bicker F, Meister J, Braun H, Awwad K, et al. EGFL7 ligates ?v?3 integrin to enhance vessel formation. Blood. 2013;121:3041-50 pubmed publisher
    ..In sum, our work sheds a novel light on the molecular mechanism EGFL7 engages to govern physiological and pathological angiogenesis. ..
  3. Fitzpatrick P, Shattil S, Ablooglu A. C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. J Biol Chem. 2014;289:11183-93 pubmed publisher
    ..Thus, by employing zebrafish as an in situ physiological tool to correlate protein structure and function, we have discovered an unexpected association chemistry between an integrin and a key adapter involved in integrin signaling. ..
  4. Burczyk M, Burkhalter M, Blätte T, Matysik S, Caron M, BARAK L, et al. Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Biochemistry. 2015;54:765-75 pubmed publisher
    ..The ability of reduced GRK2 activity to reverse a developmental phenotype associated with constitutive desensitization supports efforts to genetically or pharmacologically target this kinase in diseases involving biased GPCR signaling. ..
  5. Ablooglu A, Tkachenko E, Kang J, Shattil S. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010;137:3449-58 pubmed publisher
  6. Liu J, Zeng L, Kennedy R, Gruenig N, Childs S. ?Pix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin ?v?8. Dev Biol. 2012;363:95-105 pubmed publisher
    ..These data suggest that a complex involving ?Pix, GIT1 and integrin ?(v)?(8) may regulate vascular stability, cerebral angiogenesis and endothelial cell proliferation in the developing embryo. ..
  7. Go W, Korzh V. Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish. Bone. 2013;54:48-57 pubmed publisher
    ..atp2b1a's expression in the pharyngeal epithelium is regulated by the homeodomain transcription factor dlx2b. ..
  8. Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley S. Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Curr Biol. 2013;23:1335-41 pubmed publisher
    ..Tissue-specific transgenic rescue experiments suggest that the FN matrix on the surface of the paraxial mesoderm is required for body elongation via its role in defining tissue mechanics and intertissue adhesion. ..
  9. Feng G, Long Y, Peng J, Li Q, Cui Z. Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish. BMC Genomics. 2015;16:979 pubmed publisher

More Information


  1. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
    ..We conclude that CERKL deficiency in zebrafish may cause rod-cone dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associated with down-regulation of the expression of MERTK. ..