Gene Symbol: itga5
Description: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Alias: sb:cb665, wu:fe02h07, integrin alpha-5, fibronectin receptor alpha subunit, integrin alpha5, polypterus
Species: zebrafish

Top Publications

  1. Jülich D, Geisler R, Holley S. Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Dev Cell. 2005;8:575-86 pubmed
    ..Our data suggest that notch- and integrinalpha5-dependent cell polarization and Fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis. ..
  2. Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani Seiki M, Kondoh H, et al. Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell. 2005;8:587-98 pubmed
    ..By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes...
  3. Jülich D, Mould A, Koper E, Holley S. Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling. Development. 2009;136:2913-21 pubmed publisher
    ..Within the tissue, interplay between Eph/Ephrin signaling, ligand-independent Integrin clustering and reciprocal Integrin inhibition restricts de novo ECM production to somite boundaries...
  4. Mould A, Koper E, Byron A, Zahn G, Humphries M. Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J. 2009;424:179-89 pubmed publisher
    ..Using a gain-of-function analysis involving swapping regions of the zebrafish integrin alpha5 subunit with the corresponding regions of human alpha5 we show that blades 1-4 of the beta-propeller are ..
  5. Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
    ..levels of genes affecting tumor cell-extracellular matrix interaction, including loxl3, itga2b, itga3, and itga5. Our results provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, ..
  6. McMillen P, Chatti V, Jülich D, Holley S. A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Curr Biol. 2016;26:542-9 pubmed publisher
    ..Throughout somitogenesis, Cdh2 promotes ECM assembly along tissue boundaries and inhibits ECM assembly in the tissue mesenchyme. ..
  7. Subramanian A, Schilling T. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. elife. 2014;3: pubmed publisher
    ..Thus Tsp4 functions as an ECM scaffold at MTJs, with potential therapeutic uses in tendon strengthening and repair. ..
  8. Choi Y, Kim H, Kim J, Kim H, Kang M, Lee M, et al. TM4SF5 suppression disturbs integrin ?5-related signalling and muscle development in zebrafish. Biochem J. 2014;462:89-101 pubmed publisher
    ..Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin ?5-related signalling...
  9. Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley S. Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics. Curr Biol. 2013;23:1335-41 pubmed publisher
    ..Tissue-specific transgenic rescue experiments suggest that the FN matrix on the surface of the paraxial mesoderm is required for body elongation via its role in defining tissue mechanics and intertissue adhesion. ..

More Information


  1. Michaelis U, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, et al. The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res. 2013;112:924-34 pubmed publisher
    ..Scrib is a novel regulator of integrin ?5 turnover and sorting, which is required for oriented cell migration and sprouting angiogenesis. ..
  2. Hayes J, Hartsock A, Clark B, Napier H, Link B, Gross J. Integrin ?5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Mol Biol Cell. 2012;23:4725-38 pubmed publisher
  3. Bhat N, Riley B. Integrin-?5 coordinates assembly of posterior cranial placodes in zebrafish and enhances Fgf-dependent regulation of otic/epibranchial cells. PLoS ONE. 2011;6:e27778 pubmed publisher
    ..We have investigated whether placodal assembly in zebrafish requires Integrin- ?5 (itga5), an extracellular matrix receptor initially expressed throughout the preplacodal ectoderm...
  4. Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
    ..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
  5. Arrington C, Yost H. Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development. 2009;136:3143-52 pubmed publisher
  6. Raeker M, Russell M. Obscurin depletion impairs organization of skeletal muscle in developing zebrafish embryos. J Biomed Biotechnol. 2011;2011:479135 pubmed publisher
  7. Lackner S, Schwendinger Schreck J, Jülich D, Holley S. Segmental assembly of fibronectin matrix requires rap1b and integrin ?5. Dev Dyn. 2013;242:122-31 pubmed publisher
  8. Qiao L, Gao H, Zhang T, Jing L, Xiao C, Xiao Y, et al. Snail modulates the assembly of fibronectin via ?5 integrin for myocardial migration in zebrafish embryos. Sci Rep. 2014;4:4470 pubmed publisher
    ..The results provide the molecular mechanism how Snail controls the morphogenesis of heart during embryonic development. ..
  9. Olesnicky E, Hernandez Lagunas L, Artinger K. prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. Genesis. 2010;48:656-66 pubmed publisher
    ..In addition, we identified a number of other novel downstream targets of Prdm1a that may be important for the development of diverse tissues during zebrafish embryogenesis. ..
  10. McCurley A, Callard G. Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration. J Exp Neurosci. 2010;2010:17-33 pubmed
  11. Lamonica K, Ding H, Artinger K. prdm1a functions upstream of itga5 in zebrafish craniofacial development. Genesis. 2015;53:270-7 pubmed publisher
    ..analysis between wildtype and prdm1a mutants at 25 h post fertilization demonstrated that integrin α5 (itga5) is differentially expressed in prdm1a mutants...
  12. Lui E, Li C, Li Z, Gong Z, Lam S. Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. J Genet Genomics. 2016;43:525-8 pubmed publisher
  13. Crump J, Swartz M, Kimmel C. An integrin-dependent role of pouch endoderm in hyoid cartilage development. PLoS Biol. 2004;2:E244 pubmed
    ..Lastly, we discuss the implications of a mosaic assembly of the facial skeleton for the evolution of ray-finned fish. ..
  14. Chiu C, Chou C, Takada S, Liu Y. Development and fibronectin signaling requirements of the zebrafish interrenal vessel. PLoS ONE. 2012;7:e43040 pubmed publisher
    ..The accumulation of peri-IRV Fn requires Integrin ?5 (Itga5), with its knockdown leading to interrenal and IRV morphologies phenocopying those in the fn1 morphant and mutant...
  15. Karpanen T, Padberg Y, van de Pavert S, Dierkes C, Morooka N, Peterson Maduro J, et al. An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res. 2017;120:1263-1275 pubmed publisher