Gene Symbol: isg15
Description: ISG15 ubiquitin-like modifier
Alias: g1p2, si:rp71-1c23.2, si:rp71-1c23.2, interferon stimulated gene, 15 kDa, interferon, alpha-inducible protein, zfISG15
Species: zebrafish

Top Publications

  1. Chen H, Liu W, Wu S, Chiou P, Li Y, Chen Y, et al. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015;43:427-35 pubmed publisher
    ..Taken together, our results indicate that RIG-I plays an essential role in zebrafish group II type I IFN induction and the inflammatory response to NNV infection. ..
  2. Liu M, Reimschuessel R, Hassel B. Molecular cloning of the fish interferon stimulated gene, 15 kDa (ISG15) orthologue: a ubiquitin-like gene induced by nephrotoxic damage. Gene. 2002;298:129-39 pubmed
    ..Sequence analysis revealed that 40.1 contains tandem UBL domains, and shares homology with ISG15, a 15 kD interferon-(IFN) stimulated UBL found in mammals...
  3. Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
    ..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..
  4. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
    ..In addition, overexpression of IRF6 activated the transcription of isg15, rig-i and mavs of host cells; meanwhile, the transcripts of p, m and n genes of SVCV were significantly declined ..
  5. Longman D, Hug N, Keith M, Anastasaki C, Patton E, Grimes G, et al. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res. 2013;41:8319-31 pubmed publisher
    ..Furthermore, the conservation of a mechanism to tightly control NMD homeostasis across different species highlights the importance of the NMD response in the control of gene expression. ..
  6. Seppola M, Stenvik J, Steiro K, Solstad T, Robertsen B, Jensen I. Sequence and expression analysis of an interferon stimulated gene (ISG15) from Atlantic cod (Gadus morhua L.). Dev Comp Immunol. 2007;31:156-71 pubmed
    ..One of the most abundant genes was ISG15, showing 24-53% amino acid similarity to ISG15 from both mammals and teleosts...
  7. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  8. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
  9. Nie L, Zhang Y, Dong W, Xiang L, Shao J. Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity. Dev Comp Immunol. 2015;48:95-101 pubmed publisher
    ..activated the NF-κB and IFN signaling pathways, leading to the expression of TNF-α, IL-8 and IFN-induced Mx, ISG15, and viperin...

More Information


  1. Langevin C, van der Aa L, Houel A, Torhy C, Briolat V, Lunazzi A, et al. Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response. J Virol. 2013;87:10025-36 pubmed publisher
    b>ISG15, a 15-kDa interferon-induced protein that participates in antiviral defenses of mammals, is highly conserved among vertebrates. In fish, as in mammals, viral infection and interferon treatment induce isg15 expression...
  2. Wong R, Oxendine S, Godwin J. Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment. BMC Genomics. 2013;14:348 pubmed publisher
    ..This study provides data that could help identify common molecular mechanisms of fluoxetine action across animal taxa. ..
  3. Ge R, Zhou Y, Peng R, Wang R, Li M, Zhang Y, et al. Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish. J Virol. 2015;89:7696-706 pubmed publisher
    ..This proof-of-concept study indicates that the zebrafish represents an amenable model for the investigation of cytosolic DNA sensing mechanisms. ..
  4. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  5. Aleksejeva E, Houel A, Briolat V, Levraud J, Langevin C, Boudinot P. Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Dev Comp Immunol. 2016;57:48-56 pubmed publisher
    ..Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms. ..
  6. Zhang Q, Meng F, Chen S, Plouffe S, Wu S, Liu S, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017;19:362-374 pubmed publisher
    ..Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defence. ..
  7. Wang Y, Zhang H, Lu Y, Wang F, Liu L, Liu J, et al. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Fish Shellfish Immunol. 2017;69:35-45 pubmed publisher
    ..The transcriptome analysis results demonstrated changes and tissue-specific influences caused by SVCV in vivo, which provided us with more information to understand the complex relationships between SVCV and its host. ..
  8. Xiong R, Nie L, Xiang L, Shao J. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. J Immunol. 2012;188:2653-68 pubmed publisher
    ..It presents valuable clues for improving the understanding of not only the negative regulation of cytokine signaling in fish but also the evolutionary history of the PIAS family from fish to mammals as a whole. ..