Gene Symbol: irx6a
Description: iroquois homeobox 6a
Alias: zgc:109993, ziro6a, iroquois-class homeodomain protein IRX-6, iroquois homeobox protein 6a
Species: zebrafish

Top Publications

  1. de la Calle Mustienes E, Feijóo C, Manzanares M, Tena J, Rodríguez Seguel E, Letizia A, et al. A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts. Genome Res. 2005;15:1061-72 pubmed
    ..However, inter-species conserved sequences surrounding the core, specific for each of these UCRs, are able to modulate their expression. ..
  2. McDonald L, Gerrelli D, Fok Y, Hurst L, Tickle C. Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos. J Anat. 2010;216:683-91 pubmed publisher
    ..In zebrafish, Irx genes of all but six of the families are expressed in early stage pectoral fin buds but not at later stages, suggesting that these genes are not involved in patterning distal structures in zebrafish fins. ..
  3. Feijóo C, Manzanares M, de la Calle Mustienes E, Gomez Skarmeta J, Allende M. The Irx gene family in zebrafish: genomic structure, evolution and initial characterization of irx5b. Dev Genes Evol. 2004;214:277-84 pubmed
    ..In total there are 11 existing Irx genes in zebrafish and 10 in pufferfish. We propose a new nomenclature for the zebrafish Irx genes based on the analysis of their sequences and their genomic relationships. ..
  4. Lecaudey V, Anselme I, Dildrop R, Ruther U, Schneider Maunoury S. Expression of the zebrafish Iroquois genes during early nervous system formation and patterning. J Comp Neurol. 2005;492:289-302 pubmed
    ..Overall, these expression data suggest functions for the Iroquois family of transcription factors in neural and placodal patterning, neurogenesis, and neuronal specification. ..
  5. Choy S, Cheng C, Lee S, Li V, Hui M, Hui C, et al. A cascade of irx1a and irx2a controls shh expression during retinogenesis. Dev Dyn. 2010;239:3204-14 pubmed publisher
    ..We proposed a novel transcriptional cascade of ath5-irx1a-irx2a in the regulation of hedgehog waves during vertebrate retinal development. ..
  6. Linder B, Dill H, Hirmer A, Brocher J, Lee G, Mathavan S, et al. Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa. Hum Mol Genet. 2011;20:368-77 pubmed publisher
    ..Hence, various routes affecting the tri-snRNP can elicit tissue-specific gene expression defects and lead to the RP phenotype. ..
  7. Tena J, Alonso M, de la Calle Mustienes E, Splinter E, de Laat W, Manzanares M, et al. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat Commun. 2011;2:310 pubmed publisher