irf7

Summary

Gene Symbol: irf7
Description: interferon regulatory factor 7
Alias: wu:fl24c03, zgc:66043, zgc:77947, interferon regulatory factor 7
Species: zebrafish

Top Publications

  1. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
  2. Feng H, Zhang Q, Zhang Y, Li Z, Zhang J, Xiong Y, et al. Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN?1 and IFN?3 Expression through Assembly of Homo- or Heteroprotein Complexes. J Immunol. 2016;197:1893-904 pubmed publisher
    In mammals, IFN regulatory factor (IRF)1, IRF3, and IRF7 are three critical transcription factors that are pivotal for cooperative regulation of the type I IFN response...
  3. Zou P, Chang M, Li Y, Huan Zhang S, Fu J, Chen S, et al. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43:13-24 pubmed publisher
    ..with RIG-Ib or MAVS, induced a significantly higher level of type I IFN promoter activity and the expression level of Mx and IRF7, implying that the RIG-Ia may function as an enhancer in the RIG-Ib/MAVS-mediated signaling pathway.
  4. Cui H, Yan Y, Wei J, Huang X, Huang Y, Ouyang Z, et al. Identification and functional characterization of an interferon regulatory factor 7-like (IRF7-like) gene from orange-spotted grouper, Epinephelus coioides. Dev Comp Immunol. 2011;35:672-84 pubmed publisher
    ..In the present study, a novel IRF7 gene (designated as EcIRF7) was cloned and characterized from orange-spotted grouper, Epinephelus coioides...
  5. Sun F, Zhang Y, Liu T, Shi J, Wang B, Gui J. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol. 2011;187:2531-9 pubmed publisher
    ..is required for the activation of IFN-?, which, in turn, primes the expression of most IFN-? genes by IFN-induced IRF7 through the STAT1 pathway...
  6. Xiang Z, Dong C, Qi L, Chen W, Huang L, Li Z, et al. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Dev Comp Immunol. 2010;34:1263-73 pubmed publisher
    ..The zfIRF7 protein is identified as a member of the IRF7 family, compared to the human IRF7 protein, the amino acid sequence of zfIRF7 only with 29% identity and devoid a ..
  7. Rey S, Moiche V, Boltaña S, Teles M, MacKenzie S. Behavioural fever in zebrafish larvae. Dev Comp Immunol. 2017;67:287-292 pubmed publisher
    ..In parallel we measured the abundance of antiviral transcripts; viperin, gig2, irf7, trim25 and Mxb mRNAs in dsRNA challenged larvae under both thermal regimes: TR and TCh...
  8. Xu Q, Chang M, Xiao F, Huang B, Nie P. The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Vet Immunol Immunopathol. 2010;134:269-78 pubmed publisher
    ..The expression of gcIRF-5 was observed in all organs examined. The analysis of real-time quantitative RT-PCR revealed that grass carp reovirus (GCRV) induced the expression of gcIRF-5 in spleen and head kidney. ..
  9. Huang B, Qi Z, Xu Z, Nie P. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunol. 2010;11:22 pubmed publisher
    ..However, the ten IRF family members in vertebrates and those IRF-like genes in non-vertebrate deuterostomes were quite different in those analyzed characters, as they might have undergone different patterns of evolution. ..

More Information

Publications22

  1. Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
    ..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..
  2. Zhang Q, Meng F, Chen S, Plouffe S, Wu S, Liu S, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017;19:362-374 pubmed publisher
    ..Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defence. ..
  3. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
  4. Shan S, Qi C, Zhu Y, Li H, An L, Yang G. Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense. Fish Shellfish Immunol. 2016;52:94-102 pubmed publisher
    ..Furthermore, we also isolate the peripheral blood leukocytes (PBLs) and find that there is a relevance between the expression profile of CcIRF-1 and IFN in poly(I:C) stimulated PBLs. ..
  5. Lu L, Li S, Lu X, Zhang Y. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7. Fish Shellfish Immunol. 2015;45:574-82 pubmed publisher
    ..b>IRF7 is the master regulator of type I IFN expression...
  6. Lu X, Li X, He Q, Gao J, Gao Y, Liu B, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23:1356-68 pubmed publisher
    ..Mechanistically, miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling...
  7. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
  8. Shi J, Zhang Y, Zhang J, Gui J. Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis. Dev Comp Immunol. 2013;41:534-43 pubmed publisher
    ..IRF9 promoter could be activated by zebrafish IFN?s and zebrafish IFN?2, as well as transcription factors IRF3, IRF7, and combination of IRF9 and STAT2...
  9. Boltaña S, Rey S, Roher N, Vargas R, Huerta M, Huntingford F, et al. Behavioural fever is a synergic signal amplifying the innate immune response. Proc Biol Sci. 2013;280:20131381 pubmed publisher
    ..Given the effects of behavioural fever on survival and the fact that it exists across considerable phylogenetic space, such immunity-environment interactions are likely to be under strong positive selection. ..
  10. Lee S, Peng K, Lee L, Pan C, Hour A, Her G, et al. Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Vet Immunol Immunopathol. 2013;151:217-28 pubmed publisher
    ..These data indicate that such altered expression may account for the improvement in bacterial clearance following electroporation of viperin, suggesting that fish viperin has antiviral and antibacterial activities. ..
  11. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
  12. Lu X, Wei Y, Liu F. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell Discov. 2015;1:15027 pubmed publisher
    ..Therefore, our work reveals the significance of the miR-142a-3p-p53 pathway in controlling hematopoietic stem and progenitor cell survival, and thus advances our understanding of the role of p53 in vertebrate hematopoiesis. ..
  13. Liu X, Cai X, Zhang D, Xu C, Xiao W. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. J Immunol. 2016;197:4736-4749 pubmed
    ..We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic ..