irf3

Summary

Gene Symbol: irf3
Description: interferon regulatory factor 3
Alias: interferon regulatory factor 3
Species: zebrafish

Top Publications

  1. Sun F, Zhang Y, Liu T, Shi J, Wang B, Gui J. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol. 2011;187:2531-9 pubmed publisher
    ..IFN regulatory factor 3 (IRF3) is required for the activation of IFN-?, which, in turn, primes the expression of most IFN-? genes by IFN-induced ..
  2. Feng H, Zhang Q, Zhang Y, Li Z, Zhang J, Xiong Y, et al. Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN?1 and IFN?3 Expression through Assembly of Homo- or Heteroprotein Complexes. J Immunol. 2016;197:1893-904 pubmed publisher
    In mammals, IFN regulatory factor (IRF)1, IRF3, and IRF7 are three critical transcription factors that are pivotal for cooperative regulation of the type I IFN response...
  3. Tong C, Zhang C, Zhang R, Zhao K. Transcriptome profiling analysis of naked carp (Gymnocypris przewalskii) provides insights into the immune-related genes in highland fish. Fish Shellfish Immunol. 2015;46:366-77 pubmed publisher
  4. Huang Y, Huang X, Cai J, Ouyang Z, Wei S, Wei J, et al. Identification of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 3 involved in antiviral immune response against fish RNA virus. Fish Shellfish Immunol. 2015;42:345-52 pubmed publisher
    b>Interferon regulatory factor 3 (IRF3) is an important transcription factor which regulates the expression of interferon (IFN) and IFN-stimulated genes (ISGs) following virus recognition...
  5. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..Co-immunoprecipitation and Western blot experiments indicated that MITA and IRF3 were significantly phosphorylated by TBK1, and that the N-terminal kinase domain of TBK1 was critical in this ..
  6. Feng W, Gu Y, Nie L, Guo D, Xiang L, Shao J. Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation. J Immunol. 2016;197:151-67 pubmed publisher
    ..This molecule is essential to establish liver homeostasis under inflammatory stimuli. Overall, the results will enrich the current knowledge about SIGIRR-mediated immunity and disorders in the liver. ..
  7. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  8. Lee S, Peng K, Lee L, Pan C, Hour A, Her G, et al. Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Vet Immunol Immunopathol. 2013;151:217-28 pubmed publisher
    ..These data indicate that such altered expression may account for the improvement in bacterial clearance following electroporation of viperin, suggesting that fish viperin has antiviral and antibacterial activities. ..
  9. Shan S, Qi C, Zhu Y, Li H, An L, Yang G. Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense. Fish Shellfish Immunol. 2016;52:94-102 pubmed publisher
    ..Furthermore, we also isolate the peripheral blood leukocytes (PBLs) and find that there is a relevance between the expression profile of CcIRF-1 and IFN in poly(I:C) stimulated PBLs. ..

More Information

Publications23

  1. Brun N, Christen V, Furrer G, Fent K. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Environ Sci Technol. 2014;48:11679-87 pubmed publisher
    ..Our study provides first evidence of ER stress and oxidative stress induction by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation. ..
  2. Garcia Valtanen P, Martínez López A, López Muñoz A, Bello Perez M, Medina Gali R, Ortega Villaizan M, et al. Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Front Immunol. 2017;8:121 pubmed publisher
    ..From this and other studies, it might be concluded that some of the characteristics of mammalian trained immunity are present in lower vertebrates. ..
  3. Lu L, Li S, Lu X, Zhang Y. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7. Fish Shellfish Immunol. 2015;45:574-82 pubmed publisher
    ..the activation of IFN1 promoter that induced by IRF7 in a dose-dependent manner, whereas it had little effect on IRF3, a close relative of IRF7...
  4. Li S, Lu L, Feng H, Wu N, Chen D, Zhang Y, et al. IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. J Immunol. 2014;193:1100-9 pubmed publisher
    ..Collectively, these data suggest that DrIRF10 inhibits the expression of DrIFN1 and DrIFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates. ..
  5. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  6. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
  7. Liu X, Cai X, Zhang D, Xu C, Xiao W. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. J Immunol. 2016;197:4736-4749 pubmed
    ..We found that foxo3b interacted with irf3 and irf7 to inhibit ifr3/irf7 transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-..
  8. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
  9. Shi J, Zhang Y, Zhang J, Gui J. Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis. Dev Comp Immunol. 2013;41:534-43 pubmed publisher
    ..zebrafish IRF9 promoter could be activated by zebrafish IFN?s and zebrafish IFN?2, as well as transcription factors IRF3, IRF7, and combination of IRF9 and STAT2...
  10. Biacchesi S, Merour E, Lamoureux A, Bernard J, Bremont M. Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I. PLoS ONE. 2012;7:e47737 pubmed publisher
    ..The Sequences presented in this article have been submitted to GenBank under accession numbers: Zebrafish STING (HE856619); EPC STING (HE856620); EPC IRF3 (HE856621); EPC IFN promoter (HE856618).
  11. Cui H, Yan Y, Wei J, Huang X, Huang Y, Ouyang Z, et al. Identification and functional characterization of an interferon regulatory factor 7-like (IRF7-like) gene from orange-spotted grouper, Epinephelus coioides. Dev Comp Immunol. 2011;35:672-84 pubmed publisher
    ..These results suggest that EcIRF7 is potentially involved in grouper immune responses to invasion of viral and bacterial pathogens...
  12. Dios S, Romero A, Chamorro R, Figueras A, Novoa B. Effect of the temperature during antiviral immune response ontogeny in teleosts. Fish Shellfish Immunol. 2010;29:1019-27 pubmed publisher
    ..the expression levels of several antiviral and inflammatory genes (IL-1?, iNOS, TNF-?, TLR3, IFN-I, IFN?, IRF3, MDA-5, Mx) constitutively and after viral stimulation during early development...
  13. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
  14. Huang B, Qi Z, Xu Z, Nie P. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunol. 2010;11:22 pubmed publisher
    ..However, the ten IRF family members in vertebrates and those IRF-like genes in non-vertebrate deuterostomes were quite different in those analyzed characters, as they might have undergone different patterns of evolution. ..