irf1b

Summary

Gene Symbol: irf1b
Description: interferon regulatory factor 1b
Alias: IRF1, irf11, sb:eu922, zgc:103566, interferon regulatory factor 1, interferon regulatory factor 11
Species: zebrafish

Top Publications

  1. Cui S, Eauclaire S, Matthews R. Interferon-gamma directly mediates developmental biliary defects. Zebrafish. 2013;10:177-83 pubmed publisher
    ..These results support an importance of IFN? in mediating biliary defects, and also demonstrate the feasibility of direct injection of intact protein into developing zebrafish larvae. ..
  2. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
  3. Tang V, COFER Z, Cui S, Sapp V, Loomes K, Matthews R. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr. 2016;63:524-530 pubmed
    ..Our results support previous studies identifying ADD3 as a putative genetic risk factor for BA susceptibility. Our results also provide evidence that add3a may be affecting the Hh pathway, an important factor in BA pathogenesis. ..
  4. Fan H, Liu Y, Wang L, Du T, Dong M, Gao L, et al. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124:1320-30 pubmed publisher
    ..was mainly mediated by the abnormally activated IFN-? signaling, especially the upregulation of stat1a and irf1b. Taken together, we uncovered a novel role of miR-142-3p in maintaining normal neutrophil development and ..
  5. Ruan B, Chen S, Hou J, Huang B, Laghari Z, Li L, et al. Two type II IFN members, IFN-? and IFN-? related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish Shellfish Immunol. 2017;65:103-110 pubmed publisher
    ..and the true homologous gene of mammalian IRF1 in fish was revealed despite the report of so-called IRF1a and IRF1b in zebrafish...
  6. Cui H, Yan Y, Wei J, Huang X, Huang Y, Ouyang Z, et al. Identification and functional characterization of an interferon regulatory factor 7-like (IRF7-like) gene from orange-spotted grouper, Epinephelus coioides. Dev Comp Immunol. 2011;35:672-84 pubmed publisher
    ..These results suggest that EcIRF7 is potentially involved in grouper immune responses to invasion of viral and bacterial pathogens...
  7. Feng H, Zhang Q, Zhang Y, Li Z, Zhang J, Xiong Y, et al. Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN?1 and IFN?3 Expression through Assembly of Homo- or Heteroprotein Complexes. J Immunol. 2016;197:1893-904 pubmed publisher
    ..In this study, we explored the relative contribution of zebrafish (Danio rerio) IRF1 (DrIRF1), IRF3 (DrIRF3), and IRF7 (DrIRF7) (DrIRF1/3/7) to zebrafish IFN?1 (DrIFN?1) and IFN?3 (DrIFN?3) (DrIFN?1/3)..
  8. Lu X, Xiang Y, Yang G, Zhang L, Wang H, Zhong S. Transcriptomic characterization of zebrafish larvae in response to mercury exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2017;192:40-49 pubmed publisher
    ..Thus, these findings provide useful insights to help further understand the transcriptional response and detoxification ability of zebrafish larvae following acute exposure to mercury. ..
  9. Wu Z, Zhang W, Lu Y, Lu C. Transcriptome profiling of zebrafish infected with Streptococcus suis. Microb Pathog. 2010;48:178-87 pubmed publisher
    ..The data may provide further validation of this model, which will contribute to understanding of S. suis pathogenic mechanisms. ..

More Information

Publications13

  1. Matthews R, Eauclaire S, Mugnier M, Lorent K, Cui S, Ross M, et al. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Hepatology. 2011;53:905-14 pubmed publisher
  2. Filiano A, Xu Y, Tustison N, Marsh R, Baker W, Smirnov I, et al. Unexpected role of interferon-? in regulating neuronal connectivity and social behaviour. Nature. 2016;535:425-9 pubmed
  3. Huang B, Qi Z, Xu Z, Nie P. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunol. 2010;11:22 pubmed publisher
    ..However, the ten IRF family members in vertebrates and those IRF-like genes in non-vertebrate deuterostomes were quite different in those analyzed characters, as they might have undergone different patterns of evolution. ..
  4. Shan S, Qi C, Zhu Y, Li H, An L, Yang G. Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense. Fish Shellfish Immunol. 2016;52:94-102 pubmed publisher
    ..Furthermore, we also isolate the peripheral blood leukocytes (PBLs) and find that there is a relevance between the expression profile of CcIRF-1 and IFN in poly(I:C) stimulated PBLs. ..