Gene Symbol: insl5b
Description: insulin-like 5b
Alias: rfla2, insulin-like 5b, relaxin 3d, relaxin family locus A type 2, rlnd, rlx3d
Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al
. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
Yegorov S, Good Avila S, Parry L, Wilson B. Relaxin family genes in humans and teleosts. Ann N Y Acad Sci. 2009;1160:42-4 pubmed publisher
..We found evidence that teleosts harbor orthologs of the human INSL5, H2, H3, and INSL3 genes, so-named RLND/RLNE, RLNC, RLN3a/RLN3b, and RLNF in teleosts, respectively...
Good Avila S, Yegorov S, Harron S, Bogerd J, Glen P, Ozon J, et al
. Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evol Biol. 2009;9:293 pubmed publisher
..which we call rln3a and rln3b, an orthologue of human RLN2, rln, two paralogous copies of human INSL5, insl5a and insl5b, and an orthologue of human INSL3, insl3...
Good S, Yegorov S, Martijn J, Franck J, Bogerd J. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Int J Evol Biol. 2012;2012:310278 pubmed
..Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. ..