Gene Symbol: insl5a
Description: insulin-like 5a
Alias: RFLA1, insl5, rlx3b, insulin-like 5a, insulin-like 5, relaxin 3b, relaxin family locus A type 1, rlne
Wilkinson T, Speed T, Tregear G, Bathgate R. Evolution of the relaxin-like peptide family. BMC Evol Biol. 2005;5:14 pubmed publisher
..structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised...
Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
Wilson B, Burnett D, Rappaport R, Parry L, Fletcher E. Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish. Comp Biochem Physiol A Mol Integr Physiol. 2009;153:69-74 pubmed publisher
..Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development. ..
Yegorov S, Good Avila S, Parry L, Wilson B. Relaxin family genes in humans and teleosts. Ann N Y Acad Sci. 2009;1160:42-4 pubmed publisher
..We found evidence that teleosts harbor orthologs of the human INSL5, H2, H3, and INSL3 genes, so-named RLND/RLNE, RLNC, RLN3a/RLN3b, and RLNF in teleosts, respectively...
Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al
. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
Good Avila S, Yegorov S, Harron S, Bogerd J, Glen P, Ozon J, et al
. Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evol Biol. 2009;9:293 pubmed publisher
..human RLN3, which we call rln3a and rln3b, an orthologue of human RLN2, rln, two paralogous copies of human INSL5, insl5a and insl5b, and an orthologue of human INSL3, insl3...
Good S, Yegorov S, Martijn J, Franck J, Bogerd J. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Int J Evol Biol. 2012;2012:310278 pubmed
..Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. ..