insl3

Summary

Gene Symbol: insl3
Description: insulin-like 3 (Leydig cell)
Alias: RFLX, rln2, rln3c, rlx3c, si:rp71-39b20.5, relaxin 3c, relaxin 2, relaxin 3-like protein c, relaxin family locus X, rlnc
Species: zebrafish

Top Publications

  1. Good Avila S, Yegorov S, Harron S, Bogerd J, Glen P, Ozon J, et al. Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis. BMC Evol Biol. 2009;9:293 pubmed publisher
    ..orthologue of human RLN2, rln, two paralogous copies of human INSL5, insl5a and insl5b, and an orthologue of human INSL3, insl3...
  2. García López A, De Jonge H, Nóbrega R, de Waal P, van Dijk W, Hemrika W, et al. Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins. Endocrinology. 2010;151:2349-60 pubmed publisher
  3. Wilkinson T, Speed T, Tregear G, Bathgate R. Evolution of the relaxin-like peptide family. BMC Evol Biol. 2005;5:14 pubmed publisher
    ..peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised...
  4. Park J, Semyonov J, Chang C, Yi W, Warren W, Hsu S. Origin of INSL3-mediated testicular descent in therian mammals. Genome Res. 2008;18:974-85 pubmed publisher
    ..Recent studies show that INSL3, produced by Leydig cells, and its receptor LGR8 (RXFP2) are essential for mediating the transabdominal phase of ..
  5. Skaar K, Nóbrega R, Magaraki A, Olsen L, Schulz R, Male R. Proteolytically activated, recombinant anti-mullerian hormone inhibits androgen secretion, proliferation, and differentiation of spermatogonia in adult zebrafish testis organ cultures. Endocrinology. 2011;152:3527-40 pubmed publisher
    ..In conclusion, zebrafish Amh is processed to become bioactive and has independent functions in inhibiting both steroidogenesis and spermatogenesis...
  6. Good S, Yegorov S, Martijn J, Franck J, Bogerd J. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Int J Evol Biol. 2012;2012:310278 pubmed
    ..Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals. ..
  7. Morais R, Crespo D, Nóbrega R, Lemos M, van de Kant H, De Franca L, et al. Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh. Mol Cell Endocrinol. 2017;454:112-124 pubmed publisher
    ..Our data suggest that an important aspect of Fsh bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3. ..
  8. Safian D, Morais R, Bogerd J, Schulz R. Igf Binding Proteins Protect Undifferentiated Spermatogonia in the Zebrafish Testis Against Excessive Differentiation. Endocrinology. 2016;157:4423-4433 pubmed
  9. Morais R, Nóbrega R, Gómez González N, Schmidt R, Bogerd J, França L, et al. Thyroid hormone stimulates the proliferation of Sertoli cells and single type A spermatogonia in adult zebrafish (Danio rerio) testis. Endocrinology. 2013;154:4365-76 pubmed publisher
    ..Taken together, our studies suggest that T3 expands the population of SCs and A(und) involving Igf signaling and potentiates gonadotropin-stimulated testicular androgen production as well as androgen sensitivity. ..

More Information

Publications18

  1. Hinfray N, Nobrega R, Caulier M, Baudiffier D, Maillot Marechal E, Chadili E, et al. Cyp17a1 and Cyp19a1 in the zebrafish testis are differentially affected by oestradiol. J Endocrinol. 2013;216:375-88 pubmed publisher
    ..Further studies are needed to elucidate the functionality of steroidogenic enzymes in germ cells and their potential role in testicular physiology. ..
  2. Yegorov S, Good Avila S, Parry L, Wilson B. Relaxin family genes in humans and teleosts. Ann N Y Acad Sci. 2009;1160:42-4 pubmed publisher
    ..We found evidence that teleosts harbor orthologs of the human INSL5, H2, H3, and INSL3 genes, so-named RLND/RLNE, RLNC, RLN3a/RLN3b, and RLNF in teleosts, respectively...
  3. Nobrega R, Greebe C, van de Kant H, Bogerd J, de França L, Schulz R. Spermatogonial stem cell niche and spermatogonial stem cell transplantation in zebrafish. PLoS ONE. 2010;5: pubmed publisher
    ..This might be attributed to the testicular microenvironment created after busulfan depletion in the recipients, which may have caused an imbalance between factors regulating self-renewal or differentiation of the transplanted SSCs. ..
  4. Zucchi S, Castiglioni S, Fent K. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Environ Sci Technol. 2013;47:12548-56 pubmed publisher
    ..The data show molecular effects and the modes of action of P4 at environmental concentrations. Ultimately they may translate to adverse effects on reproduction. ..
  5. Assis L, Crespo D, Morais R, França L, Bogerd J, Schulz R. INSL3 stimulates spermatogonial differentiation in testis of adult zebrafish (Danio rerio). Cell Tissue Res. 2016;363:579-88 pubmed publisher
    b>INSL3 (insulin-like peptide 3) is a relaxin peptide family member expressed by Leydig cells in the vertebrate testis. In mammals, INSL3 mediates testicular descent during embryogenesis but information on its function in adults is limited...
  6. Crespo D, Assis L, Furmanek T, Bogerd J, Schulz R. Expression profiling identifies Sertoli and Leydig cell genes as Fsh targets in adult zebrafish testis. Mol Cell Endocrinol. 2016;437:237-251 pubmed publisher
    ..Fish Leydig cells express the Fsh receptor and one of the most robust Fsh-responsive genes was insulin-like 3 (insl3), a Leydig cell-derived growth factor...
  7. Donizetti A, Grossi M, Pariante P, D Aniello E, Izzo G, Minucci S, et al. Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin-3 gene: first evidence of nucleus incertus in fish. Dev Dyn. 2008;237:3864-9 pubmed publisher
    ..This pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish and rat brains, where only scattered cells express the gene in the periaqueductal gray. ..
  8. Tang H, Chen Y, Liu Y, Yin Y, Li G, Guo Y, et al. New Insights Into the Role of Estrogens in Male Fertility Based on Findings in Aromatase-Deficient Zebrafish. Endocrinology. 2017;158:3042-3054 pubmed publisher
    ..Collectively, our findings indicate that estrogens are not needed to achieve and maintain normal fertility in male zebrafish. This finding challenges the traditional view that estrogens are indispensable for male fertility. ..
  9. Wilson B, Burnett D, Rappaport R, Parry L, Fletcher E. Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish. Comp Biochem Physiol A Mol Integr Physiol. 2009;153:69-74 pubmed publisher
    ..Relaxin-3 appeared to suppress the release of MIS production. This suggests that relaxin peptides may be involved with estradiol-dependant events in follicular development. ..