Gene Symbol: ilk
Description: integrin-linked kinase
Alias: zgc:65842, integrin-linked protein kinase, loc, lost-contact, main squeeze, msq, zilk
Species: zebrafish
Products:     ilk

Top Publications

  1. Knoll R, Postel R, Wang J, Kr├Ątzner R, Hennecke G, Vacaru A, et al. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007;116:515-25 pubmed to identify the lost-contact (loc) mutant, which encodes a nonsense mutation in the integrin-linked kinase (ilk) gene...
  2. Myhre J, Hills J, Jean F, Pilgrim D. Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish. Dev Biol. 2014;390:26-40 pubmed publisher
    ..This represents a novel role for Unc45b in the earliest stages of muscle development that is independent of muscle mMHC folding. ..
  3. Zhang R, Yang J, Zhu J, Xu X. Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Hum Mol Genet. 2009;18:4130-40 pubmed publisher inducible by stretch force, and the expression level of Tcap is negatively regulated by integrin-link kinase (ILK), a protein kinase that is involved in stretch sensing signaling...
  4. Sztal T, Sonntag C, Hall T, Currie P. Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle. Hum Mol Genet. 2012;21:4718-31 pubmed publisher
    ..Collectively these findings provide a better understanding of the cellular pathology of MDC1A and help in designing effective therapies. ..
  5. Postel R, Margadant C, Fischer B, Kreft M, Janssen H, Secades P, et al. Kindlin-1 mutant zebrafish as an in vivo model system to study adhesion mechanisms in the epidermis. J Invest Dermatol. 2013;133:2180-90 pubmed publisher
    ..Whereas both Integrin-linked kinase (Ilk) and Kindlin-1 cooperate with Integrin ?3?1 to resist trauma-induced epidermal defects, Kindlin-1 and Ilk, ..
  6. Subramanian A, Schilling T. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. elife. 2014;3: pubmed publisher
    ..Thus Tsp4 functions as an ECM scaffold at MTJs, with potential therapeutic uses in tendon strengthening and repair. ..
  7. Friedrich E, Liu E, Sinha S, Cook S, Milstone D, Macrae C, et al. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol. 2004;24:8134-44 pubmed
    Integrin-linked kinase (ILK) is a phosphoinositide 3-kinase-dependent serine/threonine kinase that interacts with beta integrins...
  8. Bendig G, Grimmler M, Huttner I, Wessels G, Dahme T, Just S, et al. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 2006;20:2361-72 pubmed
    ..In the hearts of the ethylnitros-urea (ENU)-induced, recessive embryonic lethal zebrafish heart failure mutant main squeeze (msq), we find stretch-responsive genes such as atrial natriuretic factor (anf) and vascular endothelial growth ..
  9. Postel R, Vakeel P, Topczewski J, Knoll R, Bakkers J. Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Dev Biol. 2008;318:92-101 pubmed publisher
    ..Here we show that the zebrafish lost-contact mutant, that lacks a functional integrin-linked kinase (ilk) gene, suffers from mechanical instability of skeletal muscle fibres...

More Information


  1. Vogel B, Meder B, Just S, Laufer C, Berger I, Weber S, et al. In-vivo characterization of human dilated cardiomyopathy genes in zebrafish. Biochem Biophys Res Commun. 2009;390:516-22 pubmed publisher
    ..Our results indicate that the zebrafish is a suitable model organism to rapidly evaluate novel DCM disease genes in-vivo. ..
  2. Meder B, Huttner I, Sedaghat Hamedani F, Just S, Dahme T, Frese K, et al. PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling. Mol Cell Biol. 2011;31:3424-35 pubmed publisher
    Integrin-linked kinase (ILK) is an essential component of the cardiac mechanical stretch sensor and is bound in a protein complex with parvin and PINCH proteins, the so-called ILK-PINCH-parvin (IPP) complex...
  3. Kartopawiro J, Bower N, Karnezis T, Kazenwadel J, Betterman K, Lesieur E, et al. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. 2014;23:1286-97 pubmed publisher
    ..Our data refine common mechanisms that are likely to contribute during both development and the pathogenesis of lymphatic vascular disorders...
  4. Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
    ..These findings describe the cause of a rare subtype of AF due to a primary, atrial-specific sarcomeric defect. ..
  5. Yuan J, He B, Yang L, Guo C, Weng S, Li S, et al. Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. J Virol. 2015;89:763-75 pubmed publisher
    ..protein, which shows high similarity to the dominant negative form of integrin-linked kinase (ILK); i.e., viral ORF119L lacks the ILK kinase domain...