il4

Summary

Gene Symbol: il4
Description: interleukin 4
Alias: il-4, il4/13b, interleukin 4, interleukin 4/13B
Species: zebrafish

Top Publications

  1. Mitra S, Alnabulsi A, Secombes C, Bird S. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. FEBS J. 2010;277:128-47 pubmed publisher
    ..These transcription factors, together with many of the cytokines that are expressed by different T-cell subtypes, will aid future investigations into the Th and T(reg) cell types that exist in teleosts. ..
  2. Zhu L, Pan P, Fang W, Shao J, Xiang L. Essential role of IL-4 and IL-4R? interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. J Immunol. 2012;188:5571-84 pubmed publisher
    ..These results add greater insight into the evolutionary history of adaptive immunity. ..
  3. Lin A, Xiang L, Wang Q, Dong W, Gong Y, Shao J. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity. J Immunol. 2009;183:7398-410 pubmed publisher
    ..We hope that the present study will contribute to a better cross-species understanding of the evolutionary history of the DC-SIGN/CD209 family. ..
  4. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher
  5. Pai W, Hsu C, Lai C, Chang T, Tsai Y, Her G. Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish. Transgenic Res. 2013;22:823-38 pubmed publisher
    ..This study is the first to report CB1R as a potential hepatic stimulator for zebrafish liver steatosis. ..
  6. Yang C, Li Z, Kang W, Tian Y, Yan Y, Chen W. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 2016;591:201-208 pubmed publisher
    ..This is the first report to show that TET family members play indispensable roles in Th2-type immunity, indicating an epigenetic modulation manner involved in adaptive immune regulations and responses. ..
  7. Xu X, Hu J, Ma J, Nie L, Shao T, Xiang L, et al. Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. J Immunol. 2016;196:1686-99 pubmed publisher
    ..This study enriches the current knowledge on TIM-mediated immunity and provides a cross-species understanding of the evolutionary history of costimulatory systems throughout vertebrate evolution. ..
  8. Pase L, Layton J, Kloosterman W, Carradice D, Waterhouse P, Lieschke G. miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood. 2009;113:1794-804 pubmed publisher
    ..These studies define a new genetic pathway promoting erythroid maturation (mnr/miR-451/gata2) and provide a rare example of partial rescue of a mutant phenotype solely by miRNA overexpression...
  9. Al Samadi A, Awad S, Tuomainen K, Zhao Y, Salem A, Parikka M, et al. Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models. Oncotarget. 2017;8:60123-60134 pubmed publisher
    ..In zebrafish, the amount of IL-13 mRNA was decreased by SCC-25 EVs. This study describes promising in vitro and in vivo models to investigate interactions between immune cells, cancer cells, and EVs. ..

More Information

Publications25

  1. Wu S, Wang L, Xu G, Yang S, Deng Q, Li Y, et al. spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization. Fish Shellfish Immunol. 2017;67:684-691 pubmed publisher
    ..Taken together, our data revealed that spv locus could aggravate Salmonella infection of zebrafish adult by inducing an imbalance of Th1/Th2 immune response and resulting in a detrimental Th2 bias of host. ..
  2. Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
  3. Yang Z, Li C, Chen J, Zhang H, Li M, Chen J. Molecular characterization of an interleukin-4/13B homolog in grass carp (Ctenopharyngodon idella) and its role in fish against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2016;57:136-147 pubmed publisher
    Mammalian interleukin 4 (IL-4) and interleukin 13 (IL-13) molecules are anti-inflammatory cytokines mediating the alternative activation of macrophages...
  4. Wang T, Johansson P, Abós B, Holt A, Tafalla C, Jiang Y, et al. First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities. Oncotarget. 2016;7:10917-46 pubmed publisher
    ..It contributes to a broader understanding of the evolution of type-2 immunity in vertebrates, and establishes a framework for further studies and manipulation of type-2 cytokines in fish. ..
  5. Yan C, Huo X, Wang S, Feng Y, Gong Z. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol. 2015;63:420-8 pubmed publisher
    ..An inflammatory cue from oncogenic hepatocytes upon induction of kras(V12) expression causes a rapid recruitment of neutrophils to oncogenic liver and the neutrophils play a promoting role in early hepatocarcinogenesis. ..
  6. Kallakuri S, Yu J, Li J, Li Y, Weinstein B, Nicoli S, et al. Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol. 2015;26:864-75 pubmed publisher
    ..These results suggest that Hedgehog signaling is a major mechanism for this novel role of endothelial cilia in establishing vascular integrity. ..
  7. Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
    ..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
  8. Zhang M, Wu H, Li X, Yang M, Chen T, Wang Q, et al. Edwardsiella tarda flagellar protein FlgD: a protective immunogen against edwardsiellosis. Vaccine. 2012;30:3849-56 pubmed publisher
    ..tarda. ..
  9. Ohtani M, Hayashi N, Hashimoto K, Nakanishi T, Dijkstra J. Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish. Immunogenetics. 2008;60:383-97 pubmed publisher
    ..We were unable to determine if the teleost IL-4/13 genes are orthologous to either IL-4 or IL-13, or if these mammalian genes separated later in evolution...
  10. Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
    ..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..
  11. Zhang H, Fang W, Wang D, Gao N, Ding Y, Chen C. The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity. J Hazard Mater. 2014;280:552-60 pubmed publisher
    ..This study demonstrates that PFOA can affect IL expression level through NF-κB, and ILs have an important function in the mediation of Ig secretion. ..
  12. Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
    ..Characteristic gata3/tbx21 has potential as a biomarker for the status of mycobacterial disease...
  13. Ding Y, Liu X, Bu L, Li H, Zhang S. Antimicrobial-immunomodulatory activities of zebrafish phosvitin-derived peptide Pt5. Peptides. 2012;37:309-13 pubmed publisher
    ..hydrophila through its antimicrobial activity as well as preventing zebrafish from the detrimental effects of an excessive inflammatory response via modulating immune functions. ..
  14. Bhattarai P, Thomas A, Cosacak M, Papadimitriou C, Mashkaryan V, Froc C, et al. IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-?42 Aggregation in Adult Zebrafish Brain. Cell Rep. 2016;17:941-948 pubmed publisher
    ..A?42 also induces NSPC proliferation and enhanced neurogenesis. Interleukin-4 (IL4) is activated primarily in neurons and microglia/macrophages in response to A?42 and is sufficient to increase NSPC ..
  15. Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, et al. The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Dev. 2012;7:27 pubmed publisher
    ..Further studies on the role of cxcr5 in mediating neuronal replenishment have the potential to produce clinical ramifications in efforts for regenerative therapeutic applications for human neurological disorders or acute injuries. ..
  16. Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, et al. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067 pubmed publisher
    ..Inside the cytosol, A. hydrophila avoids detection by suppressing NLRs, facilitating its survival and ensuing pathogenesis. ..