il22

Summary

Gene Symbol: il22
Description: interleukin 22
Alias: interleukin 22, IL-24, Ifnphi6
Species: zebrafish

Top Publications

  1. Igawa D, Sakai M, Savan R. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Mol Immunol. 2006;43:999-1009 pubmed
    ..Expression analysis of IL-22, IL-26 and two IFN-gamma genes suggests an active role of these genes in immune responses in fish. ..
  2. Krause C, Pestka S. Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives. Pharmacol Ther. 2005;106:299-346 pubmed
    ..In addition, the genomic analysis led to the discovery of some new members of this family. ..
  3. Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
    ..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
  4. Wang Y, Peng K, Wu J, Chen J. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish Shellfish Immunol. 2014;39:223-30 pubmed publisher
    ..Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production. ..
  5. Costa M, Saraceni P, Forn Cuni G, Dios S, Romero A, Figueras A, et al. IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling. Dev Comp Immunol. 2013;41:746-55 pubmed publisher
    ..We suggest for the first time that IL-22 constitutes a key regulator of inflammatory homeostasis even in distant species such as teleosts, which diverged from mammals more than 350 million years ago. ..
  6. Wu T, Pan C, Lin M, Hsieh J, Hui C, Chen J. In vivo screening of zebrafish microRNA responses to bacterial infection and their possible roles in regulating immune response genes after lipopolysaccharide stimulation. Fish Physiol Biochem. 2012;38:1299-310 pubmed publisher
    ..Our cloning and expression analyses indicated that miR-122, miR-192, and miR-194a play important roles in zebrafish immunology. ..
  7. Hsieh J, Pan C, Chen J. Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish Shellfish Immunol. 2010;29:430-9 pubmed publisher
    ..These results suggest that using TH2-3 as a transgene in zebrafish can effectively inhibit bacterial growth, specifically the V. vulnificus (204) strain for up to 24 h...
  8. Witte M, Huitema L, Nieuwenhuis E, Brugman S. Deficiency in macrophage-stimulating protein results in spontaneous intestinal inflammation and increased susceptibility toward epithelial damage in zebrafish. Zebrafish. 2014;11:542-50 pubmed publisher
  9. Progatzky F, Cook H, Lamb J, Bugeon L, Dallman M. Mucosal inflammation at the respiratory interface: a zebrafish model. Am J Physiol Lung Cell Mol Physiol. 2016;310:L551-61 pubmed publisher

More Information

Publications20

  1. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher
  2. Pan C, Peng K, Lin C, Chen J. Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish Shellfish Immunol. 2011;31:275-85 pubmed publisher
    ..Overall, these results indicate that TH1-5 and chelonianin possess the potential to be novel candidate genes for aquaculture applications to treat fish diseases. ..
  3. Peng K, Pan C, Chou H, Chen J. Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish Shellfish Immunol. 2010;28:905-17 pubmed publisher
    ..These results suggest that using epinecidin-1 as a transgene in zebrafish can effectively inhibit bacterial growth for up to 24h after infection. ..
  4. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  5. Rendueles O, Ferrières L, Fretaud M, Begaud E, Herbomel P, Levraud J, et al. A new zebrafish model of oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria. PLoS Pathog. 2012;8:e1002815 pubmed publisher
  6. Encinas P, Rodriguez Milla M, Novoa B, Estepa A, Figueras A, Coll J. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 2010;11:518 pubmed publisher
  7. Ojanen M, Turpeinen H, Cordova Z, Hammarén M, Harjula S, Parikka M, et al. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
    ..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
  8. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
  9. Qiu X, Lv M, Jian X, Chen D, Zhou H, Zhang A, et al. In vitro characterization of grass carp (Ctenopharyngodon idella) IL-26 in regulating inflammatory factors. Fish Shellfish Immunol. 2017;66:148-155 pubmed publisher
    ..Those results collectively demonstrated the functional role of IL-26 in regulating inflammatory response in fish. ..
  10. Zhang H, Fei C, Wu H, Yang M, Liu Q, Wang Q, et al. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS ONE. 2013;8:e73871 pubmed publisher
    ..The transcriptome profiling with microarray revealed the Th17-like immune response to bath-vaccination with the live attenuated V. anguillarum in zebrafish. ..
  11. Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
    ..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..