Gene Symbol: il21
Description: interleukin 21
Alias: uncharacterized protein LOC100150203
Zhang H, Fei C, Wu H, Yang M, Liu Q, Wang Q, et al
. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS ONE. 2013;8:e73871 pubmed publisher
..The transcriptome profiling with microarray revealed the Th17-like immune response to bath-vaccination with the live attenuated V. anguillarum in zebrafish. ..
Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al
. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
Wang Y, Peng K, Wu J, Chen J. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish Shellfish Immunol. 2014;39:223-30 pubmed publisher
..Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production. ..
Kallakuri S, Yu J, Li J, Li Y, Weinstein B, Nicoli S, et al
. Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol. 2015;26:864-75 pubmed publisher
..These results suggest that Hedgehog signaling is a major mechanism for this novel role of endothelial cilia in establishing vascular integrity. ..
Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
Ai K, Luo K, Li Y, Hu W, Gao W, Fang L, et al
. Expression pattern analysis of IRF4 and its related genes revealed the functional differentiation of IRF4 paralogues in teleost. Fish Shellfish Immunol. 2017;60:59-64 pubmed publisher
..It can regulate immune pathway through IRF5, MyD88, IL21, PGC1?, and NOD2...
Faikoh E, Hong Y, Hu S. Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish Shellfish Immunol. 2014;38:15-24 pubmed publisher
..These results suggest that LEC could be used as an antimicrobial agent and immunostimulant to protect bacteria-infected fish in aquaculture. ..
Zhang H, Fang W, Wang D, Gao N, Ding Y, Chen C. The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity. J Hazard Mater. 2014;280:552-60 pubmed publisher
..This study demonstrates that PFOA can affect IL expression level through NF-ÎºB, and ILs have an important function in the mediation of Ig secretion. ..
Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher