Gene Symbol: il17a/f3
Description: interleukin 17a/f3
Alias: il17-5, si:ch211-63o20.2, interleukin 17a/f3, interleukin 17-5
Gunimaladevi I, Savan R, Sakai M. Identification, cloning and characterization of interleukin-17 and its family from zebrafish. Fish Shellfish Immunol. 2006;21:393-403 pubmed
..The expression of IL-17 in un-stimulated tissues indicates that these genes may play important roles in normal conditions as well. ..
Tokunaga Y, Shirouzu M, Sugahara R, Yoshiura Y, Kiryu I, Ototake M, et al
. Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts. Sci Rep. 2017;7:7536 pubmed publisher
..These findings suggest that the teleost relies heavily on innate immunity. Thus, this model could better highlight innate immunity in animals that lack adaptive immunity than mouse models. ..
Kumari J, Larsen A, Bogwald J, Dalmo R. Interleukin-17D in Atlantic salmon (Salmo salar): molecular characterization, 3D modelling and promoter analysis. Fish Shellfish Immunol. 2009;27:647-59 pubmed publisher
Zhang H, Fei C, Wu H, Yang M, Liu Q, Wang Q, et al
. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS ONE. 2013;8:e73871 pubmed publisher
..The transcriptome profiling with microarray revealed the Th17-like immune response to bath-vaccination with the live attenuated V. anguillarum in zebrafish. ..
Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al
. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
Ojanen M, Turpeinen H, Cordova Z, HammarÃ©n M, Harjula S, Parikka M, et al
. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
Oksanen K, MyllymÃ¤ki H, Ahava M, MÃ¤kinen L, Parikka M, RÃ¤met M. DNA vaccination boosts Bacillus Calmette-GuÃ©rin protection against mycobacterial infection in zebrafish. Dev Comp Immunol. 2016;54:89-96 pubmed publisher
..We conclude that zebrafish is a useful early-phase preclinical model for studying subunit vaccines designed for boosting the effects of BCG. ..
Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher