Gene Symbol: il12ba
Description: interleukin 12Ba
Alias: IL-12 p40, il12b, il12p40.b, zgc:152789, interleukin-12 subunit beta, il-12p40.a, interleukin 12 p40.b, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin-12 p40 subunit
Species: zebrafish

Top Publications

  1. Lugo Villarino G, Balla K, Stachura D, Banuelos K, Werneck M, Traver D. Identification of dendritic antigen-presenting cells in the zebrafish. Proc Natl Acad Sci U S A. 2010;107:15850-5 pubmed publisher
  2. Nascimento D, do Vale A, Tomás A, Zou J, Secombes C, dos Santos N. Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits. Mol Immunol. 2007;44:2277-91 pubmed
    ..piscicida (Phdp). Finally, the importance of nuclear factor (NF)-kappaB on UV-killed Phdp-induced IL-12 p40 and p35 gene transcription was shown by the use of pyrrolidine dithiocarbamate (PDTC). ..
  3. Watzke J, Schirmer K, Scholz S. Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio). Fish Shellfish Immunol. 2007;23:901-5 pubmed
    ..The gene induction required the removal of the chorion prior to lipopolysaccharide exposure. ..
  4. Gong Y, Xiang L, Shao J. CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates. J Immunol. 2009;182:7749-62 pubmed publisher
    ..Our results provide the first evidence for the existence of the functional CD154-CD40-mediated costimulatory pathway and helper T cell regulatory mechanism underlying adaptive immunity in a fish species. ..
  5. Holt A, Mitra S, van der Sar A, Alnabulsi A, Secombes C, Bird S. Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23?) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Mol Immunol. 2011;48:981-91 pubmed publisher
  6. Wittamer V, Bertrand J, Gutschow P, Traver D. Characterization of the mononuclear phagocyte system in zebrafish. Blood. 2011;117:7126-35 pubmed publisher
    ..These findings suggest that mhc2dab:GFP and cd45:DsRed transgenic lines will be instrumental in elucidating the immune response in the zebrafish. ..
  7. Shao T, Zhu L, Nie L, Shi W, Dong W, Xiang L, et al. Characterization of surface phenotypic molecules of teleost dendritic cells. Dev Comp Immunol. 2015;49:38-43 pubmed publisher
    ..Our findings contributed to the current understanding of the evolutionary history of DCs and the DC-regulatory mechanisms of adaptive immunity. ..
  8. Udayangani R, Dananjaya S, Fronte B, Kim C, Lee J, De Zoysa M. Feeding of nano scale oats ?-glucan enhances the host resistance against Edwardsiella tarda and protective immune modulation in zebrafish larvae. Fish Shellfish Immunol. 2017;60:72-77 pubmed publisher
    ..Thus, non-toxic, water soluble and biodegradable NBG from oats could be considered as the potential immunostimulant for larval aquaculture. ..
  9. Kuri P, Ellwanger K, Kufer T, Leptin M, Bajoghli B. A high-sensitivity bi-directional reporter to monitor NF-?B activity in cell culture and zebrafish in real time. J Cell Sci. 2017;130:648-657 pubmed publisher

More Information


  1. Udayangani R, Dananjaya S, Nikapitiya C, Heo G, Lee J, De Zoysa M. Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish Shellfish Immunol. 2017;66:173-184 pubmed publisher