ihha

Summary

Gene Symbol: ihha
Description: Indian hedgehog homolog a
Alias: hha, ihh, indian hedgehog protein, hh[a], qhh
Species: zebrafish
Products:     ihha

Top Publications

  1. Hammond C, Schulte Merker S. Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling. Development. 2009;136:3991-4000 pubmed publisher
    ..Additionally, we demonstrate that the timing of first osteoclast activity positively correlates to Hh levels in both endochondral and dermal bone. ..
  2. Avaron F, Hoffman L, Guay D, Akimenko M. Characterization of two new zebrafish members of the hedgehog family: atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins. Dev Dyn. 2006;235:478-89 pubmed
    We have characterized two new members of the Hedgehog (Hh) family in zebrafish, ihha and dhh, encoding for orthologues of the tetrapod Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh) genes, respectively...
  3. Krauss S, Concordet J, Ingham P. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell. 1993;75:1431-44 pubmed
    ..By expressing shh in transgenic Drosophila embryos, we also demonstrate a strong functional conservation between the fish and fly hh genes. ..
  4. Korzh S, Winata C, Zheng W, Yang S, Yin A, Ingham P, et al. The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Dev Biol. 2011;359:262-76 pubmed publisher
    ..The mechanisms underlying esophageal malformations, however, are poorly understood. Here, we show that zebrafish Ihha signaling from the epithelium acting in parallel, but independently of Shh, controls epithelial and mesenchymal ..
  5. Eames B, Singer A, Smith G, Wood Z, Yan Y, He X, et al. UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol. 2010;341:400-15 pubmed publisher
  6. Winata C, Korzh S, Kondrychyn I, Zheng W, Korzh V, Gong Z. Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Dev Biol. 2009;331:222-36 pubmed publisher
    ..Similar to those in early lung development, conserved expression of Hedgehog (Hh) genes, shha and ihha, in the epithelia, and Hh receptor genes, ptc1 and ptc2, as well as fgf10a in mesenchyme was observed...
  7. Zardoya R, Abouheif E, Meyer A. Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish. Proc Natl Acad Sci U S A. 1996;93:13036-41 pubmed
    ..The presence of four members of the hedgehog gene family in cyprinid fishes was documented and their homologies to known hedgehog genes in other vertebrates were established. ..
  8. Hadzhiev Y, Lele Z, Schindler S, Wilson S, Ahlberg P, Strahle U, et al. Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Dev Biol. 2007;7:75 pubmed
    ..The median fins evolved before paired fins in early craniates, thus the patterning of the median fins may be an ancestral mechanism that controls the outgrowth of skeletogenic appendages in vertebrates. ..
  9. Parkin C, Allen C, Ingham P. Hedgehog signalling is required for cloacal development in the zebrafish embryo. Int J Dev Biol. 2009;53:45-57 pubmed publisher
    ..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes. ..

More Information

Publications27

  1. Armstrong B, Henner A, Stewart S, Stankunas K. Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone. Development. 2017;144:1165-1176 pubmed publisher
    ..This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions atypically to support bone maturation...
  2. Huycke T, Eames B, Kimmel C. Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development. 2012;139:2371-80 pubmed publisher
    ..b>ihha is specifically expressed in a local population of active osteoblasts along the principal growing edge of the bone...
  3. Park S, Davison J, Rhee J, Hruban R, Maitra A, Leach S. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology. 2008;134:2080-90 pubmed publisher
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  4. Yin A, Korzh V, Gong Z. Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants. Biochim Biophys Acta. 2012;1823:236-44 pubmed publisher
    ..Our works established the importance of proper level of Wnt signaling for normal development of swimbladder in zebrafish. ..
  5. Eames B, Yan Y, Swartz M, Levic D, Knapik E, Postlethwait J, et al. Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. PLoS Genet. 2011;7:e1002246 pubmed publisher
    ..showing increased and early expression of such markers as runx2b, collagen type 10a1, and ihh co-orthologs, and ihha mutation suppressed early perichondral bone in PG mutants...
  6. Zeng L, Childs S. The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Dev Biol. 2012;367:178-86 pubmed publisher
    ..Thus although miR-145 is a tissue-restricted microRNA, it plays an essential role in promoting the patterning of both gut layers during gut development via a paracrine mechanism. ..
  7. Yin A, Korzh S, Winata C, Korzh V, Gong Z. Wnt signaling is required for early development of zebrafish swimbladder. PLoS ONE. 2011;6:e18431 pubmed publisher
    ..Our functional analysis data indicated that Wnt/?-catenin signaling is required for swimbladder early development and we also provided evidence for the crosstalk between Wnt and Hh signaling in early swimbladder development. ..
  8. Wang J, Cao J, Dickson A, Poss K. Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. Nature. 2015;522:226-230 pubmed publisher
    ..These findings extend our understanding of tissue interactions during regeneration and have implications for mobilizing epicardial cells for therapeutic heart repair. ..
  9. Kano S, Xiao J, Osorio J, Ekker M, Hadzhiev Y, Muller F, et al. Two lamprey Hedgehog genes share non-coding regulatory sequences and expression patterns with gnathostome Hedgehogs. PLoS ONE. 2010;5:e13332 pubmed publisher
    ..preliminary genome assembly of the sea lamprey Petromyzon marinus indicate that lampreys have two Hh genes, named Hha and Hhb...
  10. Jackman W, Yoo J, Stock D. Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Dev Biol. 2010;10:119 pubmed publisher
    ..We looked for, but did not detect, tooth germ expression of the other known zebrafish hedgehog ligands shhb, dhh, ihha, or ihhb, suggesting that as in mammals, only Shh participates in zebrafish tooth development...
  11. Bhattacharya P, Yan Y, Postlethwait J, Rubin D. Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. J Endocrinol. 2011;211:187-200 pubmed publisher
    ..The considerable evolutionary conservation in genomic structure, synteny relationships, and expression of zebrafish pth2 and pth2r provides a foundation for exploring the endocrine roles of this system in developing vertebrate embryos. ..
  12. Li J, Liang Y, Zhang X, Lu J, Zhang J, Ruan T, et al. Impaired gas bladder inflation in zebrafish exposed to a novel heterocyclic brominated flame retardant tris(2,3-dibromopropyl) isocyanurate. Environ Sci Technol. 2011;45:9750-7 pubmed publisher
    ..For the first time, we report that the gas bladder could be a primary target organ for TBC, and assessment of the gas bladder should be included in toxicity testing protocols of zebrafish embryos. ..
  13. Wang N, Sun Y, Liu J, Wang Y, Zhu Z. Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Dev Genes Evol. 2007;217:299-305 pubmed
  14. Williams L, Timme Laragy A, Goldstone J, McArthur A, Stegeman J, Smolowitz R, et al. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e79574 pubmed publisher
    ..Our results provide a foundation for understanding the role of nrf genes in normal development and in regulating the response to oxidative stress in vertebrate embryos. ..
  15. Jantzen C, Annunziato K, Bugel S, Cooper K. PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression. Aquat Toxicol. 2016;175:160-70 pubmed publisher
    ..PFOS, PFNA, and PFOA exposure resulted in significantly altered responses in terms of morphometric, locomotion, and gene expression endpoints, which could be manifested in field exposed teleosts. ..
  16. DeLaurier A, Huycke T, Nichols J, Swartz M, Larsen A, Walker C, et al. Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Dev Biol. 2014;385:189-99 pubmed publisher
    ..Hence, steps along the developmental trajectory appear differentially sensitive to the loss of buffering, providing focus for the future study. ..
  17. Paul S, Schindler S, Giovannone D, de Millo Terrazzani A, Mariani F, Crump J. Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development. 2016;143:2066-76 pubmed publisher
    ..Analysis of Indian hedgehog homolog a (ihha) mutants shows that the ability of periosteal cells to generate cartilage in response to injury depends on a repair-..
  18. Smith A, Avaron F, Guay D, Padhi B, Akimenko M. Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function. Dev Biol. 2006;299:438-54 pubmed