Gene Symbol: ighz
Description: immunoglobulin heavy constant zeta
Alias: ighm2, igz, immunoglobulin constant zeta
Species: zebrafish
Products:     ighz

Top Publications

  1. Danilova N, Saunders H, Ellestad K, Magor B. The zebrafish IgH locus contains multiple transcriptional regulatory regions. Dev Comp Immunol. 2011;35:352-9 pubmed publisher
    Many fish have, in addition to IgM and IgD, a third isotype called IgZ or IgT. The ?-chain locus is embedded among the Ig heavy chain V-, D- and J-elements in a manner reminiscent of the TcR ?/? locus...
  2. Zimmerman A, Moustafa F, Romanowski K, Steiner L. Zebrafish immunoglobulin IgD: unusual exon usage and quantitative expression profiles with IgM and IgZ/T heavy chain isotypes. Mol Immunol. 2011;48:2220-3 pubmed publisher
    ..human (IgD, IgM, IgA, IgG, IgE), zebrafish harbor gene segments for IgD, IgM, and novel heavy chain isotype called IgZ/T which appears restricted to bony fishes...
  3. Wan F, Hu C, Ma J, Gao K, Xiang L, Shao J. Characterization of ?? T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Front Immunol. 2016;7:675 pubmed publisher
    ..Particularly, zebrafish ?? T cells also play a critical role in antigen-specific IgZ production in intestinal mucus...
  4. Hu Y, Xiang L, Shao J. Identification and characterization of a novel immunoglobulin Z isotype in zebrafish: implications for a distinct B cell receptor in lower vertebrates. Mol Immunol. 2010;47:738-46 pubmed publisher
    ..The newly discovered IgZ/IgZ-like molecules in zebrafish and several other fish species greatly enriched our knowledge of immunoglobulin ..
  5. Page D, Wittamer V, Bertrand J, Lewis K, Pratt D, Delgado N, et al. An evolutionarily conserved program of B-cell development and activation in zebrafish. Blood. 2013;122:e1-11 pubmed publisher
    ..The IgM1:eGFP reporter fish are the first nonmammalian B-cell reporter animals to be described. They will be important for further investigation of immune cell evolution and development and host-pathogen interactions in zebrafish...
  6. Kallakuri S, Yu J, Li J, Li Y, Weinstein B, Nicoli S, et al. Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol. 2015;26:864-75 pubmed publisher
    ..These results suggest that Hedgehog signaling is a major mechanism for this novel role of endothelial cilia in establishing vascular integrity. ..
  7. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  8. Liu X, Li Y, Shinton S, Rhodes J, Tang L, Feng H, et al. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017;199:1706-1715 pubmed publisher
    ..This confirmed a conserved role for CD79 in B cell development and differentiation, without the requirement of a pre-B cell stage in zebrafish. ..
  9. Zhang H, Fang W, Wang D, Gao N, Ding Y, Chen C. The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity. J Hazard Mater. 2014;280:552-60 pubmed publisher
    ..This study demonstrates that PFOA can affect IL expression level through NF-κB, and ILs have an important function in the mediation of Ig secretion. ..

More Information


  1. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  2. Tadiso T, Lie K, Hordvik I. Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of ?, ?, and ? in different tissues. Vet Immunol Immunopathol. 2011;139:17-26 pubmed publisher
    ..The analyses revealed that IgM transcripts are most abundant (up to 200 times more than IgD) followed by IgT (up to 20 times more than IgD) in most tissues. Highest expression of IgM, IgT, and IgD was in head kidney and spleen. ..
  3. Wang Z, Wu Y, Hu Q, Li Y. Differences on the biological function of three Ig isotypes in zebrafish: a gene expression profile. Fish Shellfish Immunol. 2015;44:283-6 pubmed publisher
    ..Overall, IgM and IgZ expression exceeded IgD in both the larvae and adult, and IgM expression exceeded IgZ in the larvae at later ..
  4. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
  5. Lagos L, Tandberg J, Repnik U, Boysen P, Ropstad E, Varkey D, et al. Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..1, and ighm, was upregulated, thus confirming the immunogenic properties of F. noatunensis subsp. orientalis-derived MVs. ..