Gene Symbol: ifnphi1
Description: interferon phi 1
Alias: ifn, ifn1, interferon phi 1, ifnab, interferon 1
Species: zebrafish

Top Publications

  1. López Muñoz A, Roca F, Sepulcre M, Meseguer J, Mulero V. Zebrafish larvae are unable to mount a protective antiviral response against waterborne infection by spring viremia of carp virus. Dev Comp Immunol. 2010;34:546-52 pubmed publisher
    ..Thus, although groups I and II zebrafish IFN show powerful antiviral activities, only group I (IFNphi1) is able to protect the fish against bacterial infection...
  2. Palha N, Guivel Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, et al. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013;9:e1003619 pubmed publisher
    ..As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes...
  3. Robertsen B. The interferon system of teleost fish. Fish Shellfish Immunol. 2006;20:172-91 pubmed
    ..In mammals, three families of IFNs (type I IFN, type II IFN and IFN-lambda) can be distinguished on the basis of gene structure, protein structure and functional ..
  4. Hamming O, Lutfalla G, Levraud J, Hartmann R. Crystal structure of Zebrafish interferons I and II reveals conservation of type I interferon structure in vertebrates. J Virol. 2011;85:8181-7 pubmed publisher
    ..Here we establish the three-dimensional (3D) structure of zebrafish IFN?1 and IFN?2 by crystallography...
  5. Sun F, Zhang Y, Liu T, Shi J, Wang B, Gui J. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol. 2011;187:2531-9 pubmed publisher
    ..Further characterization of distinct IFN gene activation reveals that zebrafish IFN1 and IFN3 are induced by the MITA pathway but are dependent on distinct transcription factors...
  6. Aggad D, Mazel M, Boudinot P, Mogensen K, Hamming O, Hartmann R, et al. The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. J Immunol. 2009;183:3924-31 pubmed publisher
    ..To date, only the receptor for zebrafish IFNphi1 has been identified functionally. Three genes encoding virus-induced IFNphis have been reported in zebrafish...
  7. Stockhammer O, Zakrzewska A, Hegedus Z, Spaink H, Meijer A. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J Immunol. 2009;182:5641-53 pubmed publisher
    ..Finally, we showed that induction of il1b, mmp9, and irak3 requires Myd88-dependent signaling, while ifn1 and il8 were induced Myd88 independently during Salmonella infection.
  8. Sullivan C, Postlethwait J, Lage C, Millard P, Kim C. Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates. J Immunol. 2007;178:4517-27 pubmed
    In mammals, Toll-IL-1R-containing adaptor molecule 1 (TICAM1)-dependent TLR pathways induce NF-kappaB and IFN-beta responses...
  9. Sepulcre M, Alcaraz Pérez F, López Muñoz A, Roca F, Meseguer J, Cayuela M, et al. Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. J Immunol. 2009;182:1836-45 pubmed publisher

More Information


  1. Galindo Villegas J, García Moreno D, de Oliveira S, Meseguer J, Mulero V. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci U S A. 2012;109:E2605-14 pubmed
  2. Altmann S, Mellon M, Distel D, Kim C. Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio. J Virol. 2003;77:1992-2002 pubmed
    The interferon (IFN) family consisting of alpha IFN (IFN-alpha), IFN-beta, IFN-omega, IFN-delta, IFN-kappa, and IFN-tau is a large group of cytokines involved in the innate immune response against various microorganisms...
  3. van Soest J, Stockhammer O, Ordas A, Bloemberg G, Spaink H, Meijer A. Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda. BMC Immunol. 2011;12:58 pubmed publisher
    ..In this study we used transcriptome profiling and quantitative RT-PCR to analyze the immune response induced by E. tarda immersion and injection...
  4. Ludwig M, Palha N, Torhy C, Briolat V, Colucci Guyon E, Bremont M, et al. Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae. PLoS Pathog. 2011;7:e1001269 pubmed publisher
    ..This tractable system will allow the in vivo dissection of host-virus interactions at the whole organism scale, a feature unrivalled by other vertebrate models. ..
  5. Zou J, Tafalla C, Truckle J, Secombes C. Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates. J Immunol. 2007;179:3859-71 pubmed
    In this report, three type I IFN genes were identified in rainbow trout (rt) Oncorhynchus mykiss and are classified into two groups based on their primary protein sequences: group I containing two cysteine residues; and group II ..
  6. Lu M, Chao Y, Guo T, Santi N, Evensen O, Kasani S, et al. The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model. Mol Immunol. 2008;45:1146-52 pubmed
    ..This study is the first to demonstrate NNV infection of zebrafish, which could serve as a potential animal model to study virus pathogenesis and neuron degeneration research...
  7. López Muñoz A, Roca F, Meseguer J, Mulero V. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol. 2009;182:3440-9 pubmed publisher
    ..iniae) and viral (spring viremia of carp virus) infection models, we are reporting in this study that zebrafish IFN (zfIFN) gamma failed to induce antiviral and proinflammatory genes when administered in vivo, which correlates with ..
  8. Novoa B, Romero A, Mulero V, Rodriguez I, Fernandez I, Figueras A. Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 2006;24:5806-16 pubmed
    ..In addition, the high protection obtained with the live attenuated virus demonstrates that the zebrafish is able to mount an efficient antiviral immune response at 15 degrees C...
  9. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  10. Filby A, Paull G, Bartlett E, Van Look K, Tyler C. Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav. 2010;101:576-87 pubmed publisher
    ..The wide-ranging physiological differences seen between dominant and subordinate zebrafish as a consequence of their social status suggest negative health impacts for subordinates after prolonged durations in those hierarchies. ..
  11. Chen H, Liu W, Wu S, Chiou P, Li Y, Chen Y, et al. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015;43:427-35 pubmed publisher
    The type I interferon (IFN) response has been shown to be crucial for the survival of zebrafish larvae infected with nervous necrosis virus (NNV). Teleost type I IFNs can be divided into two groups, based on their cysteine content...
  12. Wang L, Wang L, Zhang H, Zhang J, Chen W, Ruan X, et al. In vitro effects of recombinant zebrafish IFN on spring viremia of carp virus and infectious hematopoietic necrosis virus. J Interferon Cytokine Res. 2006;26:256-9 pubmed
    ..the effects of fish recombinant interferon (rIFN) on fish pathogenic rhabdoviruses, the zebrafish (Danio rerio) IFN (DreIFN) allele B gene was cloned and expressed in Escherichia coli...
  13. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..In this study, we report that zebrafish STAT6 is induced during SVCV infection and reduces IFNφ1 expression by suppressing TBK1 phosphorylation...
  14. Espin Palazon R, Martínez López A, Roca F, López Muñoz A, Tyrkalska S, Candel S, et al. TNF? Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS Pathog. 2016;12:e1005699 pubmed publisher
    ..This mechanism of action provides new therapeutic targets for the treatment of SVCV-infected fish, and advances our understanding of the previously enigmatic deleterious role of TNF? in certain viral infections. ..
  15. Progatzky F, Cook H, Lamb J, Bugeon L, Dallman M. Mucosal inflammation at the respiratory interface: a zebrafish model. Am J Physiol Lung Cell Mol Physiol. 2016;310:L551-61 pubmed publisher
  16. Lagos L, Tandberg J, Repnik U, Boysen P, Ropstad E, Varkey D, et al. Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..1, and ighm, was upregulated, thus confirming the immunogenic properties of F. noatunensis subsp. orientalis-derived MVs. ..
  17. Zhang Q, Meng F, Chen S, Plouffe S, Wu S, Liu S, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017;19:362-374 pubmed publisher
    ..Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defence. ..
  18. Yang Y, Qi S, Wang D, Wang K, Zhu L, Chai T, et al. Toxic effects of thifluzamide on zebrafish (Danio rerio). J Hazard Mater. 2016;307:127-36 pubmed publisher
    ..These might be responsible for the adverse expansion of the apoptosis- and immune-related genes, which would facilitate the action of these factors in programmed cell death and might play a key role during the toxic events. ..
  19. van der Vaart M, van Soest J, Spaink H, Meijer A. Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Dis Model Mech. 2013;6:841-54 pubmed publisher
    ..This zebrafish myd88 mutant will be a valuable tool for further study of the role of IL1R and TLR signaling in the innate immunity processes underlying infectious diseases, inflammatory disorders and cancer...
  20. Feng W, Gu Y, Nie L, Guo D, Xiang L, Shao J. Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation. J Immunol. 2016;197:151-67 pubmed publisher
    ..In contrast, depletion of TIR domain-containing adaptor inducing IFN-? (TRIF) or administration of TRIF signaling inhibitor extremely abrogated the poly(I:C)-induced hepatic ..
  21. Gabor K, Charette J, Pietraszewski M, Wingfield D, Shim J, Millard P, et al. A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance. Dev Comp Immunol. 2015;51:298-304 pubmed publisher
    ..To our knowledge, we have generated the first dominant-negative mda5 transgenic zebrafish and demonstrated a critical role for Mda5 in the antiviral response to rhabdovirus. ..
  22. Zhang M, Wu H, Li X, Yang M, Chen T, Wang Q, et al. Edwardsiella tarda flagellar protein FlgD: a protective immunogen against edwardsiellosis. Vaccine. 2012;30:3849-56 pubmed publisher
    ..tarda. ..
  23. Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P. Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol. 2010;8:e1000562 pubmed publisher
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds. ..
  24. Aleksejeva E, Houel A, Briolat V, Levraud J, Langevin C, Boudinot P. Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Dev Comp Immunol. 2016;57:48-56 pubmed publisher
    ..Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a ..
  25. Gui J, Greene C, Sullivan C, Taylor W, Moore J, KIM C. Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study. BioData Min. 2015;8:17 pubmed publisher
    ..We compared the mRNA expression for each group and found over 200 differentially expressed genes and several enriched pathways including defense response pathways, arsenic response pathways, and the Notch signaling pathway. ..
  26. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
    ..of innate immune-related genes and an increase in the number of cells expressing the zebrafish type I IFN ifnphi1. To our knowledge, this is the first example of an in vivo model of AGS that recapitulates features of both the ..
  27. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
    Interferon (IFN) regulatory factors (IRF) are the crucial transcription factors for IFN expression, leading host cell response to viral infection...
  28. Xiong R, Nie L, Xiang L, Shao J. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. J Immunol. 2012;188:2653-68 pubmed publisher
    ..zfPIAS4a expression can be dramatically induced by the stimulation of polyinosinic-polycytidylic acid and zebrafish IFN1. It acts as a critical negative regulator of the TIR domain-containing adapter inducing IFN-?, mitochondrial ..
  29. Ruyra A, Cano Sarabia M, MacKenzie S, Maspoch D, Roher N. A novel liposome-based nanocarrier loaded with an LPS-dsRNA cocktail for fish innate immune system stimulation. PLoS ONE. 2013;8:e76338 pubmed publisher
    ..The design of a unique delivery system with the ability to stimulate two potent innate immunity pathways virtually present in all fish species represents a completely new approach in fish health. ..
  30. Huang C, Chou C, Lien H, Chu C, Ho J, Wu Y, et al. IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Mar Biotechnol (NY). 2017;19:310-319 pubmed publisher
    ..Induction of transactivation of Mx promoter by zIRF9-S2C shows significantly higher activity than by zebrafish IFN1 (zIFN1), IFNγ (zIFNγ), and Tetraodon IRF9-S2C (TnIRF9-S2C)...
  31. Huang Y, Huang X, Cai J, Ouyang Z, Wei S, Wei J, et al. Identification of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 3 involved in antiviral immune response against fish RNA virus. Fish Shellfish Immunol. 2015;42:345-52 pubmed publisher
    ..regulatory factor 3 (IRF3) is an important transcription factor which regulates the expression of interferon (IFN) and IFN-stimulated genes (ISGs) following virus recognition...
  32. Tokunaga Y, Shirouzu M, Sugahara R, Yoshiura Y, Kiryu I, Ototake M, et al. Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts. Sci Rep. 2017;7:7536 pubmed publisher
    ..These findings suggest that the teleost relies heavily on innate immunity. Thus, this model could better highlight innate immunity in animals that lack adaptive immunity than mouse models. ..
  33. Lin W, Hou J, Guo H, Qiu Y, Li L, Li D, et al. Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish. Chemosphere. 2017;183:315-322 pubmed publisher
    ..serum C3 levels, and significantly upregulated expression of innate immune-related genes (c3b, lyz, il1?, tnf? and ifn?)...
  34. López Muñoz A, Liarte S, Gómez González N, Cabas I, Meseguer J, García Ayala A, et al. Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish. Dev Comp Immunol. 2015;53:55-62 pubmed publisher
    ..demonstrated that mutant fish were able to induce the genes encoding major antiviral molecules, including Ifnphi1, Ifnphi2, Infphi3, Mxb and Mxc, and the negative feedback regulator of cytokine signaling Socs1...
  35. Chen C, Liu W, Wang L, Li J, Chen Y, Jin J, et al. Pathological damage and immunomodulatory effects of zebrafish exposed to microcystin-LR. Toxicon. 2016;118:13-20 pubmed publisher
    ..The transcriptional levels of IFN-1 and IL-8 in spleen significantly up-regulated in 20 ?g/L group, and the transcription of IL-1? and TNF? in ..
  36. Lutfalla G, Roest Crollius H, Stange Thomann N, Jaillon O, Mogensen K, Monneron D. Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 2003;4:29 pubmed
    ..Despite the report of a near complete pufferfish (Takifugu rubripes) genome sequence, these genes remain undescribed in fish...
  37. Candel S, Tyrkalska S, García Moreno D, Meseguer J, Mulero V. Identification of Evolutionarily Conserved Md1 Splice Variants That Regulate Innate Immunity through Differential Induction of NF-?B. J Immunol. 2016;197:1379-88 pubmed publisher
  38. Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, et al. In vivo analysis of Ifn-?1 and Ifn-?2 signaling in zebrafish. J Immunol. 2010;185:6774-82 pubmed publisher
    ..Among receptors for class II helical cytokines-i.e., IFNs that include virus-induced Ifns (Ifn-) and type II Ifns (Ifn-?), together with Il-10 and its related cytokines (Il-20, Il-22, and Il-26)-only the Ifn--..
  39. Jin Y, Liu Z, Peng T, Fu Z. The toxicity of chlorpyrifos on the early life stage of zebrafish: a survey on the endpoints at development, locomotor behavior, oxidative stress and immunotoxicity. Fish Shellfish Immunol. 2015;43:405-14 pubmed publisher
    ..Finally, the mRNA levels of the main cytokines including tumor necrosis factor α (Tnfα), interferon (Ifn), interleukin-1 beta (Il-1β), interleukin 6 (Il6), complement factor 4 (C4) in the larvae increased ..
  40. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  41. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  42. Chen W, Hu Y, Zou P, Ren S, Nie P, Chang M. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49:19-30 pubmed publisher
    ..Overexpression of MAVS_tv1 and MAVS_tv2 in fish cells conferred antiviral resistance, and activated zebrafish IFN1 and IFN3 promoters...
  43. Candel S, Sepulcre M, Espín Palazón R, Tyrkalska S, de Oliveira S, Meseguer J, et al. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Dev Comp Immunol. 2015;50:155-65 pubmed publisher
    ..These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity. ..
  44. Briolat V, Jouneau L, Carvalho R, Palha N, Langevin C, Herbomel P, et al. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. J Immunol. 2014;192:4328-41 pubmed publisher
    ..Chikungunya virus (CHIKV) induces a rapid and protective IFN response...
  45. Yang Y, Liu W, Mu X, Qi S, Fu B, Wang C. Biological response of zebrafish embryos after short-term exposure to thifluzamide. Sci Rep. 2016;6:38485 pubmed publisher
    ..In addition to providing the first description of the mechanism of the toxic effects of thifluzamide on embryos, this study also represents a step towards using embryos to assess mitochondrial metabolism and disease. ..
  46. Lu L, Li S, Lu X, LaPatra S, Zhang N, Zhang X, et al. Spring Viremia of Carp Virus N Protein Suppresses Fish IFN?1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. J Immunol. 2016;196:3744-53 pubmed publisher
    For a virus to replicate efficiently, it must try and inhibit host IFN expression because IFN is an important host defense at early stages after viral infection...
  47. Wu X, Hu Y, Xue N, Ren S, Chen S, Nie P, et al. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Dev Comp Immunol. 2017;68:58-68 pubmed publisher
    ..in significant inhibition of SVCV replication in vivo and in vitro, but failed to activate interferon (IFN) promoters and type I IFN signaling pathway...
  48. Lu L, Li S, Lu X, Zhang Y. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7. Fish Shellfish Immunol. 2015;45:574-82 pubmed publisher
    ..Furthermore, overexpression of MAVS_tv2 decreased the activation of IFN1 promoter that induced by IRF7 in a dose-dependent manner, whereas it had little effect on IRF3, a close relative of ..
  49. Jin Y, Pan X, Cao L, Ma B, Fu Z. Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish Shellfish Immunol. 2013;34:717-23 pubmed publisher
    ..The information presented in this study will help with elucidating the differences and environmental risk of the two enantiomers of cis-BF-induced toxicity in aquatic organisms. ..
  50. Liu Z, Fu Z, Jin Y. Immunotoxic effects of atrazine and its main metabolites at environmental relevant concentrations on larval zebrafish (Danio rerio). Chemosphere. 2017;166:212-220 pubmed publisher
    ..According to these results, both of ATZ and its metabolites exposure could cause the immunotoxicity in larval zebrafish. Thus, we thought that the ecological risks of the metabolites of ATZ on aquatic organisms could not be ignored. ..
  51. Zhang Q, Dong X, Chen B, Zhang Y, Zu Y, Li W. Zebrafish as a useful model for zoonotic Vibrio parahaemolyticus pathogenicity in fish and human. Dev Comp Immunol. 2016;55:159-68 pubmed publisher
    ..The expression levels of three proinflammatory cytokines, interleukin 1β (il1β), interferon phi 1 (ifnϕ1) and tumor necrosis factor α (tnfα), as determined by quantitative real-time PCR, were ..
  52. Correa R, Matsui T, Tergaonkar V, Rodriguez Esteban C, Izpisua Belmonte J, Verma I. Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity. Curr Biol. 2005;15:1291-5 pubmed
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB. ..
  53. Shi J, Zhang Y, Zhang J, Gui J. Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis. Dev Comp Immunol. 2013;41:534-43 pubmed publisher
    We previously showed that a fish interferon (IFN) regulatory factor 9 (IRF9) homologue, crucian carp Carassius auratus IRF9, displays constitutively nuclear localization and involvement in fish IFN-dependent JAK-STAT signaling; however, ..
  54. Dios S, Romero A, Chamorro R, Figueras A, Novoa B. Effect of the temperature during antiviral immune response ontogeny in teleosts. Fish Shellfish Immunol. 2010;29:1019-27 pubmed publisher
    ..used to investigate the expression levels of several antiviral and inflammatory genes (IL-1?, iNOS, TNF-?, TLR3, IFN-I, IFN?, IRF3, MDA-5, Mx) constitutively and after viral stimulation during early development...
  55. Liu X, Cai X, Zhang D, Xu C, Xiao W. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. J Immunol. 2016;197:4736-4749 pubmed
    ..transcriptional activity, thus resulting in suppression of SVCV or polyinosinic-polycytidylic acid-induced IFN activation...
  56. Lepiller S, Franche N, Solary E, Chluba J, Laurens V. Comparative analysis of zebrafish nos2a and nos2b genes. Gene. 2009;445:58-65 pubmed publisher
    ..Thus, the evolution of nos2 genes in zebrafish provides a typical example of gene divergence after duplication. ..
  57. Varela M, Diaz Rosales P, Pereiro P, Forn Cuni G, Costa M, Dios S, et al. Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species. PLoS ONE. 2014;9:e100015 pubmed publisher
    ..The induction of these genes was examined both in vitro and in vivo after interferon (IFN) administration and rhabdovirus challenge...
  58. Varela M, Romero A, Dios S, van der Vaart M, Figueras A, Meijer A, et al. Cellular visualization of macrophage pyroptosis and interleukin-1? release in a viral hemorrhagic infection in zebrafish larvae. J Virol. 2014;88:12026-40 pubmed publisher
    ..The use of this animal model with other pathogens could improve the current knowledge on host-pathogen interactions and increase the potential for the discovery of new therapeutic targets against diverse viral diseases. ..
  59. Clarke B, McColl K, Ward A, Doran T. shRNAs targeting either the glycoprotein or polymerase genes inhibit Viral haemorrhagic septicaemia virus replication in zebrafish ZF4 cells. Antiviral Res. 2017;141:124-132 pubmed publisher
    ..improper hairpin when analysed in silico, induced an antiviral response as measured by induction of interferon (ifnphi1) and Mx (MxA) genes...
  60. Nayak A, Lage C, Kim C. Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio). Toxicol Sci. 2007;98:118-24 pubmed
    ..To our knowledge, this is the first report describing the effects of such low levels of arsenic on host resistance to infection. ..
  61. Dong X, Zhang Z, Meng S, Pan C, Yang M, Wu X, et al. Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. Sci Total Environ. 2018;610-611:291-297 pubmed publisher
  62. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..necrosis virus (ISKNV) and zebrafish model system to investigate the inhibitory effect of recombinant zebrafish interferon 1 (zfrIFN1) on acute viral infection and the impact of time of zfrIFN1 administration on its protective efficacy...
  63. Jia P, Liu W, Chen L, Jin Y, Zhang J, Jia K, et al. Identification of sea perch (Lateolabrax japonicus) ribonucleoprotein PTB-Binding 1 involved in antiviral immune response against RGNNV. Fish Shellfish Immunol. 2017;60:119-128 pubmed publisher
    ..assays demonstrated that overexpression of LjRAVER1 significantly increased the promoter activity of zebrafish IFN1. Taken together, these findings indicated that LjRAVER1 might be an important component of RLR signaling pathway ..
  64. Feng H, Zhang Q, Zhang Y, Li Z, Zhang J, Xiong Y, et al. Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFN?1 and IFN?3 Expression through Assembly of Homo- or Heteroprotein Complexes. J Immunol. 2016;197:1893-904 pubmed publisher
    In mammals, IFN regulatory factor (IRF)1, IRF3, and IRF7 are three critical transcription factors that are pivotal for cooperative regulation of the type I IFN response...
  65. Jin Y, Chen R, Liu W, Fu Z. Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio). Fish Shellfish Immunol. 2010;28:854-61 pubmed publisher
    ..In the present study, we found that the mRNA levels of TNFalpha, IFN, IL-1beta, IL-8, CXCL-Clc, and CC-chemokine, which are closely related to the innate immune system, were affected ..
  66. Liao Z, Wan Q, Su J. Bioinformatics analysis of organizational and expressional characterizations of the IFNs, IRFs and CRFBs in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2016;61:97-106 pubmed publisher
    ..in the mature peptide and can be further divided into three subgroups (IFN-a, -c and -d), containing four members: IFN1, IFN2, IFN3, IFN4 in grass carp...
  67. Morick D, Saragovi A. Inhibition of nervous necrosis virus by ribavirin in a zebrafish larvae model. Fish Shellfish Immunol. 2017;60:537-544 pubmed publisher
    ..Ribavirin treatment of uninfected larvae reduces the basal level of IFN?, but increases the level of IL-1? mRNA expression...
  68. Zhang L, Chen W, Hu Y, Wu X, Nie P, Chang M. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016;54:135-43 pubmed publisher
    ..Overexpression of TBK1 but not TBK1L resulted in significant activation of zebrafish IFN1 and IFN3 promoters. Similarly, TBK1L had little impact on the antiviral state of the cells...
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    ..This proof-of-concept study indicates that the zebrafish represents an amenable model for the investigation of cytosolic DNA sensing mechanisms. ..
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    ..molecular patterns (PAMPs), which induce the production of cytokines, such as type I interferons (IFN)...
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    ..TNF-alpha), a primer of the respiratory burst response, and mRNA expression of the antiviral cytokines interferon (IFN) and MX, : before and after viral infection, were examined in arsenic-exposed zebrafish larvae...
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    ..In addition, the expressions of interferon (IFN) and interferon-induced GTP-binding protein Mx were all up regulated significantly at the late stage of the ..