Gene Symbol: ifngr1
Description: interferon gamma receptor 1
Alias: crfb17, ifngr1-2, zgc:194858, zgc:194873, interferon gamma receptor 1, cytokine receptor family member B17
Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, et al
. In vivo analysis of Ifn-?1 and Ifn-?2 signaling in zebrafish. J Immunol. 2010;185:6774-82 pubmed publisher
..The receptor complex for Ifn-?2 includes cytokine receptor family B (Crfb)6 together with Crfb13 and Crfb17, whereas the receptor complex for Ifn-?1 does not include Crfb6 or Crfb13 but includes Crfb17...
Cui S, Eauclaire S, Matthews R. Interferon-gamma directly mediates developmental biliary defects. Zebrafish. 2013;10:177-83 pubmed publisher
..These results support an importance of IFN? in mediating biliary defects, and also demonstrate the feasibility of direct injection of intact protein into developing zebrafish larvae. ..
Fan H, Liu Y, Wang L, Du T, Dong M, Gao L, et al
. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124:1320-30 pubmed publisher
..Taken together, we uncovered a novel role of miR-142-3p in maintaining normal neutrophil development and maturation. ..
Levitte S, Adams K, Berg R, Cosma C, Urdahl K, Ramakrishnan L. Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo. Cell Host Microbe. 2016;20:250-8 pubmed publisher
..Our work suggests that if pathogenic mycobacteria fail to prevent lysosomal trafficking, they tolerate the resulting acidic environment of the phagolysosome to establish infection. ..
Grayfer L, Belosevic M. Molecular characterization of novel interferon gamma receptor 1 isoforms in zebrafish (Danio rerio) and goldfish (Carassius auratus L.). Mol Immunol. 2009;46:3050-9 pubmed publisher
..that mediates its effects by binding to a receptor complex composed of interferon gamma receptors 1 and 2 (IFNGR1 and IFNGR2). Using gene synteny analysis, we identified a distinct isoform of the zebrafish IFNGR1...
Matthews R, Eauclaire S, Mugnier M, Lorent K, Cui S, Ross M, et al
. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Hepatology. 2011;53:905-14 pubmed publisher
Sawamiphak S, Kontarakis Z, Stainier D. Interferon gamma signaling positively regulates hematopoietic stem cell emergence. Dev Cell. 2014;31:640-53 pubmed publisher
..Here we show that the proinflammatory cytokine interferon-Î³ (IFN-Î³) and its receptor Crfb17 positively regulate HSC development in zebrafish...