Gene Symbol: ifih1
Description: interferon induced with helicase C domain 1
Alias: MDA5a, MDA5b, si:dkey-81j5.2, interferon-induced helicase C domain-containing protein 1, mda5, melanoma differentiation-associated protein 5a, melanoma differentiation-associated protein 5b
Species: zebrafish

Top Publications

  1. Biacchesi S, LeBerre M, Lamoureux A, Louise Y, Lauret E, Boudinot P, et al. Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses. J Virol. 2009;83:7815-27 pubmed publisher
    ..This report provides the first demonstration that teleost fish possess a functional RLR pathway in which MAVS may play a central role in the induction of the innate immune response...
  2. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  3. Chen W, Hu Y, Zou P, Ren S, Nie P, Chang M. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49:19-30 pubmed publisher
    ..cooperated with RIG-I in the accumulation of RIG-I transcript in a positive feedback loop; MAVS_tv2 synergized with MDA5 in the accumulation of MAVS_tv2 transcript...
  4. Estepa A, Coll J. Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS ONE. 2015;10:e0135483 pubmed publisher
    ..The implications of the so-called "trained immunity" for future research in this field are also discussed. ..
  5. Zou P, Chang M, Xue N, Liu X, Li J, Fu J, et al. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141:192-202 pubmed publisher
    ..In the present study, MDA5 and its spliced shorter forms, named as MDA5a and MDA5b, were identified in zebrafish...
  6. Varela M, Romero A, Dios S, van der Vaart M, Figueras A, Meijer A, et al. Cellular visualization of macrophage pyroptosis and interleukin-1? release in a viral hemorrhagic infection in zebrafish larvae. J Virol. 2014;88:12026-40 pubmed publisher
    ..The use of this animal model with other pathogens could improve the current knowledge on host-pathogen interactions and increase the potential for the discovery of new therapeutic targets against diverse viral diseases. ..
  7. Chen H, Liu W, Wu S, Chiou P, Li Y, Chen Y, et al. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015;43:427-35 pubmed publisher
    ..Taken together, our results indicate that RIG-I plays an essential role in zebrafish group II type I IFN induction and the inflammatory response to NNV infection. ..
  8. Gabor K, Charette J, Pietraszewski M, Wingfield D, Shim J, Millard P, et al. A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance. Dev Comp Immunol. 2015;51:298-304 pubmed publisher
    Melanoma Differentiation-Associated protein 5 (MDA5) is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family, which is a cytosolic pattern recognition receptor that detects viral nucleic acids...
  9. Liu J, Li J, Xiao J, Chen H, Lu L, Wang X, et al. The antiviral signaling mediated by black carp MDA5 is positively regulated by LGP2. Fish Shellfish Immunol. 2017;66:360-371 pubmed publisher
    Melanoma differentiation-associated gene 5 (MDA5) belongs to RIG-I like receptor (RLR) family, which detects cytosolic viral RNA component in immune response...

More Information


  1. Dios S, Romero A, Chamorro R, Figueras A, Novoa B. Effect of the temperature during antiviral immune response ontogeny in teleosts. Fish Shellfish Immunol. 2010;29:1019-27 pubmed publisher
    ..Thus, Mx seems to play an important role in viral immunity in larvae, when the adaptive immune response is not fully functional. ..
  2. Nie L, Zhang Y, Dong W, Xiang L, Shao J. Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity. Dev Comp Immunol. 2015;48:95-101 pubmed publisher
  3. Wang W, Asim M, Yi L, Hegazy A, Hu X, Zhou Y, et al. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates. Int J Mol Sci. 2015;16:6235-50 pubmed publisher
    ..the expressions of Retinoic acid-inducible gene I (RIG-I) and Melanoma differentiation-associated gene 5 (MDA5) were also all up-regulated significantly during the infection...
  4. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  5. Zou P, Chang M, Li Y, Xue N, Li J, Chen S, et al. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS. Fish Shellfish Immunol. 2016;55:173-85 pubmed publisher
    ..in zebrafish (Danio rerio), and its interaction with a receptor-interaction protein, RIPK2, and RLRs such as MDA5 and RIG-I, as well as the adaptor, MAVS was revealed in fish innate immunity...