id2a

Summary

Gene Symbol: id2a
Description: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a
Alias: cb321, id2, wu:fa04e03, DNA-binding protein inhibitor ID-2
Species: zebrafish

Top Publications

  1. pmc Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA
    Development 137:3763-74. 2010
  2. ncbi Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics
    Shang Wei Chong
    Laboratory of Fish Developmental Biology, Institute of Molecular and Cell Biology, National University of Singapore
    Dev Dyn 234:1055-63. 2005
  3. pmc Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712, USA
    Dev Biol 371:280-92. 2012
  4. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
  5. pmc Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
    Daniela Peukert
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Germany
    PLoS Biol 9:e1001218. 2011
  6. pmc Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina
    Jing Luo
    Department of Ophthalmology and Visual Sciences, University of Michigan, W, K, Kellogg Eye Center, 1000 Wall Street, Ann Arbor, MI 48105 0714, USA
    Neural Dev 7:33. 2012
  7. pmc Discovery and assessment of conserved Pax6 target genes and enhancers
    Pedro Coutinho
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 21:1349-59. 2011
  8. pmc Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein
    David M Wiley
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Cell Biol 13:686-92. 2011
  9. doi Differential expression and regulation of olig genes in zebrafish
    Natascia Tiso
    Department of Biology, University of Padova, I 35131 Padova, Italy
    J Comp Neurol 515:378-96. 2009
  10. pmc Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish
    Joanie C Neumann
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:13153-8. 2011

Scientific Experts

  • N Tiso
  • Pedro Coutinho
  • Rosa A Uribe
  • Jeffrey M Gross
  • Jing Luo
  • Ankita Das
  • Daniela Peukert
  • Joanie C Neumann
  • David M Wiley
  • Shang Wei Chong
  • Anda Alexandra Calinescu
  • Taejoon Kwon
  • Edward M Marcotte
  • Sarah Hayton
  • J Gage Crump
  • Peter F Hitchcock
  • James F Amatruda
  • Steffen Scholpp
  • Garvin L Chandler
  • Victoria L Bautch
  • Sabrina Weber
  • Vanessa A Damoulis
  • Jijun Hao
  • Suk Won Jin
  • Nicholas J Fustino
  • Dinesh Rakheja
  • Katherine Lillard
  • Charles C Hong
  • Leendert Looijenga
  • Jun Dae Kim
  • Linda Margraf
  • Andrew Lumsden
  • Vladimir Korzh
  • Yun Jin Jiang
  • Thi Thu Hang Nguyen
  • Lee Thean Chu

Detail Information

Publications10

  1. pmc Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA
    Development 137:3763-74. 2010
    ..Using loss-of-function and overexpression assays in zebrafish, we demonstrate that Id2a levels modulate retinoblast cell cycle kinetics and thereby influence neuron and glia formation in the retina...
  2. ncbi Zebrafish id2 developmental expression pattern contains evolutionary conserved and species-specific characteristics
    Shang Wei Chong
    Laboratory of Fish Developmental Biology, Institute of Molecular and Cell Biology, National University of Singapore
    Dev Dyn 234:1055-63. 2005
    ..We isolated zebrafish id2, and its expression during development was characterized...
  3. pmc Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis
    Rosa A Uribe
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Austin, TX 78712, USA
    Dev Biol 371:280-92. 2012
    ..We recently uncovered a cell non-autonomous role for the intrinsic HLH factor, Id2a, in regulating retinoblast proliferation and differentiation, with Id2a-deficient retinae containing an abundance ..
  4. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
    ..We also show that Id2a restricts Twist1 activity to the ectomesenchyme lineage, with Bmp activity preferentially inducing id2a expression ..
  5. pmc Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
    Daniela Peukert
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Germany
    PLoS Biol 9:e1001218. 2011
    ..We therefore suggest that after initial neural tube patterning, neurogenesis within a brain compartment influences the integrity of the neuronal progenitor pool and border formation of a neuromeric compartment...
  6. pmc Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina
    Jing Luo
    Department of Ophthalmology and Visual Sciences, University of Michigan, W, K, Kellogg Eye Center, 1000 Wall Street, Ann Arbor, MI 48105 0714, USA
    Neural Dev 7:33. 2012
    ..In this study, loss-of-function and conditional overexpression were used to investigate the function of Mdka in the retina of the embryonic zebrafish...
  7. pmc Discovery and assessment of conserved Pax6 target genes and enhancers
    Pedro Coutinho
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genome Res 21:1349-59. 2011
    ..We have identified several novel direct targets, including some putative disease genes, among them Foxp2; these will allow further dissection of Pax6 function in development and disease...
  8. pmc Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein
    David M Wiley
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Cell Biol 13:686-92. 2011
    ....
  9. doi Differential expression and regulation of olig genes in zebrafish
    Natascia Tiso
    Department of Biology, University of Padova, I 35131 Padova, Italy
    J Comp Neurol 515:378-96. 2009
    ..Our findings suggest a role for olig genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation...
  10. pmc Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish
    Joanie C Neumann
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:13153-8. 2011
    ..These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation, and highlight the importance of the BMP pathway in human GCTs...