Gene Symbol: htr1ab
Description: 5-hydroxytryptamine (serotonin) receptor 1A b
Alias: 5-hydroxytryptamine (serotonin) receptor 1A b, 5-hydroxytryptamine 1 ab receptor
Species: zebrafish

Top Publications

  1. Manuel R, Zethof J, Flik G, van den Bos R. Providing a food reward reduces inhibitory avoidance learning in zebrafish. Behav Processes. 2015;120:69-72 pubmed publisher
    ..These results suggest that providing rewards at fixed intervals alters fear avoidance behaviour, albeit modestly, in zebrafish. We discuss the data in the context of similar underlying brain structures in mammals and fish. ..
  2. Lim S, Wang Y, Yu X, Huang Y, Featherstone M, Sampath K. A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases. Genome Biol. 2013;14:R69 pubmed publisher
    ..Our strategy of heritable chromosomal editing can be used for disease modeling, analyzing gene clusters, regulatory regions, and determining the functions of non-coding RNAs in genomes. ..
  3. Wang X, Yang L, Wang Q, Guo Y, Li N, Ma M, et al. The neurotoxicity of DE-71: effects on neural development and impairment of serotonergic signaling in zebrafish larvae. J Appl Toxicol. 2016;36:1605-1613 pubmed publisher
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  4. Gorissen M, Manuel R, Pelgrim T, Mes W, de Wolf M, Zethof J, et al. Differences in inhibitory avoidance, cortisol and brain gene expression in TL and AB zebrafish. Genes Brain Behav. 2015;14:428-38 pubmed publisher
    ..We conclude that AB fish show higher cortisol levels and no inhibitory avoidance than TL fish. The differential learning responses of these Danio strains may unmask genetically defined risks for stress-related disorders. ..
  5. Sourbron J, Schneider H, Kecskés A, Liu Y, Buening E, Lagae L, et al. Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. ACS Chem Neurosci. 2016;7:588-98 pubmed publisher
    ..Modulating certain serotonergic receptors was shown to effectively reduce seizures. Our findings therefore open new avenues for the development of future novel DS therapeutics. ..
  6. Norton W, Folchert A, Bally Cuif L. Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain. J Comp Neurol. 2008;511:521-42 pubmed publisher
    ..genes slc6a4a and slc6a4b, which identify 5-HT-producing neurons and three novel 5-HT receptors, htr1aa, htr1ab, and htr1bd...
  7. Manuel R, Gorissen M, Roca C, Zethof J, van de Vis H, Flik G, et al. Inhibitory avoidance learning in zebrafish (Danio rerio): effects of shock intensity and unraveling differences in task performance. Zebrafish. 2014;11:341-52 pubmed publisher
    ..These findings serve as starting point for further unraveling differences in brain-behavior relationships underlying (fear avoidance) learning and memory in zebrafish. ..
  8. Manuel R, Gorissen M, Stokkermans M, Zethof J, Ebbesson L, van de Vis H, et al. The effects of environmental enrichment and age-related differences on inhibitory avoidance in zebrafish (Danio rerio Hamilton). Zebrafish. 2015;12:152-65 pubmed publisher
    ..Overall, our data show strong differences in inhibitory avoidance behavior between zebrafish of different ages and a clear reduction in avoidance behavior following housing under environmental enrichment. ..
  9. Prasad P, Ogawa S, Parhar I. Serotonin reuptake inhibitor citalopram inhibits GnRH synthesis and spermatogenesis in the male zebrafish. Biol Reprod. 2015;93:102 pubmed publisher
    ..These results show morphological and functional associations between the 5-HT and the hypophysiotropic GnHR3 system, which involve SSRI-induced reproductive failures. ..

More Information


  1. Mechaly A, Richardson E, Rinkwitz S. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. Gen Comp Endocrinol. 2017;246:233-240 pubmed publisher
    ..This is in line with a previously demonstrated anorexigenic function of serotonin. Our results suggest that obesity-associated ETV5 has a food intake stimulating function and that this function is modulated through serotonin. ..
  2. Wu Q, Yan W, Cheng H, Liu C, Hung T, Guo X, et al. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environ Pollut. 2017;231:471-478 pubmed publisher
    ..was remarkably decreased in MCLR parental exposure groups, while the expression levels of manf, bdnf, ache, htr1ab, htr1b, htr2a, htr1aa, htr5a, DAT, TH1 and TH2 genes coincided with the decreased content of neurotransmitters (..
  3. Herculano A, Maximino C. Serotonergic modulation of zebrafish behavior: towards a paradox. Prog Neuropsychopharmacol Biol Psychiatry. 2014;55:50-66 pubmed publisher
  4. Manuel R, Gorissen M, Zethof J, Ebbesson L, van de Vis H, Flik G, et al. Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen long-fin zebrafish: stronger effects in the resting phase than in the active phase. J Exp Biol. 2014;217:3919-28 pubmed publisher
    ..Our data warrant further studies on the effect of UCS on stress axis-related genes, especially grβ; in mammals this receptor has been implicated in glucocorticoid resistance and depression. ..
  5. Pei S, Liu L, Zhong Z, Wang H, Lin S, Shang J. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Sci Rep. 2016;6:33822 pubmed publisher
    ..These findings support a possible long-term risk of serotonin pathway alteration, possibly resulting from the "placental drug transfer". ..
  6. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS ONE. 2012;7:e52549 pubmed publisher
    ..In conclusion, we have developed an assay that uses zebrafish, which can be applied to high-throughput screening and target gene discovery for appetite suppressants and enhancers. ..
  7. Barreiro Iglesias A, Mysiak K, Scott A, Reimer M, Yang Y, Becker C, et al. Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell Rep. 2015;13:924-32 pubmed publisher
    ..Regeneration of spinal-intrinsic serotonergic interneurons was unaltered by these manipulations. Hence, serotonin selectively promotes the development and adult regeneration of motor neurons in zebrafish. ..