Gene Symbol: hspd1
Description: heat shock 60 protein 1
Alias: cb863, cpn60, fa04a05, fb22d10, fi27b05, id:ibd2197, sb:cb144, wu:fa04a05, wu:fb22d10, wu:fi04a12, wu:fi27b05, 60 kDa heat shock protein, mitochondrial, heat shock 60kD protein 1 (chaperonin), hsp60, nbl, no blastema
Species: zebrafish
Products:     hspd1

Top Publications

  1. Makino S, Whitehead G, Lien C, Kim S, Jhawar P, Kono A, et al. Heat-shock protein 60 is required for blastema formation and maintenance during regeneration. Proc Natl Acad Sci U S A. 2005;102:14599-604 pubmed
    ..We used a chemical mutagenesis screen to identify no blastema (nbl), a zebrafish mutant with an early fin regeneration defect...
  2. Qin Z, Barthel L, Raymond P. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009;106:9310-5 pubmed publisher
    ..from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated...
  3. Bosworth C, Chou C, Cole R, Rees B. Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. Proteomics. 2005;5:1362-71 pubmed
    ..The difference between protein and mRNA expression illustrates the need to integrate both measures for a more complete understanding of gene expression in fish during hypoxic exposure. ..
  4. Sifuentes C, Kim J, Swaroop A, Raymond P. Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish. Invest Ophthalmol Vis Sci. 2016;57:5148-5160 pubmed publisher
    ..These regulatory mechanisms are relatively unexplored as potential mediators of stem cell properties likely to be important in Müller glial cells for successful retinal regeneration. ..
  5. Liu L, Xu Y, Xu L, Wang J, Wu W, Xu L, et al. Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:183-9 pubmed
    ..These data may help us understand the functions and the molecular mechanisms of these proteins in zebrafish embryos' response to CPF exposure. ..
  6. Robles V, Marti M, Izpisua Belmonte J. Study of pluripotency markers in zebrafish embryos and transient embryonic stem cell cultures. Zebrafish. 2011;8:57-63 pubmed publisher
    ..We consider this study a step forward in the knowledge of zebrafish pluripotency markers and, therefore, an important tool for the monitoring of zebrafish embryonic cell cultures. ..
  7. Martin C, Tsang C, Beiko R, Krone P. Expression and genomic organization of the zebrafish chaperonin gene complex. Genome. 2002;45:804-11 pubmed
    ..In the present study, we have isolated a cDNA encoding chaperonin 60 (cpn60) from zebrafish, and have shown that it is similarly expressed uniformly and ubiquitously throughout early ..
  8. Craig P, Hogstrand C, Wood C, McClelland G. Gene expression endpoints following chronic waterborne copper exposure in a genomic model organism, the zebrafish, Danio rerio. Physiol Genomics. 2009;40:23-33 pubmed publisher
    ..5% contained only a consensus MRE. We conclude that the indirect effects of Cu exposure regulate gene expression to a much greater degree than the direct effects. ..
  9. Christen B, Robles V, Raya M, Paramonov I, Izpisua Belmonte J. Regeneration and reprogramming compared. BMC Biol. 2010;8:5 pubmed publisher
    ..We therefore propose a link between partially reprogrammed induced pluripotent stem cells and the half way state of blastema cells and suggest that a common mechanism might be regulating these two processes. ..

More Information


  1. Ramachandran R, Fausett B, Goldman D. Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol. 2010;12:1101-7 pubmed publisher
    ..Furthermore, we demonstrate that let-7 represses expression of regeneration-associated genes such as, ascl1a, hspd1, lin-28, oct4, pax6b and c-myc...
  2. De Felice B, Copia L, Guida M. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. Mol Biol Rep. 2012;39:2119-28 pubmed publisher
    ..Our results, for the first time, provide an insight into some of the varied and novel molecular networks following zebrafish exposure to diclofenac polluted waters. ..
  3. Ponnudurai R, Basak T, Ahmad S, Bhardwaj G, Chauhan R, Singh R, et al. Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A. J Proteomics. 2012;75:1004-17 pubmed publisher
    ..Our findings demonstrate that CsA administration during early morphogenesis in zebrafish modulates the expression of some proteins which are known to be involved in important physiological processes. ..
  4. Xu Q, Qin Y. Molecular cloning of heat shock protein 60 (PtHSP60) from Portunus trituberculatus and its expression response to salinity stress. Cell Stress Chaperones. 2012;17:589-601 pubmed publisher
    Heat shock protein 60 (HSP60) is a highly conserved and multi-functional molecular chaperone that plays an essential role in both cellular metabolism and stress response...
  5. Yabu T, Shimuzu A, Yamashita M. A novel mitochondrial sphingomyelinase in zebrafish cells. J Biol Chem. 2009;284:20349-63 pubmed publisher
    ..These observations indicate that SMase catalyzes the hydrolysis of sphingomyelin and generates ceramide in mitochondria in fish cells. ..
  6. Hawkins T, Haramis A, Etard C, Prodromou C, Vaughan C, Ashworth R, et al. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 2008;135:1147-56 pubmed publisher
    ..Our studies reveal a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in sarcomere assembly. ..
  7. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..
  8. Li J, Hou G, Kong X, Li C, Zeng J, Li H, et al. The fate of recent duplicated genes following a fourth-round whole genome duplication in a tetraploid fish, common carp (Cyprinus carpio). Sci Rep. 2015;5:8199 pubmed publisher
    ..Our analysis revealed slow gene loss but rapid and intense expression and function differentiation after WGD. ..